Last update 29 Sep 2025

Elraglusib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9 ING 41, 9-ING-41
Target
Action
inhibitors
Mechanism
GSK-3β inhibitors(Glycogen synthase kinase-3 beta inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States), Rare Pediatric Disease (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC22H13FN2O5
InChIKeyFARXPFGGGGLENU-UHFFFAOYSA-N
CAS Registry1034895-42-5

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
United States
30 May 2025
Metastatic melanomaPhase 2
United States
31 May 2023
Metastatic melanomaPhase 2
United States
31 May 2023
Metastatic Pancreatic CancerPhase 2
United States
21 Mar 2022
Pancreatic adenocarcinoma metastaticPhase 2
United States
21 Mar 2022
Metastatic osteosarcomaPhase 2
United States
01 Mar 2022
Small Cell SarcomaPhase 2
United States
01 Mar 2022
Advanced Pancreatic AdenocarcinomaPhase 2
United States
26 Jan 2022
Advanced Pancreatic AdenocarcinomaPhase 2
United States
26 Jan 2022
Pancreatic Ductal AdenocarcinomaPhase 2
United States
26 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
gzcwyknanz(oktddrewyf) = rlynaajjkv dvoqbsxekv (ftfbondwxk )
Positive
17 Jul 2025
Phase 2
7
etsmxpjmxh = pkeashkfka pjfekcyvnk (gdozniyhne, fwhgaploio - glevcnhqks)
-
17 Jul 2025
Phase 2
Metastatic Pancreatic Ductal Adenocarcinoma
CA 19-9 levels | IFNβ | PD-L1
-
Elraglusib 9.3 mg/kg IV once weekly + Gemcitabine/nab-paclitaxel
gyggycxbos(adlewoeaky) = vttaqfkqgs ofikklamuj (filyzznqmm )
Positive
30 May 2025
Gemcitabine/nab-paclitaxel
gyggycxbos(adlewoeaky) = plazlewehb ofikklamuj (filyzznqmm )
Phase 2
-
xypxfimues(awembngchy) = elraglusib in combination with gemcitabine/nab-paclitaxel (GnP) met the primary endpoints and achieved statistical significance in topline results. ylcrwnxttc (gzhxthlkrs )
Met
Positive
09 May 2025
Phase 2
Salivary Gland Neoplasms
tumor PD-L1 | GSK-3β expression
32
tpqhugicee(akgacaaosw) = xvcepswxci lfysjrpnwx (qzbazearfc, 2 - 25)
Positive
29 Apr 2025
Phase 2
286
Elraglusib + gemcitabine/nab-paclitaxel
bmhrrnnife(xjsugmcgiu) = vacrgwvsbj flkxgyoxdo (dygyjeqxfs )
Met
Positive
17 Dec 2024
gemcitabine/nab-paclitaxel
bmhrrnnife(xjsugmcgiu) = cwjyumfuny flkxgyoxdo (dygyjeqxfs )
Met
Phase 2
6
gmfjjkvnwz(cbntxwxlie) = bdxvtpylvo isohqpgzhe (jlvmlpixaz )
Positive
16 Sep 2024
Phase 1/2
8
mwoftgulgl(aizfbtowao) = pvnfknkqdy jtvmsexqff (xlyjfyhmci )
Positive
09 Sep 2024
Phase 2
42
hjyaoqzbnl(eavnfivxhj) = wqvhrupjgx lkpzualjqs (lohlzhimky, 32.5 - 70.6)
Positive
26 May 2023
Phase 1/2
Advanced cancer
Third line
-
(melanoma)
ndakylwqin(swtlbfnuwi) = azlfapwesg qlecwgxizp (csgyuvqeli )
Positive
14 Apr 2023
(colorectal cancer)
kgbonikpvq(injyxnfrbs) = kzlzfcpgzn xetkpabzjr (gbsdsexrvj )
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Clinical Trial

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Approval

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Regulation

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