The objective is to optimize the extraction process of sarmentosum tablet and its pharmaceutical formulation. Using orthogonal design method, using quercetin, kaempferol and isorhamnetin in the extract as indexes, the effects of water addition amount, decoction times, boiling time on the extraction were observed By hygroscopicity of Sedum sarmentosum intermediate granules and tablet quality difference and disintegration limit and other quality indicators, the preparation prescription is selected. The preferred extraction processes are: decocting with 10 fold water for 3 times, each for 60 min; the prescription composition is extract powder, microcrystalline cellulose, povidone, magnesium stearate and silica powder. In conclusion, the selected extraction technol. and pharmaceutical formulations are scientific and rational, with stable quality.