Delving into the Latest Updates on Merrell Dow Pharmaceuticals, Inc. with Synapse

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Small molecule drug

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Top 5 Drug Type	Count

Small molecule drug	2

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DAT x NET	1

In anesthetized dogs, MDL 17043 (I) [77671-31-9] (0.1, 0.3, or 1 mg/kg, i.v.) produced dose-related increases in cardiac contractility, heart rate, and coronary artery blood flow, and dose-related decreases in mean arterial pressure.These changes were not accompanied by significant changes in myocardial O consumption, although slight transient increases in O consumption coincided with the peak increase in cardiac contractility and heart rate produced by I.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

β2-Adrenergic agonist effects of medroxalol and labetalol on rat and mouse uterine muscle

Q3 · MEDICINE

Article

Author: Woodward, James K ; Cheng, Hsien C

In KCl-contracted uterine muscle strips isolated from rats and mice, the concentration-relaxation response curves produced by the adrenoceptor blockers medroxalol (I) [56290-94-9] and labetalol (II) [36894-69-6] appeared to be biphasic.An initial gradual relaxation phase occurred at 10^-8-10^-5M and a subsequent steep relaxation phase at 10^-5-10^-4M for both compoundsThe gradual relaxation phase was antagonized by propranolol, whereas the steep relaxation phase was not.Thus, I and II have β₂-adrenoceptor agonist activity which relaxes uterine muscle, and an addnl. relaxant activity which is unrelated to β-adrenoceptor activation.

01 Oct 1990·Journal of Quality Technology

Statistical Methodology in the Pharmaceutical Sciences

Author: Ruberg, Stephen J.

(1990). Statistical Methodology in the Pharmaceutical Sciences. Journal of Quality Technology: Vol. 22, No. 4, pp. 331-332.

100 Deals associated with Merrell Dow Pharmaceuticals, Inc.

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100 Translational Medicine associated with Merrell Dow Pharmaceuticals, Inc.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

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1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Lactulose	Constipation More	Approved
Cilobamine ( DAT x NET )	Depressive Disorder More	Preclinical
Terfenadine ( H1 receptor )	Rhinitis, Allergic, Seasonal More	Withdrawn