A Pilot, Single-Masked Study to Compare the Safety and Efficacy of ALZ-1101 (Latanoprost 0.005%/Dorzolamide 2.0%) to Latanoprost Ophthalmic Solution, 0.005% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension With Intraocular Pressure Inadequately Controlled By Latanoprost

This is a pilot, proof of concept study to evaluate the safety and efficacy of ALZ-1101 dosed once daily for 28 days compared to latanoprost 0.005% ophthalmic solution in patients with elevated intraocular pressure not adequately controlled with latanoprost.

Start Date01 Jul 2013

Sponsor / Collaborator

Alleanza Pharmaceuticals, Inc.

NCT00767494

/ TerminatedPhase 3

Travoprost/Brinzolamide Fixed Combination Versus Travatan and Versus AZOPT

The purpose of the study is to compare the IOP lowering efficacy of Travoprost/Brinzolamide dosed daily in the morning or evening, vs TRAVATAN dosed once daily in the evening, and vs. AZOPT dosed BID in patients with open-angle glaucoma or ocular hypertension.

Start Date01 Oct 2008

Sponsor / Collaborator

Alcon Research Ltd.

NCT00767481

/ TerminatedPhase 3

1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT

Parallel, Multi-Center, Double-masked, Active controlled, three arm study comparing the IOP lowering efficacy and safety over 12 months of morning or evening instillations of Travoprost/Brinzolamide vs. Cosopt dosed in the morning and evening in patients with open-angle glaucoma or ocular hypertension.

Start Date01 Oct 2008

Sponsor / Collaborator

Alcon Research Ltd.

[+1]

100 Clinical Results associated with PTGFR x CAs

100 Translational Medicine associated with PTGFR x CAs

0 Patents (Medical) associated with PTGFR x CAs

Literatures (Medical) associated with PTGFR x CAs

01 Mar 1995·International journal of clinical pharmacology and therapeutics

Prostaglandins with vasodilating effects inhibit carbonic anhydrase while vasoconstrictive prostaglandins and leukotriens B4 and C4 increase CA activity.

Article

Author: Coltau, M ; Puscas, I

Previous work carried out by our team in vitro regarding the relationship between prostaglandins (PGs) and carbonic anhydrase (CA) has shown that prostaglandins E1 (PGE1), E2 (PGE2) and I2 (PGI2) inhibit purified bovine red cell CA, as well as human red cell and gastric mucosa CA. This is a completion of our previous research work including kinetic and in vivo studies concerning the relationship between PGs and CA. The relationship between CA and PGE1, E2 and I2, known for their vasodilating and gastric acid secretion (GAS) reducing effects, on the one hand, and between CA and prostaglandin F2 alpha (PGF2 alpha), thromboxans A2 (TXA2), and B4, C4 leukotriens (LTB4, LTC4), known for their vasoconstrictive effects, on the other hand, were studied in vitro. The in vivo studies followed changes induced by vasodilating PGs (misoprostol-analogue of PGE1, nalador-analogue of PGE2, ilomedin-analogue of PGI2) and vasoconstrictive-minprostin analogue of PGF2 alpha on red cell CA, correlated to modifications of arterial blood pressure (BP). Results obtained in vitro show that PGE1, E2, I2 inhibits basal CA activity, while PGF2 alpha, TXA2 and LTB4, LTC4 increase the activity of the enzyme. Kinetic assessments show that the inhibition and the activation mechanism is a direct one of the non-competitive type located on the active site of CA. Data obtained in vivo show that administration of a single therapeutic dose of misoprostol, nalador or ilomedin inhibits basal activity of CA by 35-55% with corresponding decrease of BP values.(ABSTRACT TRUNCATED AT 250 WORDS)

01 Apr 1989·Nihon Sanka Fujinka Gakkai zasshi

[Kinetics of catecholamines in amniotic fluid implicated with onset of labor pain].

Article

Author: Nishimura, N

There are several controversies related to labor initiation in term. I therefore tried to analyse the relationship between the onset of labor and the dynamics of catecholamine-concentrations in amniotic fluid using the LC-EC method. Results are as follows. 1. Dopamine levels in amniotic fluid increased with gestational age. 2. Norepinephrine and Dopamine levels were higher in women with uterine contraction than in those without uterine contraction. 3. PGF2 alpha production in amnion increased significantly when it was incubated thirty minutes with CAs compared to that incubated only with Hanks' BSS. The PGE production rate in amnion was five or six times as great as that in PGF2 alpha. In conclusion, it is supposed that CAs in amniotic fluid may play a role in the initiation of uterine contraction.

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