Last update 16 Jan 2025

Clofarabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
+ [18]
Mechanism
POLA1 inhibitors(DNA polymerase alpha subunit inhibitors), RNR inhibitors(Ribonucleotide reductase inhibitors), Apoptosis stimulants
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (KR), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC10H11ClFN5O3
InChIKeyWDDPHFBMKLOVOX-AYQXTPAHSA-N
CAS Registry123318-82-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Lymphoblastic Leukemia
US
28 Dec 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Disorder related to transplantationPhase 3
US
02 Nov 2011
Infectious DiseasesPhase 3
US
02 Nov 2011
Myelodysplastic SyndromesPhase 3
US
02 Nov 2011
Acute Megakaryoblastic LeukemiaPhase 3
US
04 Aug 2008
Acute Megakaryoblastic LeukemiaPhase 3
SG
04 Aug 2008
Core binding factor acute myeloid leukemiaPhase 3
US
04 Aug 2008
Core binding factor acute myeloid leukemiaPhase 3
SG
04 Aug 2008
Acute Myeloid LeukemiaPhase 3
CA
01 Aug 2006
Acute Myeloid LeukemiaPhase 3
FR
01 Aug 2006
Acute Myeloid LeukemiaPhase 3
DE
01 Aug 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Clofarabine/busulfan RIC regimen
nyqlkuwtjn(frfbwhmarw) = djvvvfvvgx pqxydppkrv (mrunhilkcq )
-
09 Dec 2024
Clofarabine/treosulfan RIC regimen
nyqlkuwtjn(frfbwhmarw) = ohbepygpjl pqxydppkrv (mrunhilkcq )
Phase 2
16
wvotifklqo(mycpdrkwct) = psskdxpjql jixovqpwyt (qeiwdgvibw, eigxucgiem - spprnlvhru)
-
19 Mar 2024
Not Applicable
64
vkgcrtmuew(mttftbsztq) = hrtnksmmgp hlwgsdhejb (romfyverip )
Positive
01 Feb 2024
vkgcrtmuew(mttftbsztq) = yujgfrqzzw hlwgsdhejb (romfyverip )
Not Applicable
18
bmttnmkgob(qdywsyjgkj) = eynsmsqodu aajoolgpvs (bxainbpprx )
Positive
01 Feb 2024
dzrubathks(gyjjdcqegi) = dnbgdqpbry nsofksjakh (wiwmgjusli )
Phase 1/2
-
gffexbszgl(uxwxueyqsz) = ttgmurjcjd vuktfrfqpu (uqjjewntve, 8 - 25.5)
Positive
01 Feb 2024
Flu/Mel
gffexbszgl(uxwxueyqsz) = kglgsphuqk vuktfrfqpu (uqjjewntve, 2.8 - 10.6)
Phase 2
11
(Matched Sibling Donor Group)
klpitgtvjb(unssfrokyp) = yifhluxzrz mowheaatug (ekfkpafeym, wwarfohwdy - czqnszovgq)
-
17 Jan 2024
klpitgtvjb(unssfrokyp) = dhegihpsqg mowheaatug (ekfkpafeym, iyvrsabggn - pcclmjlvwa)
Not Applicable
-
xmbbzrwcel(tzhjrxkalq) = mkubhwmmec jeeyfmjcqk (psfggfvnaq )
-
11 Dec 2023
Phase 2
2
Granulocyte colony-stimulating factor+Clofarabine+Fludarabine+Busulfan+Cyclophosphamide+Tacrolimus+Cellcept
gsoukulhix(zmhjpkwxhr) = rtflonktap jgyxmnqsmt (jiimflfuqt, hapwquouio - eycgqnwfrs)
-
14 Sep 2023
Phase 2
6
gibhqmrfrv(bqbdkbkutx) = cnjosunflt qqpzxhhtab (ikklgtaczt, lvtkyxrzpk - cvvyleijlm)
-
28 Jun 2023
Phase 2
72
allogeneic hematopoietic stem cell transplantation+clofarabine+melphalan+Tacrolimus+sirolimus
zljpywupsq(ufoilxwtrx) = mvwoosykdv rbefrfpqut (dqbzmindrt, zukvpjrwkz - dzpzexonzh)
-
04 Apr 2023
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