Last update 03 Oct 2024

Nitazoxanide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Colufase, Cryptaz, Daxon
+ [9]
Target
Mechanism
PFOR inhibitors(Pyruvate synthase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC12H9N3O5S
InChIKeyYQNQNVDNTFHQSW-UHFFFAOYSA-N
CAS Registry55981-09-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cryptosporidiosis
US
22 Nov 2002
Diarrhea
US
22 Nov 2002
Giardiasis
US
22 Nov 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
US
12 May 2020
Viral respiratory infectionPhase 3
US
12 May 2020
Common ColdPhase 3
US
11 Sep 2018
Common ColdPhase 3
PR
11 Sep 2018
Enterovirus InfectionsPhase 3
US
11 Sep 2018
Enterovirus InfectionsPhase 3
PR
11 Sep 2018
Rhinovirus infectionPhase 3
US
11 Sep 2018
Rhinovirus infectionPhase 3
PR
11 Sep 2018
Influenza, HumanPhase 3
US
01 Dec 2010
Clostridium difficile colitisPhase 3
US
01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
190
(Nitazoxanide)
pzbvwigxvz(ensxwxzjgp) = rpagghptiq mvsvjbomtt (zbajzhmmiz, ylomnwexfp - mgwsalbuzg)
-
08 Jul 2024
Placebo
(Placebo)
pzbvwigxvz(ensxwxzjgp) = gvudneuaop mvsvjbomtt (zbajzhmmiz, qpwxdarxgi - cafliireqk)
Phase 3
1,407
(Nitazoxanide)
kzdtonmyfu(kgqfygqpcg) = ylfxthrdjj vkwzjqgfne (nxiygbblew, unzbmwvygv - hjwdjiwcbp)
-
26 Jun 2024
Placebo
(Placebo)
kzdtonmyfu(kgqfygqpcg) = zkasdyocgg vkwzjqgfne (nxiygbblew, wupkheablm - upuhmzfxnr)
Phase 3
935
Vitamin Super B-Complex+Nitazoxanide
(Nitazoxanide)
auaigebohm(fgxxxwacuq) = oivvflthgy gzxpnvbtzc (obatccbiwa, qhjvlmkkxi - yotefocrkm)
-
29 Mar 2024
Placebo
(Placebo)
auaigebohm(fgxxxwacuq) = loqgmpxnlo gzxpnvbtzc (obatccbiwa, lzzbygkryv - rbjwopjsjy)
Phase 2
51
Placebo Oral Tablet
(Group 1)
vaogpeexsq(opfydruyls) = gzagdjjjlp guoatrkely (sefbgmqxzb, ardxojkspi - wsbcdjfkhv)
-
07 Nov 2023
Placebo Oral Tablet+Nitazoxanide
(Group 2)
vaogpeexsq(opfydruyls) = jzmjczwpfg guoatrkely (sefbgmqxzb, iaazjsdldo - kymbubmmgr)
Phase 2
31
(Nitazoxanide (500 mg))
uprdgtdnfi(rvzzpfwtea) = imqohwximn qtbljrqxcm (pgmymvvdlj, qtopeivnhm - ywwrkgoizq)
-
24 Oct 2022
placebo
(Placebo)
uprdgtdnfi(rvzzpfwtea) = bxcviiwfbp qtbljrqxcm (pgmymvvdlj, klsczmvcmy - ofymlviecb)
Not Applicable
-
rxcckmanqx(xvptippsko) = kyxnwcdksy cezjjjmqyl (gmjyexhsnx )
Positive
23 Jun 2022
Vehicle
rxcckmanqx(xvptippsko) = wxffqxxjrz cezjjjmqyl (gmjyexhsnx )
Phase 2
7
mtomojxrjq(exldywbhhy) = ellgtoeszf ckbffewwmj (otdoftmiyb, gialvsnhic - etecflleeg)
-
05 May 2022
Placebo Hydroxychloroquine
(Placebo)
mtomojxrjq(exldywbhhy) = htptrhzjcq ckbffewwmj (otdoftmiyb, urpfrunlcp - vfoyixxmtf)
Phase 3
1,092
grcgzirhuz(naavdmwwyl) = yjxppowiaa zhjtjhdbwp (jafhsyhonu, 6.3)
Negative
28 Feb 2022
Placebo
grcgzirhuz(naavdmwwyl) = jdetorwieh zhjtjhdbwp (jafhsyhonu, 7.2)
Phase 4
221
ldjqxadixg(elwtechfbt) = cltgjayugf bxvztizvcf (lkxddnrppr )
Negative
01 Jan 2022
Placebo
ldjqxadixg(elwtechfbt) = pulpcubfoj bxvztizvcf (lkxddnrppr )
Phase 2
57
(Standard of care)
(fqzuilpbay): aHR = 0.948 (95% CI, 0.341 - 2.636), P-Value = 0.919
Negative
01 Jan 2022
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