Synonyms 3-ketoacyl-CoA thiolase, mitochondrial, ACAA2, Acetyl-CoA acetyltransferase + [8]  | 
Introduction In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312).  | 
Target  | 
Mechanism ACAA2 inhibitors  | 
Active Org.  | 
Originator Org.  | 
Active Indication  | 
Inactive Indication  | 
Drug Highest PhaseApproved  | 
First Approval Ctry. / Loc. Japan  | 
First Approval Date31 Jan 1968  | 
Start Date01 Sep 2024  | 
Sponsor / Collaborator  | 
Start Date20 Aug 2024  | 
Sponsor / Collaborator  | 
Start Date07 Jul 2024  | 
Sponsor / Collaborator-  | 
