Delving into the Latest Updates on Merrell Dow Pharmaceuticals, Inc. with Synapse

Overview

Tags

Other Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

No Data

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

DAT x NET	1

In anesthetized dogs, MDL 17043 (I) [77671-31-9] (0.1, 0.3, or 1 mg/kg, i.v.) produced dose-related increases in cardiac contractility, heart rate, and coronary artery blood flow, and dose-related decreases in mean arterial pressure.These changes were not accompanied by significant changes in myocardial O consumption, although slight transient increases in O consumption coincided with the peak increase in cardiac contractility and heart rate produced by I.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

β2-Adrenergic agonist effects of medroxalol and labetalol on rat and mouse uterine muscle

Q3 · MEDICINE

Article

Author: Woodward, James K ; Cheng, Hsien C

In KCl-contracted uterine muscle strips isolated from rats and mice, the concentration-relaxation response curves produced by the adrenoceptor blockers medroxalol (I) [56290-94-9] and labetalol (II) [36894-69-6] appeared to be biphasic.An initial gradual relaxation phase occurred at 10^-8-10^-5M and a subsequent steep relaxation phase at 10^-5-10^-4M for both compoundsThe gradual relaxation phase was antagonized by propranolol, whereas the steep relaxation phase was not.Thus, I and II have β₂-adrenoceptor agonist activity which relaxes uterine muscle, and an addnl. relaxant activity which is unrelated to β-adrenoceptor activation.

01 Oct 1990·Journal of Quality Technology

Statistical Methodology in the Pharmaceutical Sciences

Author: Ruberg, Stephen J.

(1990). Statistical Methodology in the Pharmaceutical Sciences. Journal of Quality Technology: Vol. 22, No. 4, pp. 331-332.

100 Deals associated with Merrell Dow Pharmaceuticals, Inc.

Login to view more data

100 Translational Medicine associated with Merrell Dow Pharmaceuticals, Inc.

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 14 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Approved

Other

1

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Lactulose	Constipation More	Approved
Cilobamine ( DAT x NET )	Depressive Disorder More	Preclinical
Terfenadine ( H1 receptor )	Rhinitis, Allergic, Seasonal More	Withdrawn