[Translation] A Phase I/II, first-in-human, open-label, dose-escalation and indication expansion study evaluating the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary efficacy of BNT3212 as monotherapy or in combination with BNT327 in adult patients with advanced solid tumors
在剂量递增(A部分和C部分):确定每个部分的最大耐受剂量(MTD),并评估 BNT3212 在接受 BNT3212 单药治疗和 BNT3212 + BNT327 联合治疗的晚期实体瘤成人患者中的整体安全性和耐受性。扩展队列(B部分和 D部分):评估 BNT3212 在特定适应症队列中单药治疗及联合 BNT327 治疗后的安全性。
[Translation] In the dose escalation cohort (Parts A and C), the maximum tolerated dose (MTD) in each cohort will be determined, and the overall safety and tolerability of BNT3212 will be evaluated in adult patients with advanced solid tumors receiving BNT3212 monotherapy and the combination of BNT3212 and BNT327. In the expansion cohort (Parts B and D), the safety of BNT3212 as a monotherapy and in combination with BNT327 will be evaluated in the indication-specific cohorts.