Synonyms CBF-AML - core binding factor acute myeloid leukemia, Core Binding Factor Acute Myeloid Leukemia, Core binding factor acute myeloid leukaemia + [4] |
Introduction Acute myeloid leukemia characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis. |
Target |
Mechanism PDGFRα inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date09 Jan 2020 |
Start Date01 Jun 2022 |
Sponsor / Collaborator |
Start Date22 Sep 2021 |
Sponsor / Collaborator- |
Start Date01 Jan 2020 |
Sponsor / Collaborator Nanfang Hospital [+4] |