Acute-On-Chronic Liver Failure

First project will prioritise the discovery and development of a key human cell type for Parkinson’s disease (PD) research and drug discovery. Collaboration agreement allows MJFF to fund specific projects under which bit.bio will develop a range of human iPSC-derived cell products for PD. Products created under the collaboration agreement will offer researchers a physiologically-relevant and defined source of human cells for drug screening and disease modelling, and to further the fundamental understanding of PD pathology. The collaboration with MJFF leverages both bit.bio’s discovery platform to identify transcription factor (TF) combinations and bit.bio’s opti-ox™ technology for the deterministic reprogramming of iPSCs into mature, functional human cells. CAMBRIDGE, England--(BUSINESS WIRE)-- bit.bio, the company coding human cells for novel cures, today announces the first project within a multi-year collaboration agreement with The Michael J. Fox Foundation for Parkinson's Research (MJFF) to prioritise the development and delivery of a range of human cell products relevant to Parkinson’s disease (PD). Under the terms of the collaboration agreement, both wild type human cells and physiologically relevant disease model cells can be generated through individual project agreements. Funding to bit.bio by MJFF will be allocated on a project-by-project basis. The first project has been agreed and will prioritise the discovery of TF combinations for a relevant human cell type in PD and the development of that cell type into a product for the PD research community. PD occurs when dopaminergic neurons stop working or die. PD is a lifelong and progressive disease, and beyond movement disorders such as tremor, slowness, stiffness and balance problems, it can cause depression and memory loss. PD affects 1–2% of the population over the age of 65 and it is estimated that cases will exceed 12 million individuals in 2040.1 It is a complex and heterogeneous disease affected by multiple genetic and environmental factors. Currently, Parkinson’s disease researchers mostly rely on animal models and human iPSC-derived dopaminergic neurons, generated via directed differentiation protocols. These protocols present significant drawbacks as they are lengthy, difficult to reproduce and yield heterogeneous populations. Having access to a consistent and scalable source of physiologically relevant human cell models will help researchers understand and pinpoint the diverse pathways that lead to loss of dopaminergic neurons, and gain essential insights into specific cellular and molecular mechanisms involved in disease pathogenesis. Nicole K. Polinski, PhD, Director of Research Resources, MJFF said: “We are thrilled to partner with bit.bio and to leverage the company’s unique platform for the generation of human cells. Parkinson’s disease researchers urgently need accessible and well-characterised tools to improve our understanding of PD, and to help deliver therapeutic breakthroughs. The consistency and scalability of bit.bio’s human cell products will provide a very important addition to the suite of tools we know to be necessary.” All bit.bio ioCellsTM products, including those to be developed under the partnership with MJFF, are precision reprogrammed using bit.bio’s opti-ox technology. As such they are defined human cells that have inherent experimental scalability, offer unparalleled biological consistency and are simple to handle and culture. Mark Kotter, CEO, bit.bio said: “This important collaboration with MJFF gives us the opportunity to accelerate the development and delivery of a series of human cell types and associated disease models to the PD research community. The work that MJFF has done to advance the understanding and treatment of PD has been groundbreaking. The team here at bit.bio is already working to deliver the first cell product under the collaboration framework and we are delighted to join with MJFF on this essential path.” Notes to Editors References 1. About bit.bio bit.bio is a synthetic biology company focused on human cells that is advancing medicine (UN SDG9) and enabling curative treatments (UN SDG3). The company does this by industrialising the manufacture of human cells and making them more accessible. The company was spun out of the University of Cambridge in 2016 and has since raised approximately $200m from investors such as Arch Venture, Foresite Capital, Milky Way, Charles River Laboratories, National Resilience, Tencent, Verition Fund and Puhua Capital. bit.bio’s opti-ox™ precision cell programming and manufacturing technology enables conversion of induced pluripotent stem cells (iPSCs) into any desired human cell type in a single step. This can be achieved within days and at industrial scale, while maintaining exceptional purity and unparalleled consistency. Our discovery platform extends this approach to any desired cell type by identifying the transcription factor combinations that define cell states (including identity, cell subtype identity, maturity) using high throughput screens and advanced data analysis. We believe that opti-ox can revolutionise regenerative medicine similarly to how CRISPR is unlocking gene therapy. bit.bio’s cell therapy pipeline, based on txCells™, is focused on serious diseases that lack effective treatments. Our current therapeutic development areas include metabolism and endocrinology, immunology and neurology. Our lead candidate, bbHEP01 based on txHepatocytes, is in development as a treatment for patients suffering from acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Complementing our internal pipeline, we have a collaboration with BlueRock Therapeutics (a wholly owned independently operated subsidiary of Bayer AG) focused on regulatory T cell (Treg) based cell therapies. In addition, our extensive ioCells™ research cell product portfolio, which includes ioWild Type Cells™, ioDisease Model Cells™ and ioCRISPR-Ready Cells™, is opening up new possibilities for studying human biology and developing new medicines in both research and high-throughput and high-content drug discovery. For more information, please visit View source version on businesswire.com: Contacts Media Chris Hempel Spark Public Relations chris.hempel@sparkpr.com +1-775-813-0285 Investors Mike Booth, SVP External Affairs, bit.bio ir@bit.bio +44 1223 787297 Source: bit.bio View this news release online at:

Cash and cash equivalents totaled €77.8 million as of December 31, 2023Revenues amounted to €28.6 million as of December 31, 2023 including a milestone payment of €13.3 million Upcoming FDA PDUFA action date for elafibranor in PBC: June 10, 2024 Lille (France), Cambridge (Massachusetts, United States), Zurich (Switzerland), February 29, 2024 - GENFIT (Nasdaq and Euronext: GNFT), a late-stage biopharmaceutical company dedicated to improving the lives of patients with rare and life-threatening liver diseases, today announced its cash position as of December 31, 2023 and revenues for 2023. Cash Position As of December 31, 2023, the Company’s cash and cash equivalents amounted to €77.8 million compared with €140.2 million as of December 31, 2022. As of September 30, 2023, cash and cash equivalents totaled €93.9 million. This amount does not include the receipt in February 2024 of a €13.3 million milestone payment from Ipsen, which was invoiced in December 2023, triggered by the acceptance of the New Drug Application (NDA) filing by the US Food and Drug Administration (FDA) and Marketing Authorization Application (MAA) by the European Medicines Agency (EMA) for accelerated approval of elafibranor in Primary Biliary Cholangitis (PBC) in December 2023. As previously indicated in past communications1, in 2024 GENFIT expects to receive total milestone payments of approximately €89 million (including the €13.3 milestone already received in February 2024), subject to the approval and commercialization of elafibranor in PBC. The decrease in cash and cash equivalents between September 30, 2023, and December 31, 2023, takes into account our continued research and development efforts, notably for: UNVEIL-IT™, our Phase 2 clinical trial evaluating VS-01 in Acute-on-Chronic Liver Failure (ACLF); our cholangiocarcinoma program evaluating GNS561; our ACLF program evaluating NTZ; our non-clinical trial of SRT-015 in ACLF; and ELATIVE®, specifically the portion of the Phase 3 clinical trial evaluating elafibranor in PBC that has not yet been transferred to Ipsen. We expect that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements until approximately the fourth quarter of 2025. This is based on current assumptions and programs, and does not include exceptional events. This estimation includes our expectations to receive future milestone revenue in 2024, subject to approval by applicable regulatory authorities and US and European commercial launches of elafibranor in PBC by Ipsen, representing a total of approximately €75.2 million. Revenues Revenues for 2023 amounted to €28.6 million compared to €20.2 million for the same period in 2022. Of the €28.6 million, €13.3 million was attributable to a milestone payment invoiced to Ipsen in December 2023 in accordance with the Collaboration and Licensing agreement signed in December 2021. This milestone payment was earned following the NDA filing acceptance by the FDA and MAA filing acceptance by the EMA for accelerated approval of elafibranor. €8.7 million in revenue was attributable to the partial recognition of the €40.0 million deferred income as described below. €6.5 million in revenue was generated from the services rendered under the Transition Services Agreement and Part B Transition Services Agreement, signed in April 2022 and September 2023 respectively by GENFIT and Ipsen, in order to facilitate the transition of certain services related to the Phase 3 ELATIVE® clinical trial until the complete transfer of the responsibility of the trial to Ipsen. €0.1 million was attributable to other ancillary activities. Of the €20.2 million in revenues for 2022, €15.9 million was attributable to the partial recognition of the €40.0 million deferred income per IFRS2 15 in accordance with the Collaboration and Licensing Agreement signed with Ipsen in 2021. €1.0 million in revenue was generated from services rendered by GENFIT to Ipsen in accordance with the Transition Services Agreement signed in 2022. €3.3 million was recognized as revenue in accordance with the Inventory Purchase Agreement signed with Ipsen in 2022, under which the Company sold almost all of its remaining stock of elafibranor’s active ingredient and drug products for the ELATIVE® Phase 3 clinical trial to Ipsen. Upcoming FDA PDUFA3 Action Date for Elafibranor in PBC: June 10, 2024 Regulatory filing acceptance has been obtained in the US, Europe and the United Kingdom4 and a Priority Review has been granted for an NDA by the FDA for elafibranor in PBC with a PDUFA target action date of June 10, 2024. Upcoming Financial Communications The Company will release its full-year 2023 financial results on April 4, 2024. The 2023 Universal Registration Document, the 2023 Annual Financial Report (included in the 2023 Universal Registration Document), and the Annual Report on Form 20-F will be published by the end of April 2024. ABOUT GENFIT GENFIT is a late-stage biopharmaceutical company dedicated to improving the lives of patients with rare and life-threatening liver diseases characterized by high unmet medical needs. GENFIT is a pioneer in liver disease research and development with a rich history and strong scientific heritage spanning more than two decades. Today, GENFIT has a growing and diversified pipeline with programs at various development stages. The Company’s area of focus is Acute-on-Chronic Liver Failure (ACLF). Its ACLF franchise consists of five assets in development: VS-01, NTZ, SRT-015, CLM-022 and VS-02-HE. These are all based on differentiated mechanisms of action leveraging complementary pathways. Other assets target other life-threatening disease indications such as cholangiocarcinoma (CCA) and Urea Cycle Disorders (UCD)/Organic Acidemias (OA). GENFIT’s track record in bringing early-stage assets with high potential to late development and pre-commercialization stages is highlighted in the successful 52-week Phase 3 ELATIVE® trial evaluating elafibranor in PBC. Beyond therapeutics, GENFIT’s pipeline also includes a diagnostic franchise focused on Metabolic dysfunction-associated steatohepatitis (MASH) previously known as nonalcoholic steatohepatitis (NASH) and ammonia. GENFIT has facilities in Lille and Paris (France), Zurich (Switzerland) and Cambridge, MA (USA). GENFIT is a publicly traded company listed on the Nasdaq Global Select Market and on compartment B of Euronext’s regulated market in Paris (Nasdaq and Euronext: GNFT). In 2021, Ipsen became one of GENFIT’s largest shareholders and holds 8% of the company’s share capital. For more information, visit www.genfit.com FORWARD LOOKING STATEMENTS This press release contains certain forward-looking statements, including those within the meaning of the Private Securities Litigation Reform Act of 1995 with respect to GENFIT, including, but not limited to statements about the Company’s eligibility to receive future milestone payments from Ipsen relating to the development and commercial launch of elafibranor in PBC, approval of elafibranor in PBC and potential commercialization as early as 2024, and expected cash runway. The use of certain words, including “believe”, “potential,” “expect”, “target”, “may” and “will” and similar expressions, is intended to identify forward-looking statements. Although the Company believes its expectations are based on the current expectations and reasonable assumptions of the Company’s management, these forward-looking statements are subject to numerous known and unknown risks and uncertainties, which could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking statements. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including in relation to safety of drug candidates, cost of, progression of, and results from, our ongoing and planned clinical trials, review and approvals by regulatory authorities in the United States, Europe and worldwide, of our drug and diagnostic candidates, potential commercial success of elafibranor if approved, exchange rate fluctuations, our continued ability to raise capital to fund our development, as well as those risks and uncertainties discussed or identified in the Company’s public filings with the AMF, including those listed in Chapter 2 “Main Risks and Uncertainties” of the Company’s 2022 Universal Registration Document filed with the AMF on April 18, 2023, which is available on the Company’s website (www.genfit.com) and on the website of the AMF (www.amf-france.org) and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”) including the Company’s 2022 Annual Report on Form 20-F filed with the SEC on April 18, 2023 and subsequent filings and reports filed with the AMF or SEC, including the Half-Year Business and Financial Report at June 30, 2023 or otherwise made public, by the Company. In addition, even if the Company’s results, performance, financial condition and liquidity, and the development of the industry in which it operates are consistent with such forward-looking statements, they may not be predictive of results or developments in future periods. These forward-looking statements speak only as of the date of publication of this document. Other than as required by applicable law, the Company does not undertake any obligation to update or revise any forward-looking information or statements, whether as a result of new information, future events or otherwise. CONTACT GENFIT | Investors Tel: +33 3 2016 4000 | investors@genfit.com PRESS RELATIONS | Media Stephanie Boyer – Press relations | Tel: +333 2016 4000 | stephanie.boyer@genfit.com 1 GENFIT Updates 2024 Outlook Following Acceptance of Elafibranor Filings in Primary Biliary Cholangitis (PBC)2 International Financial Reporting Standards3 Prescription Drug User Fee Act4 Ipsen confirms U.S. FDA grants priority review for New Drug Application for elafibranor for the treatment of rare cholestatic liver disease, PBCGENFIT | 885 Avenue Eugène Avinée, 59120 Loos - FRANCE | +333 2016 4000 | www.genfit.com Attachment GENFIT Announces Revenues and Cash Position as of December 31, 2023

The Ginkgo Technology Network brings together over 25 diverse partners across an array of capabilities including AI, genetic medicines, biologics, and manufacturing. As a Ginkgo Technology Network partner, bit.bio’s ioCells™ portfolio of precision reprogrammed human cells for research and drug discovery will now be available within Ginkgo’s platform ecosystem. Integration of the ioCells research product portfolio could enable new workflows for Ginkgo’s biopharma clients; by providing physiologically-relevant human cell models at scale, we expect Ginkgo clients will be able to drive insights into disease biology and accelerate preclinical research and drug discovery. CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)-- bit.bio, the company coding human cells for novel cures, and Ginkgo Bioworks (NYSE: DNA), which is building the leading platform for cell programming and biosecurity, today announced bit.bio as an inaugural partner of the Ginkgo Technology Network. The Network, launched today, is a groundbreaking ecosystem of cutting edge technology partners, committed to collaborating with Ginkgo to provide new, integrated capabilities to drive success in customer R&D programs. As a Network partner, bit.bio’s ioCells portfolio of human cells for research and drug discovery can be integrated into Ginkgo’s platform ecosystem. bit.bio’s ioCells products are precision reprogrammed from iPSCs using bit.bio’s opti-oxTM technology. They are defined human cells that have inherent experimental scalability, offer unparallelled consistency and are simple to handle and culture. Jason Kelly, CEO and co-founder, Ginkgo Bioworks said: “We’re very excited to partner with bit.bio to enable more disease-relevant results for our customers. With bit.bio’s unique ioCells portfolio of human cells, our customers will be able to conduct research and drug development on physiologically-relevant human cell models across our ecosystem. We’re hopeful that use of these robust human cell models may increase the potential for successful translation of our customers' therapeutic candidates from early drug discovery, preclinical research through clinical trials, to ultimately deliver the next generation of lifesaving therapeutics. We’re proud to put the full force of our automated Foundry behind bit.bio’s ioCells product portfolio.” bit.bio and Ginkgo believe that their products and services complement each other, yielding better R&D results for customers. Ginkgo's customers will be able to benefit from the use of ioCells to conduct research into disease mechanisms and screen for novel therapeutic targets. There are almost 30 products in the ioCells range with many more expected to be launched in 2024 and beyond. Mark Kotter, CEO and founder, bit.bio said: “I am excited to see two leading synthetic biology companies join forces to bring unique technologies to our customers and increase research and development efficiency. Ginkgo has a unique capability within its ecosystem to integrate diverse experimental and computational technologies that deliver on complex customer needs. We are excited to add ioCells to that offering. Our opti-ox programmed human cell products are unrivalled with regard to cell function, scalability and consistency. This enables significantly increased experimental accuracy for our customers - product features which Ginkgo’s clients can now access through our new Technology Network.” Ginkgo is uniquely positioned to act as a “systems integrator” for the biotech ecosystem, offering customers a much more unified experience. As a platform company, Ginkgo makes customer-driven infrastructure investments and is incentivised to make its tools and capabilities available to customers. Ginkgo’s programs require the integration of both existing capabilities and new techniques and approaches. This approach to biology allows customers to access a range of technical approaches rather than feel constrained by the status quo. Notes to Editors About the Ginkgo Technology Network Read the full press release on the Network, including all inaugural partners here About bit.bio bit.bio is a synthetic biology company focused on human cells that is advancing medicine (UN SDG9) and enabling curative treatments (UN SDG3). The company does this by industrialising the manufacture of human cells and making them more accessible. The company was spun out of the University of Cambridge in 2016 and has since raised approximately $200m from investors such as Arch Venture, Foresite Capital, Milky Way, Charles River Laboratories, National Resilience, Tencent, Verition Fund and Puhua Capital. bit.bio’s opti-ox™ precision cell programming and manufacturing technology enables conversion of induced pluripotent stem cells (iPSCs) into any desired human cell type in a single step. This can be achieved within days and at industrial scale, while maintaining exceptional purity and unparalleled consistency. Our discovery platform extends this approach to any desired cell type by identifying the transcription factor combinations that define cell states (including identity, cell subtype identity, maturity) using high throughput screens and advanced data analysis. We believe that opti-ox can revolutionise regenerative medicine similarly to how CRISPR is unlocking gene therapy. bit.bio’s cell therapy pipeline, based on txCells™, is focused on serious diseases that lack effective treatments. Our current therapeutic development areas include metabolism and endocrinology, immunology and neurology. Our lead candidate, bbHEP01 based on txHepatocytes, is in development as a treatment for patients suffering from acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Complementing our internal pipeline, we have a collaboration with BlueRock Therapeutics (a wholly owned independently operated subsidiary of Bayer AG) focused on regulatory T cell (Treg) based cell therapies. In addition, our extensive ioCells™ research cell product portfolio, which includes ioWild Type Cells™, ioDisease Model Cells™ and ioCRISPR-Ready Cells™, is opening up new possibilities for studying human biology and developing new medicines in both research and high-throughput and high-content drug discovery. For more information, please visit About Ginkgo Bioworks Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo's biosecurity and public health unit, Concentric by Ginkgo, is building global infrastructure for biosecurity to empower governments, communities, and public health leaders to prevent, detect and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and concentricbyginkgo.com, read our blog, or follow us on social media channels such as X (formerly known as Twitter) (@Ginkgo and @ConcentricByGBW), Instagram (@GinkgoBioworks), Threads (@GinkgoBioworks) or LinkedIn. Forward-Looking Statements of Ginkgo Bioworks This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding the capabilities and potential success of Ginkgo's cell programming platform and the capabilities and potential growth of the Ginkgo Technology Network. These forward-looking statements generally are identified by the words "believe," "can," "project," "potential," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) volatility in the price of Ginkgo's securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Ginkgo operates and plans to operate, variations in performance across competitors, and changes in laws and regulations affecting Ginkgo's business, (ii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional business opportunities, (iii) the risk of downturns in demand for products using synthetic biology, (iv) the uncertainty regarding the demand for passive monitoring programs and biosecurity services, (v) changes to the biosecurity industry, including due to advancements in technology, emerging competition and evolution in industry demands, standards and regulations, (vi) our ability to realize the expected benefits of merger and acquisition transactions, (vii) the outcome of any legal proceedings against Ginkgo, including as a result of recent acquisitions, (viii) our ability to realize the expected benefits from and the success of our Foundry platform programs, (ix) our ability to successfully develop engineered cells, bioprocesses, data packages or other deliverables, and (x) the product development or commercialization success of our customers. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the "Risk Factors" section of Ginkgo's quarterly report on Form 10-Q filed with the U.S. Securities and Exchange Commission (the "SEC") on November 8, 2023 and other documents filed by Ginkgo from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Ginkgo assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Ginkgo does not give any assurance that it will achieve its expectations.