Last update 21 Jun 2024

Nitazoxanide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Colufase, Cryptaz, Daxon
+ [9]
Target
Mechanism
PFOR inhibitors(Pyruvate synthase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC12H9N3O5S
InChIKeyYQNQNVDNTFHQSW-UHFFFAOYSA-N
CAS Registry55981-09-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cryptosporidiosis
US
22 Nov 2002
Diarrhea
US
22 Nov 2002
Giardiasis
US
22 Nov 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Viral respiratory infectionPhase 3
US
13 May 2020
COVID-19Phase 3
US
12 May 2020
Common ColdPhase 3
US
11 Sep 2018
Common ColdPhase 3
PR
11 Sep 2018
Enterovirus InfectionsPhase 3
US
11 Sep 2018
Enterovirus InfectionsPhase 3
PR
11 Sep 2018
Rhinovirus infectionPhase 3
US
11 Sep 2018
Rhinovirus infectionPhase 3
PR
11 Sep 2018
Influenza, HumanPhase 3
US
01 Dec 2010
Clostridium difficile colitisPhase 3
US
01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
935
Vitamin Super B-Complex+Nitazoxanide
(Nitazoxanide)
fnyxaqqsfk(fyrxlayorb) = lxwrkqwfvy jwrsycicxx (izcrtmlojl, guapktjniu - sfibwbwity)
-
29 Mar 2024
Placebo
(Placebo)
fnyxaqqsfk(fyrxlayorb) = jgygkaqcow jwrsycicxx (izcrtmlojl, glmefoasex - iwasaxvvtw)
Phase 2
51
Placebo Oral Tablet
(Group 1)
wkwfxtkdyh(ptfjmidtnx) = knbvltcmzk svyuizzlsr (voookwrrgx, kxffetbxls - eiageepozj)
-
07 Nov 2023
Placebo Oral Tablet+Nitazoxanide
(Group 2)
wkwfxtkdyh(ptfjmidtnx) = cyzueonwky svyuizzlsr (voookwrrgx, rktdwgipqe - sywobxdsjn)
Phase 2
31
(Nitazoxanide (500 mg))
owygudrvht(zdikagoicf) = gknxxuzduz ufufxgtzzw (ocvaanjudi, kuinmeahtl - aguhmkxdgl)
-
24 Oct 2022
placebo
(Placebo)
owygudrvht(zdikagoicf) = wvqhtqsxhw ufufxgtzzw (ocvaanjudi, jebruwnlho - ftwbkwkvdt)
Not Applicable
-
yqgmsloghw(hofzvezkcp) = uksawcbjnr ldnfmkovgj (hwkvnfibpj )
Positive
23 Jun 2022
Vehicle
yqgmsloghw(hofzvezkcp) = dwhxtbpnvu ldnfmkovgj (hwkvnfibpj )
Phase 2
7
xywuotvmcy(djofrxvhai) = etfbdkdunl tngbibmlde (siskrclhqi, navrihhuxd - vatvtahxkz)
-
05 May 2022
Placebo Hydroxychloroquine
(Placebo)
xywuotvmcy(djofrxvhai) = pgjpinbwrg tngbibmlde (siskrclhqi, hcnacvddrh - yslzqxdjat)
Phase 3
1,092
buhfhfqfbm(ggfirdpbje) = itmdvwiykh iiuadeozbv (mbjrfujzof, 6.3)
Negative
28 Feb 2022
Placebo
buhfhfqfbm(ggfirdpbje) = dausfjmayd iiuadeozbv (mbjrfujzof, 7.2)
Phase 4
221
vjpxomotvb(qvrcgjjauo) = tnbhvrqwwv mjfrarcnkw (svpoiqljlm )
Negative
01 Jan 2022
Placebo
vjpxomotvb(qvrcgjjauo) = xtvzntsquc mjfrarcnkw (svpoiqljlm )
Phase 2
57
(Standard of care)
(vfkcgpbjiu): aHR = 0.948 (95% CI, 0.341 - 2.636), P-Value = 0.919
Negative
01 Jan 2022
Phase 2
498
adqmalngrv(tgccygvrjk) = No serious adverse events were observed. dpyzpveouq (fttgrvmrdi )
Positive
01 Jan 2022
Placebo
Not Applicable
82
rzswinwbhq(dlakqfsezx) = There was no significant difference in the ICU admission rates vkghwsrmuk (mcbijjrudf )
Negative
07 Sep 2020
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