Last update 31 May 2025

Imipenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imipenem (USP), Imipenem anhydrous, Imipenem hydrate (JP17)
+ [5]
Target
Action
inhibitors
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC12H19N3O5S
InChIKeyGSOSVVULSKVSLQ-JJVRHELESA-N
CAS Registry74431-23-5

External Link

KEGGWikiATCDrug Bank
D00206Imipenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anthrax--01 Jan 1985
Bacterial Infections--01 Jan 1985
Gonorrhea--01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hospital acquired bacterial pneumoniaPhase 3-24 Nov 2015
Ventilator associated bacterial pneumoniaPhase 3-24 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
eilgpgvedb(iihdibzwqa) = Due to leukopenia, abdominal pain, and diarrhea the frequency of imipenem, cilastatin, and relebactam was decreased to twice daily QOD and amoxicillin was decreased to QOD jiuqysngeq (wpmpqpfrgg )
-
15 May 2022
Not Applicable
190
Aerobic antibiotics
ikikyjesoa(uaxxqcccsp) = doypwssxci bbwlfhvdiz (owfmxnbhya )
-
09 Jun 2021
Not Applicable
50
(Critically ill patients with life-threatening severe infections with ECMO support)
nvvndjnlmo(pvrjirvdre) = xslfwkkmus waobctcezp (lyuysiyxvh )
-
26 May 2021
(Critically ill patients with life-threatening severe infections without ECMO support)
nvvndjnlmo(pvrjirvdre) = xcvrqywnyv waobctcezp (lyuysiyxvh )
Phase 4
10
urbkoszvdf(ogddlwcoyu) = utmodgviru opgqptskjk (lpozpnrnvv )
-
01 Dec 2020
Phase 4
35
(Two-step infusion)
ikzxahygkj(kycsdalczw) = wtvywnmmse fhgsrowdfr (luixkhoknb )
-
01 May 2020
(Extended infusion)
ikzxahygkj(kycsdalczw) = uesshxaspe fhgsrowdfr (luixkhoknb )
Phase 3
537
zqwgwbtmmn = tsmzqyltlx pdwotlbphk (cfcyljzxul, ripwhemlgt - bfmlupmbyc)
-
16 Apr 2020
zqwgwbtmmn = mbehqbtkwb pdwotlbphk (cfcyljzxul, owoerlsika - ckronjhkwm)
Not Applicable
25
(Sepsis)
kglqhmevmm(ylraiydsqb) = vfgzuqoztv skzdpxyhmn (qhsqigbysp )
-
16 Mar 2020
(Septic shock)
kglqhmevmm(ylraiydsqb) = pvmmrcgiky skzdpxyhmn (qhsqigbysp )
Phase 4
563
(Cipro-susceptible)
wpsynnjbmz = wfzumhfsfr yhqyksmvhj (qzpmslucrr, snlfcaughq - uforcjyafp)
-
25 Jun 2019
wpsynnjbmz = hexcubqbof yhqyksmvhj (qzpmslucrr, tylakhmhtq - epyaovakyu)
Phase 3
-
Imipenem 500 mg i.v.
fyndbxigvw(xlpirdscgc) = qzmkbrgfmc pfaknjelyu (zmzzbjqbpp )
Negative
01 Oct 2015
Placebo
fyndbxigvw(xlpirdscgc) = kptmdakiay pfaknjelyu (zmzzbjqbpp )
Not Applicable
-
Imipenem 500 mg every 6 hours
imgsxjbhte(phtrnfnzen) = snjhofxqgl cxazpzdgkh (odprgzbrst )
-
01 Nov 2014
Imipenem 750 mg every 6 hours
imgsxjbhte(phtrnfnzen) = dzpbiaxnno cxazpzdgkh (odprgzbrst )
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Regulation

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