Delving into the Latest Updates on Chengdu University with Synapse

Overview

Tags

Urogenital Diseases

Neoplasms

Respiratory Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	2
Neoplasms	2

Top 5 Drug Type	Count

Small molecule drug	5

Top 5 Target	Count

PBPs(Bacterial penicillin-binding protein)	2
PI3Ks x PI3Kα	1
RAD52(RAD52 homolog, DNA repair protein)	1
P2X7 receptor(P2X purinoceptor 7)	1

进行本品的药代试验，测定主要成分经时血药和尿药浓度，估算其主要药代参数，了解本品在健康人体内的ADME规律，与愈酚伪麻口服溶液进行药代对比试验，为制定本品II期临床试验方案提供依据，为临床用药的给药剂量依据。

[Translation]

Conduct pharmacokinetic tests on this product, determine the time-dependent blood and urine concentrations of the main ingredients, estimate its main pharmacokinetic parameters, understand the ADME laws of this product in healthy humans, and conduct pharmacokinetic comparison tests with guaiac-pseudoephedrine oral solution to provide a basis for formulating the Phase II clinical trial plan for this product and provide a basis for the dosage of clinical medication.

Start Date22 Jun 2013

Sponsor / Collaborator

Shenzhen Zhijun Pharmaceutical Trade Co., Ltd.

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100 Clinical Results associated with Chengdu University

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0 Patents (Medical) associated with Chengdu University

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6,764

Literatures (Medical) associated with Chengdu University

31 Dec 2025·International Journal of Food Properties

Rheological Properties of Dysphagia Food Purees Prepared according to IDDSI Framework

Author: Qiu, Guoyuan ; Zhao, Yihan ; Xue, Yu ; Wang, Yan ; Hu, Wen ; Lyu, Yishu ; Yan, Jiuming ; Jiang, Xile ; Zhou, Linhua ; Wan, Zheng ; Liu, Xinying ; Shi, Xiaodong

The increasing prevalence of dysphagia in aging populations poses a significant risk of malnutrition due to compromised ingestion abilities.This is particularly a problem in non-tube-fed patients.This study addresses the urgent need for safe, palatable, and nutritionally adequate food options by developing a range of food purees made of vegetables, meats, and rice flour.The food purees were produced using high-speed blending techniques and their rheol. and textural properties were evaluated to ensure swallowing safety.The results demonstrated that these food purees can comply with the textural requirements of the International Dysphagia Diet Standardisation Initiative Level 4 and showed gel-like behaviors.The viscosity values of vegetable-meat purees and vegetable-meat-rice purees at shear rates of 50 s^-1 were from 0.62 to 1.77 Pa·s, 2.48 to 3.63 Pa·s, resp.Their hardness values ranged from 39.32 to 88.21 g.All the viscosity values fall within the reported safe range.These food purees may be easy to swallow.This research offers a practical and economical solution for enhancing the dietary intake and overall quality of life for people with dysphagia in clin. and home settings and contributes valuable quant. data to the field.

31 Dec 2025·Virulence

Multifaceted quorum-sensing inhibiting activity of 3-(Benzo[d][1,3]dioxol-4-yl)oxazolidin-2-one mitigates Pseudomonas aeruginosa virulence

Article

Author: Ma, Wenbo ; Zhao, Kelei ; Wu, Yi ; Ran, Qiman ; Chu, Yiwen ; Wen, Fulong ; Gou, Shiyi

As antibiotic resistance escalates into a global health crisis, novel therapeutic approaches against infectious diseases are in urgent need. Pseudomonas aeruginosa, an adaptable opportunistic pathogen, poses substantial challenges in treating a range of infections. The quorum-sensing (QS) system plays a pivotal role in orchestrating the production of a large set of virulence factors in a cell density-dependent manner, and the anti-virulence strategy targeting QS may show huge potential. Here, we present a comprehensive investigation into the potential of the synthesized compound 3-(benzo[d][1,3]dioxol-4-yl)oxazolidin-2-one (OZDO, C₁₀H₉NO₄) as a QS inhibitor to curb the virulence of P. aeruginosa. By employing an integrated approach encompassing in silico screening, in vitro and in vivo functional identification, we elucidated the multifaceted effects of OZDO. Molecular docking predicted that OZDO interfered with three core regulatory proteins of P. aeruginosa QS system. Notably, OZDO exhibited significant inhibition on the production of pyocyanin, rhamnolipid and extracellular proteases, biofilm formation, and cell motilities of P. aeruginosa. Transcriptomic analysis and quantitative real-time PCR displayed the down-regulation of QS-controlled genes in OZDO-treated PAO1, reaffirming the QS-inhibition activity of OZDO. In vivo assessments using a Caenorhabditis elegans-infection model demonstrated OZDO mitigated P. aeruginosa pathogenicity, particularly against the hypervirulent strain PA14. Moreover, OZDO in combination with polymyxin B and aztreonam presented a promising avenue for innovative anti-infective therapy. Our study sheds light on the multifaceted potential of OZDO as an anti-virulence agent and its significance in combating P. aeruginosa-associated infections.

31 Dec 2025·International Journal of Digital Earth

Data-knowledge hybrid driven intelligent prediction method of tunnel excavation profiles geometric deformation

Author: Zhang, Heng ; Zhao, Hongyue ; Hu, Ya ; Zhu, Jun ; Zhang, Huixin ; Lu, Jingyi ; Wu, Jianlin ; Lai, Jianbo ; Ren, Ying ; Zeng, Xiang

100 Deals associated with Chengdu University

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100 Translational Medicine associated with Chengdu University

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Pipeline

Pipeline Snapshot as of 07 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

2

Preclinical

Phase 1 Clinical

2

3

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Cefetamet Sodium ( PBPs )	Pneumonia More	Phase 1
Ceforanide ( PBPs )	Endocarditis More	Phase 1
P2X7 receptor antagonists(Chengdu University) ( P2X7 receptor )	Chronic Kidney Diseases More	Preclinical
C791-0064 ( RAD52 )	Neoplasms More	Preclinical
CN116789628 ( PI3Ks x PI3Kα )	Neoplasms More	Discovery