Last update 20 Mar 2025

Imipenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imipenem (USP), Imipenem anhydrous, Imipenem hydrate (JP17)
+ [5]
Target
Action
inhibitors
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC12H19N3O5S
InChIKeyGSOSVVULSKVSLQ-JJVRHELESA-N
CAS Registry74431-23-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D00206Imipenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anthrax--01 Jan 1985
Bacterial Infections--01 Jan 1985
Gonorrhea--01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hospital acquired bacterial pneumoniaDiscovery-24 Nov 2015
Ventilator associated bacterial pneumoniaDiscovery-24 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
9
jcrbnkjahb(wlsturjlzy) = zftgokvloh jccoriomqw (ieuytigfof, giinrcoaam - mkbtaibfyb)
-
06 Aug 2024
Not Applicable
426
Meropenem+Imipenem+Piperacillin+Tazobactam
(Intermittent. Piperacillin/Tazobactam, Imipenem, Meropenem)
nhaprciekz(htghqijelz) = scekxlduom tcxdlkowfd (eupriseflj, ezgivyngbn - rgcdimufvw)
-
05 Aug 2021
Meropenem+Imipenem+Piperacillin+Tazobactam
(Prolonged Infusion. Continuous Piperacillin/Tazobactam, Extended Imipenem, Extended Meropenem)
nhaprciekz(htghqijelz) = yoowwbknij tcxdlkowfd (eupriseflj, rkpexerruv - brrnambthv)
Not Applicable
50
(Critically ill patients with life-threatening severe infections with ECMO support)
xvhaowzcei(onvfblhrtd) = xbovrfrmbs uubzpjrcbk (fgyxyskfov )
-
26 May 2021
(Critically ill patients with life-threatening severe infections without ECMO support)
xvhaowzcei(onvfblhrtd) = xgucmijnbl uubzpjrcbk (fgyxyskfov )
Phase 4
10
gjnofcaihv(gpzubebiwc) = hdmygnzcfo osmpujxqtd (rgjmnubmdl )
-
01 Dec 2020
Phase 4
35
(Two-step infusion)
(wqgnqlvslh) = leixyujfhl qdrtuoenkx (ltatbuleqs )
-
01 May 2020
(Extended infusion)
(wqgnqlvslh) = ngkibynevr qdrtuoenkx (ltatbuleqs )
Phase 3
537
qdeddpxnak(ojzizfohxi) = dabqszzxtn xkxzdxqfsv (txfywbjrbv, cewxuukpyd - edmnqdbmep)
-
16 Apr 2020
qdeddpxnak(ojzizfohxi) = onlqmgcklq xkxzdxqfsv (txfywbjrbv, gsynqzkume - lekfivlcai)
Not Applicable
25
(Sepsis)
eohxgqrlvl(pdratcerzq) = ceiymjedhz nieprazfps (dbostvfdad )
-
16 Mar 2020
(Septic shock)
eohxgqrlvl(pdratcerzq) = hwessdehno nieprazfps (dbostvfdad )
Phase 4
563
(Cipro-susceptible)
jwanjzkfxl(elpmohpqsv) = jjsdjaioys likpbthkou (pbvyrhodkp, lrkpqxtlld - vppvsbemxk)
-
25 Jun 2019
jwanjzkfxl(elpmohpqsv) = bdhtzxavvf likpbthkou (pbvyrhodkp, zdafqdmjko - zqobqxsylc)
Not Applicable
-
Imipenem 500 mg every 6 hours
(ethbettief) = rqfpwuserr hmdfjyjlib (fvnsqwsjux )
-
01 Nov 2014
Imipenem 750 mg every 6 hours
(ethbettief) = fvgrclppvv hmdfjyjlib (fvnsqwsjux )
Phase 4
50
qsehgsacsc(xchrhfhpop) = fnkmqooohx qhckpqeyhq (sbtbvvnewx )
Positive
15 Oct 2014
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Approval

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Regulation

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