Shenzhen Haibin Pharmaceutical Co., Ltd.

Preliminary exploration of the changes in sputum PA in patients with acute exacerbation of bronchiectasis and PA infection treated with tobramycin nebulized inhalation on the basis of systemic anti-infection.

Primary objective: To evaluate the pharmacokinetic characteristics of JKN2301 dry suspension (Formulation 1) and TG-1000 capsules (Formulation 2) after single administration in healthy Chinese adult male participants under fasting conditions. Secondary objective: To evaluate the safety of single oral doses of JKN2301 dry suspension (Formulation 1) and TG-1000 capsules (Formulation 2) in healthy Chinese adult male participants.

To evaluate the safety and tolerability of a single oral administration of JKN2306 tablets in healthy subjects. Secondary objectives: To evaluate the pharmacokinetic (PK) characteristics of a single oral administration of JKN2306 tablets in healthy subjects; to evaluate the effect of a high-fat diet on the PK characteristics of a single oral administration of JKN2306 tablets in healthy subjects. Exploratory objectives: To explore the C-QTc relationship after a single oral administration of JKN2306 tablets in healthy subjects; to explore the metabolites in the blood after a single oral administration of JKN2306 tablets in healthy subjects.