Synonyms Aggressive NK Cell Leukemia, Aggressive Natural Killer Cell Leukemia, Granular Lymphocytoses, Large + [90] |
Introduction A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. |
Target |
Mechanism PI3Kδ inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. China |
First Approval Date08 Nov 2022 |
Target |
Mechanism PI3Kγ inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date24 Sep 2018 |
Target |
Mechanism Bcl-2 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date11 Apr 2016 |
Start Date02 Jun 2025 |
Sponsor / Collaborator |
Start Date15 Dec 2024 |
Sponsor / Collaborator |
Start Date10 Aug 2024 |
Sponsor / Collaborator |