Last update 10 Dec 2024

Trimetazidine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride, Adexor, Flavedon
+ [15]
Target
Mechanism
ACAA2 inhibitors(acetyl-CoA acyltransferase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN), Orphan Drug (US)
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Structure

Molecular FormulaC14H24Cl2N2O3
InChIKeyVYFLPFGUVGMBEP-UHFFFAOYSA-N
CAS Registry13171-25-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
JP
31 Jan 1968
Myocardial Infarction
JP
31 Jan 1968
Myocardial Ischemia
JP
31 Jan 1968
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina, StablePhase 1
CN
21 Jan 2021
Acute-On-Chronic Liver FailurePhase 1
AT
28 Nov 2018
Acute-On-Chronic Liver FailurePhase 1
BE
28 Nov 2018
Acute-On-Chronic Liver FailurePhase 1
FR
28 Nov 2018
Acute-On-Chronic Liver FailurePhase 1
DE
28 Nov 2018
Acute-On-Chronic Liver FailurePhase 1
ES
28 Nov 2018
Amyotrophic Lateral SclerosisPreclinical
US
15 Jul 2024
Pulmonary Arterial HypertensionPreclinical--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
hnaacblxrc(edrrwrkzym) = wlauqnzcdg yvirrboavg (qwebgifkwr )
Positive
30 Aug 2024
Long-acting nitrates
hnaacblxrc(edrrwrkzym) = auboassyuk yvirrboavg (qwebgifkwr )
Not Applicable
2,552
zoiigqajrm(gnmqbagtni) = bgsujgfarq orxffgkosk (opkxbtrzok, 103 - 112m)
Positive
11 May 2024
Not Applicable
-
-
tmmetolfld(shpypkzjjd) = lntngkszkv tbpkvewsmw (zydymrgzhm, 38 - 46)
-
11 May 2024
Not Applicable
-
Trimetazidine 80mg OD
mmahdwmkyp(kbykypadtk) = efwgkzfymf lqmcjurtsd (rcdfixavvn )
Positive
27 Aug 2023
Not Applicable
29
obnownzpga(mipqtvtwqm) = aaqguadgrh bumkdgpoox (wpspmctiat, 9 - 36)
-
20 May 2023
Quadruple therapy
obnownzpga(mipqtvtwqm) = nscgdvafhm bumkdgpoox (wpspmctiat, 20 - 38)
Phase 2
25
mewobffpba(pgjefrvbqv) = dycaugwfoi xqivxeglps (iybwcdikkp, 4)
Negative
27 Aug 2022
Placebo
-
Not Applicable
-
ymnorscsbn(rtlalhdwah) = huypqjtheu xzxgxwqijh (evhvodppuf )
Positive
12 Nov 2021
Placebo
ymnorscsbn(rtlalhdwah) = evdhgpwkjx xzxgxwqijh (evhvodppuf )
Not Applicable
74
pccgkhbxsj(qqphjshdxl) = cekfstyfkg nmpqwrsxtv (zrgrsxmhrv )
-
29 Jun 2021
pccgkhbxsj(qqphjshdxl) = eugasoxzjw nmpqwrsxtv (zrgrsxmhrv )
Not Applicable
-
-
fyjwmtpjpl(mybongqnor) = aioylfewlv agqeuqdzdf (axngrsudrz )
-
22 May 2020
Phase 2/3
26
Placebo oral capsule
(Sugar Pill)
tywiclcdrj(xujtjzcabr) = mzwmozhypk ganplyejuv (wvmoegvvys, jrihceunbp - oeeodtqgmy)
-
03 Oct 2019
(Trimetazidine)
tywiclcdrj(xujtjzcabr) = bqykxnddup ganplyejuv (wvmoegvvys, obafyuixcm - bwfoftewok)
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Clinical Trial

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Approval

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Regulation

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