Last update 01 Nov 2024

MECP2

Basic Info

Synonyms
MeCp-2 protein, MECP2, mental retardation, X-linked 16
+ [9]
Introduction
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Analysis

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