Delving into the Latest Updates on Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd. with Synapse

Overview

主要目的：评价中国健康受试者空腹单次口服YF-49-92.MLS的安全性及耐受性。次要目的：评价中国健康受试者空腹单次口服YF-49-92.MLS的药代动力学特征。评价食物对中国健康受试者单次口服YF-49-92.MLS的药代动力学和安全性的影响。

[Translation]

Primary objective: To evaluate the safety and tolerability of a single oral fasting dose of YF-49-92.MLS in healthy Chinese subjects. Secondary objective: To evaluate the pharmacokinetic characteristics of a single oral fasting dose of YF-49-92.MLS in healthy Chinese subjects. To evaluate the effect of food on the pharmacokinetics and safety of a single oral fasting dose of YF-49-92.MLS in healthy Chinese subjects.

Start Date16 Oct 2019

Sponsor / Collaborator

Nanjing Changao Pharmaceutical Science & Technology Co. Ltd.

[+1]

100 Clinical Results associated with Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd.

Login to view more data

0 Patents (Medical) associated with Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd.

Login to view more data

3

Literatures (Medical) associated with Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd.

Zhongguo Yiyao Gongye Zazhi

Synthesis of ethyl 2-[6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-ylidene]acetate

Author: Chen, Yilang ; Gao, Fei ; Chen, Youxi

1-(2-Bromoethoxy)-3-iodobenzene (4) was prepared from 3-iodophenol and 1,2-dibromoethane.And Et 5-bromo-2-pen enoate (7) was prepared from propylene glycol by reduction with MnO₂, Witting reaction with Et (triphenylphosphoranylidene) acetate and bromonation.Et 2-[6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-ylidene]acetate, the intermediate of ramelteon, was synthesized from 4 and 7 in the presence of palladium acetate/triphenylphosphine/norbornene with an overall yield of about 51%.

Guangzhou Huagong

Preparation method of (1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine

Author: Wang, Wei ; Wang, Bin-bin

The preparation and optimization of (1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine were studied.(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine was prepared from 3,4-difluoro-bromobenzene via eight steps including Friedel-crafts acylation, stereoselective reduction, cyclization, cyclopropanation, hydrolysis, debromination, amidation and Hoffman elimination.Not only the raw materials and reagents used in the improved process can be found easily in industry, but also the expenses were much lower.It can be found much easier when operating the reaction and purifying and storing the intermediates of each step.The stereo selectivity was higher with fewer wastes, and it was more environmentally friendly.The improved process is more suitable for scale-up of industrial production

Guangzhou Huagong

The synthesis of phenyl-2-amino pyridine derivatives

Author: Zhao, Chuan-sheng

A new route of phenyl-2-amino pyridine derivatives was presented.The desired compound was synthesized through 6 steps which used 1,2,4-trichlorobenzene as starting material and was characterized by ¹H NMR spectra and Ms.Those steps involved Wittig reaction, Staudinger reaction, aza-Wittig reaction, electrocyclic ring-closure of intramol. and 1,3-proton shift, etc.A reasonable reaction mechanism was proposed.The method provided a new way of phenyl-2-amino pyridine derivatives which ware was very difficult to synthesize by coupling.

100 Deals associated with Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd.

Login to view more data

100 Translational Medicine associated with Shanghai SUN-SAIL Pharmaceutical Science & Technology Co., Ltd.

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 20 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

2

Login to view more data