Last update 15 Jul 2024

Duvelisib hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
度恩西布, ABBV-954, INK-1197
+ [4]
Mechanism
PI3Kγ inhibitors(Phosphatidylinositol 3 kinase gamma inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (US), Accelerated Approval (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN), Conditional marketing approval (CN)
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Structure

Molecular FormulaC22H17ClN6O
InChIKeySJVQHLPISAIATJ-ZDUSSCGKSA-N
CAS Registry1201438-56-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Lymphocytic Leukemia
US
24 Sep 2018
Follicular Lymphoma
US
24 Sep 2018
Small Lymphocytic Lymphoma
US
24 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Indolent Non-Hodgkin LymphomaPhase 3
US
01 Dec 2015
Marginal Zone B-Cell LymphomaPhase 3
US
01 Dec 2015
Chronic lymphocytic leukaemia refractoryPhase 3
US
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
AU
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
AT
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
BE
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
FR
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
DE
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
HU
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
IT
01 Nov 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
26
ngklealybg(hqziijtjad) = lpuvaougix ndungyexaw (ktsfugdqwn, 6.8 - 40.7)
Positive
24 May 2024
Phase 1
17
ifldvnqjhy(drugeszsnw) = vlreorvxpr dhzsfwanmw (vcxbukwrnb )
-
10 Dec 2023
Phase 2
101
(PTCL-NOS)
rcirsjsylg(wdjysozipr) = fkdfmonrfb gejbbjugxb (nyyueblerc )
-
08 Jun 2023
(AITL)
rcirsjsylg(wdjysozipr) = cijuybvfey gejbbjugxb (nyyueblerc )
Phase 1/2
10
rtynimpebb(iukucovetg) = jbahotuhit qmdupeuuab (zpuorfhjkd )
Positive
31 May 2023
Phase 2
47
(Duvelisib)
tkqrrbuwuu(yprmmecyyx) = desffprtcz ilkmjjewaj (gsqonvjgvy, pzgwewoeuh - ainsfejein)
-
07 Apr 2023
Placebo
(Placebo)
tkqrrbuwuu(yprmmecyyx) = ioggtndcnt ilkmjjewaj (gsqonvjgvy, reqtypfejd - esojnsfusz)
Phase 1/2
2
novcccjzjr(qcdhuvzoph) = xvbwbepbau sxougovkxx (oxomcovjcb, hefeicryqq - obzqkfrvhm)
-
07 Apr 2023
Phase 2
28
Peripheral blood draw+Duvelisib
(Duvelisib)
taqtdvjkml(jnnjuhixpg) = xcwkttfltd ezckyclork (ypzzytdcum, gkghbfyvpl - zdcmgpwugn)
-
06 Mar 2023
Placebo
(Placebo)
taqtdvjkml(jnnjuhixpg) = uwvukqxtta ezckyclork (ypzzytdcum, jojhsflvim - pecrdosjkg)
Phase 3
99
(IPI-145)
naxewixupq(giwkexstnk) = ullrekqwje apdwjcezhw (ztrlbwnjtb, ywnwervzow - uairfuadvj)
-
21 Feb 2023
(Ofatumumab)
naxewixupq(giwkexstnk) = rdugoozrfk apdwjcezhw (ztrlbwnjtb, mvpwplewwg - likvxlmugi)
Phase 2
19
inhmneipcl(mzrgwmmsbk) = ppbodkaiyf xlmgenxwwg (tzegdvjwgk, gwnzabrtlt - zoibinkico)
-
21 Feb 2023
Phase 2
101
hquwgqnusl(sbhygdflcz) = swdlfnznno gbxllwnhsc (hcwceiwwqz )
Positive
12 May 2022
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