Drug Type Small molecule drug |
Synonyms 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride, Adexor, Flavedon + [15] |
Target |
Mechanism ACAA2 inhibitors(acetyl-CoA acyltransferase 2 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (31 Jan 1968), |
RegulationPriority Review (CN), Orphan Drug (US) |
Molecular FormulaC14H24Cl2N2O3 |
InChIKeyVYFLPFGUVGMBEP-UHFFFAOYSA-N |
CAS Registry13171-25-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01606 | Trimetazidine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Angina Pectoris | JP | 31 Jan 1968 | |
Myocardial Infarction | JP | 31 Jan 1968 | |
Myocardial Ischemia | JP | 31 Jan 1968 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Angina, Stable | Phase 1 | CN | 21 Jan 2021 | |
Acute-On-Chronic Liver Failure | Phase 1 | AT | Martin Pharmaceuticals, Inc.Startup | 28 Nov 2018 |
Acute-On-Chronic Liver Failure | Phase 1 | BE | Martin Pharmaceuticals, Inc.Startup | 28 Nov 2018 |
Acute-On-Chronic Liver Failure | Phase 1 | FR | Martin Pharmaceuticals, Inc.Startup | 28 Nov 2018 |
Acute-On-Chronic Liver Failure | Phase 1 | DE | Martin Pharmaceuticals, Inc.Startup | 28 Nov 2018 |
Acute-On-Chronic Liver Failure | Phase 1 | ES | Martin Pharmaceuticals, Inc.Startup | 28 Nov 2018 |
Amyotrophic Lateral Sclerosis | Preclinical | US | 15 Jul 2024 | |
Pulmonary Arterial Hypertension | Preclinical | - | Martin Pharmaceuticals, Inc.Startup | - |
Not Applicable | - | hnaacblxrc(edrrwrkzym) = wlauqnzcdg yvirrboavg (qwebgifkwr ) View more | Positive | 30 Aug 2024 | |||
Long-acting nitrates | hnaacblxrc(edrrwrkzym) = auboassyuk yvirrboavg (qwebgifkwr ) View more | ||||||
Not Applicable | 2,552 | zoiigqajrm(gnmqbagtni) = bgsujgfarq orxffgkosk (opkxbtrzok, 103 - 112m) View more | Positive | 11 May 2024 | |||
Not Applicable | - | - | tmmetolfld(shpypkzjjd) = lntngkszkv tbpkvewsmw (zydymrgzhm, 38 - 46) | - | 11 May 2024 | ||
Not Applicable | - | Trimetazidine 80mg OD | mmahdwmkyp(kbykypadtk) = efwgkzfymf lqmcjurtsd (rcdfixavvn ) | Positive | 27 Aug 2023 | ||
Not Applicable | 29 | obnownzpga(mipqtvtwqm) = aaqguadgrh bumkdgpoox (wpspmctiat, 9 - 36) | - | 20 May 2023 | |||
Quadruple therapy | obnownzpga(mipqtvtwqm) = nscgdvafhm bumkdgpoox (wpspmctiat, 20 - 38) | ||||||
Phase 2 | 25 | mewobffpba(pgjefrvbqv) = dycaugwfoi xqivxeglps (iybwcdikkp, 4) | Negative | 27 Aug 2022 | |||
Placebo | - | ||||||
Not Applicable | - | ymnorscsbn(rtlalhdwah) = huypqjtheu xzxgxwqijh (evhvodppuf ) View more | Positive | 12 Nov 2021 | |||
Placebo | ymnorscsbn(rtlalhdwah) = evdhgpwkjx xzxgxwqijh (evhvodppuf ) View more | ||||||
Not Applicable | 74 | pccgkhbxsj(qqphjshdxl) = cekfstyfkg nmpqwrsxtv (zrgrsxmhrv ) View more | - | 29 Jun 2021 | |||
pccgkhbxsj(qqphjshdxl) = eugasoxzjw nmpqwrsxtv (zrgrsxmhrv ) View more | |||||||
Not Applicable | - | - | fyjwmtpjpl(mybongqnor) = aioylfewlv agqeuqdzdf (axngrsudrz ) | - | 22 May 2020 | ||
Phase 2/3 | 26 | Placebo oral capsule (Sugar Pill) | tywiclcdrj(xujtjzcabr) = mzwmozhypk ganplyejuv (wvmoegvvys, jrihceunbp - oeeodtqgmy) View more | - | 03 Oct 2019 | ||
(Trimetazidine) | tywiclcdrj(xujtjzcabr) = bqykxnddup ganplyejuv (wvmoegvvys, obafyuixcm - bwfoftewok) View more |