Creative Medical Technology Holdings, Inc.

Feb. 14, 2025 -- Creative Medical Technology Holdings, Inc. ("Creative Medical Technology" or the "Company") (NASDAQ: CELZ), a pioneering biotechnology firm specializing in regenerative medicine solutions for immunotherapy, endocrinology, urology, gynecology, and orthopedics, today announced compelling mid-term follow-up data from its StemSpine® pilot study utilizing its AlloStem™ cells for the treatment of chronic lower back pain. The pilot study demonstrated a substantial reduction in opioid dependency and significant improvements in pain levels and functional mobility. Notably, over 90% of patients reported no opioid use for pain management three years post-procedure, with an 80% persistent reduction in pain scores and a greater than 60% improvement in Oswestry Disability Index scores. Only one patient required reintervention at the three-year follow-up mark, and no serious adverse events were reported, reinforcing the favorable safety profile of the StemSpine® procedure. StemSpine® is a proprietary, patented, non-surgical, ultrasound-guided procedure that leverages AlloStem™, an "off-the-shelf" allogenic (donor-derived) cell therapy developed by the Company. The StemSpine® patent encompasses the use of both autologous (patient-derived) and allogenic cells, broadening its clinical utility. "Opioid dependency remains a pressing concern for individuals suffering from chronic lower back pain," said Timothy Warbington, President and CEO of Creative Medical Technology Holdings. "These results underscore the safety and clinical efficacy of AlloStem™ in the StemSpine® procedure by promoting repair, remodeling, and improved vascularization in the affected areas. This promising data supports our vision of providing innovative, non-surgical solutions for millions of Americans struggling with chronic lower back pain.” The StemSpine pilot study data is independent of the Company’s ongoing FDA-cleared Phase 1/2 ADAPT clinical trial of CELZ-201-DDT for chronic lower back pain; however, these compelling findings continue to drive strong enrollment in the prospective, randomized, double-blind, dose-escalation ADAPT study, further reinforcing StemSpine® as a groundbreaking advancement in regenerative medicine. Study Details | Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain | ClinicalTrials.gov Creative Medical Technology Holdings, Inc. is a biotechnology company dedicated to the advancement of identifying and translating novel biological therapeutics in the fields of immunotherapy, endocrinology, urology, gynecology, and orthopedics and is traded on NASDAQ under the ticker symbol CELZ. For further information about the Company, please visit www.creativemedicaltechnology.com. The content above comes from the network. if any infringement, please contact us to modify.

Feb. 11, 2025 -- Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ), a clinical-stage biotechnology company advancing regenerative medicine solutions, today announced promising one-year follow-up data from the AlloStem ™ (CELZ-201) Type 2 Diabetes pilot study for late-stage patients. CELZ-201 is an off the shelf, ready-to-use universal and proprietary allogenic (donor) cell line developed by the Company. Results demonstrate that CELZ-201 achieved an 80% overall efficacy rate in reducing insulin dependency and stabilizing hemoglobin A1c levels, with no serious adverse effects reported. The study, which included 20 patients—10 receiving CELZ-201 and 10 undergoing optimized medical therapy—validated the safety and efficacy of CELZ-201 through the same infusion procedure used in the Company’s U.S. FDA-cleared Type 1 Diabetes clinical trial, which is currently underway. The absence of safety concerns further supports the potential of CELZ-201 as a breakthrough treatment for late-stage Type 2 Diabetes. Given these compelling results, Creative Medical Technology plans to advance the development of AlloStem (CELZ-201) for the treatment of late-stage Type 2 Diabetes and explore other potential applications of this therapy to expand the Company’s pipeline. "The positive one-year data from the study represents a significant milestone in our mission to revolutionize diabetes treatment and help a wide variety of patients who potentially may not benefit from autologous therapies," said Timothy Warbington, President and CEO of Creative Medical Technology. "With a diversified portfolio that includes CELZ-201 for early-stage Type 1 Diabetes, CELZ-101 for brittle Type 1 Diabetes, and CELZ-201 for late-stage Type 2 Diabetes, we are committed to delivering innovative solutions that transform patient care." Type 2 diabetes affects approximately 90-95% of the 38 million Americans diagnosed with diabetes. While initially managed through diet, exercise, and oral medications, many patients eventually require insulin therapy as the disease progresses. Diabetes remains the eighth leading cause of death in the U.S., with over 96 million adults classified as prediabetic—more than 80% of whom are unaware of their condition. Creative Medical Technology Holdings, Inc. is a clinical-stage biotechnology company dedicated to developing groundbreaking regenerative cell therapies. The company’s pipeline targets a range of conditions, with a focus on endocrinology, immunotherapy, orthopedic and neurological diseases. The content above comes from the network. if any infringement, please contact us to modify.

Feb. 05, 2025 -- Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) (“Creative Medical”), a clinical-stage biotechnology company advancing regenerative medicine solutions, today announced an expanded agreement with Greenstone Biosciences Inc. (“Greenstone”) to leverage Artificial Intelligence (AI) in further developing its human induced pluripotent stem cell (iPSC) platform for diabetes treatment.This strategic collaboration extends the progress made on Creative Medical’s proprietary hypoimmune iPSC technology, including its iPSC-derived pancreatic islet cells. These innovative cell lines, developed from Good Manufacturing Practice (GMP) grade human perinatal cells, are currently being used in clinical trials. By integrating AI-driven drug discovery, the partnership aims to identify small molecules that enhance insulin secretion, further refining the therapeutic potential of Creative Medical’s hypoimmunogenic iPSC-derived pancreatic islet cells. Additionally, the program will implement multi-gene editing to develop next generation hypoimmune iPSC lines with enhanced stealth, survival, and differentiation capabilities. These advancements will not only optimize pancreatic islet cell function but also expand the platform’s applications to other regenerative therapies, addressing critical unmet medical needs. One of the most pressing challenges in stem cell-based therapies is the requirement for immunosuppression, which can lead to severe side effects, including mortality. By refining hypoimmune iPSC lines through AI-guided development, Creative Medical is actively working to overcome these barriers, paving the way for safer and more effective cell-based treatments for diabetes and other chronic conditions. “Creative Medical is at the forefront of regenerative medicine, and our extended partnership with Greenstone Biosciences marks a significant milestone in our mission to develop transformative therapies,” said Timothy Warbington, President and CEO of Creative Medical. “Dr. Wu and his team at Greenstone have been instrumental in validating and advancing our proprietary iPSC platform. By incorporating AI-driven methodologies, we estimate that this program will reduce R&D time by approximately 50% compared to other methods and produce millions of dollars in cost savings. We are poised to accelerate innovation, enhance therapeutic efficacy, and position ourselves as a leader in the evolving landscape of personalized medicine.” The next phase of development focuses on multi-gene edited hypoimmune iPSCs—cells engineered with precise modifications to evade immune detection, improve survival, and optimize therapeutic potential. These cutting-edge advancements offer the potential to eliminate the need for immunosuppression, significantly improving patient outcomes in cell-based regenerative therapies. As Creative Medical continues to push the boundaries of regenerative medicine, this collaboration reinforces its commitment to leveraging AI and genetic engineering to address some of the most pressing challenges in modern healthcare. Creative Medical Technology Holdings, Inc. is a clinical-stage biotechnology company dedicated to developing groundbreaking regenerative therapies using stem cell and immune modulation technologies. The company’s pipeline targets a range of conditions, with a focus on diabetes, autoimmune disorders, orthopedic and neurological diseases. For more information, visit www.creativemedicaltechnology.com. The content above comes from the network. if any infringement, please contact us to modify.