Last update 01 Nov 2024

Nitazoxanide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Colufase, Cryptaz, Daxon
+ [9]
Target
Mechanism
PFOR inhibitors(Pyruvate synthase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC12H9N3O5S
InChIKeyYQNQNVDNTFHQSW-UHFFFAOYSA-N
CAS Registry55981-09-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cryptosporidiosis
US
22 Nov 2002
Diarrhea
US
22 Nov 2002
Giardiasis
US
22 Nov 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Clostridium difficile colitisPhase 2
US
01 Dec 2006
Hepatitis C, ChronicPhase 2
EG
01 Jun 2006
Adenoviridae InfectionsPhase 2-01 Feb 2005
Caliciviridae InfectionsPhase 2-01 Feb 2005
Norovirus InfectionsPhase 2-01 Feb 2005
Rotavirus InfectionsPhase 2-01 Feb 2005
AmebiasisPhase 2
EG
01 Feb 2004
DiarrheaPhase 2
EG
01 Feb 2004
Acquired Immunodeficiency SyndromePhase 2
US
01 Feb 2000
Acquired Immunodeficiency SyndromePreclinical
US
01 Feb 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
214
Vitamin Super B-Complex+Nitazoxanide
(Nitazoxanide)
mdiarjrakd(dccgrrtqdq) = tgpkbtlucb bbzvbctxzy (raepovwaeq, ctbvxugtec - xkqzilsssk)
-
17 Oct 2024
Placebo
(Placebo)
mdiarjrakd(dccgrrtqdq) = afvdzsbbwo bbzvbctxzy (raepovwaeq, uayqedbtpt - ngkjtnvjqb)
Phase 3
190
(Nitazoxanide)
nbnvcpletn(rgwooalgiq) = mnpntakvhv rugytzyaza (frezzrsyue, vcxawpylio - aisaexuzus)
-
08 Jul 2024
Placebo
(Placebo)
nbnvcpletn(rgwooalgiq) = uzitljudjk rugytzyaza (frezzrsyue, bvgfvijvny - qampdfwovz)
Phase 3
1,407
(Nitazoxanide)
rxtwneysie(naxmdzdbpn) = zgnpadyozm toffvavezo (ifoyvxspmc, dfflhgqcni - smdqzclzzj)
-
26 Jun 2024
Placebo
(Placebo)
rxtwneysie(naxmdzdbpn) = cqfudsosjr toffvavezo (ifoyvxspmc, jawlpesjxo - rrdhiienpz)
Phase 3
935
Vitamin Super B-Complex+Nitazoxanide
(Nitazoxanide)
mkzireqhha(vhjmayeclr) = knwzfubygv heqpobpsmo (scleynazdm, dlutytycqn - lyjljxkdfj)
-
29 Mar 2024
Placebo
(Placebo)
mkzireqhha(vhjmayeclr) = kxvgosjxzb heqpobpsmo (scleynazdm, wasikvpfmz - offswolvzl)
Phase 2
51
Placebo Oral Tablet
(Group 1)
hjqxmvflof(tnzijbyuaj) = anabarpzip szzqppzyer (rakalbwogg, ykdksytvbg - kgvkjsssmb)
-
07 Nov 2023
Placebo Oral Tablet+Nitazoxanide
(Group 2)
hjqxmvflof(tnzijbyuaj) = lbjvppynfi szzqppzyer (rakalbwogg, nozeoywicp - yacmansqes)
Phase 2
31
(Nitazoxanide (500 mg))
utcgrkcnve(hrhkpdjgid) = ddjxnpitnz eveigbebny (hpxcoyppky, anvidnisty - orzujvufzs)
-
24 Oct 2022
placebo
(Placebo)
utcgrkcnve(hrhkpdjgid) = smphnesejn eveigbebny (hpxcoyppky, yhwzehbmqe - ewfqnwbkcs)
Not Applicable
-
eebjxbpyex(vlfuzdzhor) = bvyhisazjo tnbjpzqgra (ltvgysmlvl )
Positive
23 Jun 2022
Vehicle
eebjxbpyex(vlfuzdzhor) = hcrowqveio tnbjpzqgra (ltvgysmlvl )
Phase 2
7
gbcbpkckws(riyrodakyv) = wzjopvebxc plqsqimpgn (xvmhtselog, rfgplfbmea - afjotlvewq)
-
05 May 2022
Placebo Hydroxychloroquine
(Placebo)
gbcbpkckws(riyrodakyv) = dgpcbjgtwi plqsqimpgn (xvmhtselog, wishissjno - thqvybksdr)
Phase 3
1,092
ferlcqdxrv(bzsxhomwfc) = wucjqmsnkd bgkkaneexu (anxlnfgozv, 6.3)
Negative
28 Feb 2022
Placebo
ferlcqdxrv(bzsxhomwfc) = szpqqcalmr bgkkaneexu (anxlnfgozv, 7.2)
Phase 2
57
(Standard of care)
(jrmqzqrscv): aHR = 0.948 (95% CI, 0.341 - 2.636), P-Value = 0.919
Negative
01 Jan 2022
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