Synonyms FP, FP prostanoid receptor, PGF receptor + [6] |
Introduction Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. |
Target |
Mechanism PTGFR agonists [+2] |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date12 Mar 2019 |
Target |
Mechanism PTGFR agonists [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date02 Nov 2017 |
Mechanism PTGFR agonists [+2] |
Active Org. |
Originator Org. |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date28 Sep 2016 |
Start Date04 Sep 2024 |
Sponsor / Collaborator |
Start Date21 Aug 2024 |
Sponsor / Collaborator |
Start Date24 Jun 2024 |
Sponsor / Collaborator |