Delving into the Latest Updates on Benoxinate Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid, 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester, Benoxinate

+ [21]

Target

SCNA

Mechanism

SCNA modulators(Sodium channel alpha subunit modulators)

Therapeutic Areas

Eye DiseasesOther Diseases

Active Indication

Excessive tearingAnesthesia

Inactive Indication-

Originator Organization

Santen Pharmaceutical Co., Ltd.

Active Organization

Santen Pharmaceutical Co., Ltd.

ROHTO NITTEN Co., Ltd.

Shenyang Oasis Pharmaceutical Co., Ltd

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (07 Jun 1966),

Anesthesia

Regulation-

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Structure

Molecular FormulaC17H29ClN2O3

InChIKeyPRGUDWLMFLCODA-UHFFFAOYSA-N

CAS Registry5987-82-6

The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step transepithelial PRK surgery.
The main research questions to answer are:
Question 1: Are topical anesthetics effective in reducing post-PRK pain?
Question 2: Are short-term topical anesthetics toxic to the cornea?
Question 3: How to prevent abuse of topical anesthetics by patients at home?
Participants were planned to undergo a bilateral single-step transepithelial PRK surgery to correct their refractive errors and received a standard post-PRK treatment regimen for both eyes. Additionally, one eye was offered a preservative-free topical anesthetic as an experimental group and the other eye was offered a preservative-free artificial tear as a control group.

Start Date30 Jan 2023

Sponsor / Collaborator

Assiut University

NCT05666362 / RecruitingNot ApplicableIIT

Hemodynamic Response Of Premature Brain To Pain During Retinopathy Of Prematurity Screening: A Randomized Controlled Trial

Study of cerebral hemodynamic changes in preterm infant and the effect of topical anesthetic eye drops ( benoxinate hydrochloride 0.4% ) on PIPP score and cerebral hemodynamic changes during fundus examination in neonates with gestational age ≤ 34 weeks or birth weight ≤ 2.000 Kg regardless their gestational age , after postnatal day 28.

Start Date20 Jan 2023

Sponsor / Collaborator

Alexandria University

NCT06461975 / CompletedPhase 3IIT

Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening

Aims: To evaluate the effects of topical Benoxinate HCL eye drops on the Premature Infant Pain Profile (PIPP) scores in infants undergoing Retinopathy of Prematurity (ROP) screening.
Methods: A randomized prospective double-masked cross-over trial was conducted on preterm infants screened for ROP at least twice. Dilated fundus examination was done in Group A infants using the tear substitute eye drops and the second using the Benoxinate HCL drops and the reversed order of drops for Group B. Video recording of the pulse oximeter monitor, the face and the body of the infant were analyzed by a single neonatology consultant for Premature Infant Pain Profile (PIPP) scoring 1 minute before, during the examination of the first eye, 1 minute and 5 minutes after the conclusion of the examination of the second eye. The sound of the ophthalmologist on the video recordings indicating the time of the lid speculum insertion, the shining of the indirect ophthalmoscope light without indentation and the scleral indentation would aid in assessing the differences of the PIPP indicators during each step of the examination.

Start Date01 Jan 2023

Sponsor / Collaborator

Alexandria University

100 Clinical Results associated with Benoxinate Hydrochloride

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100 Translational Medicine associated with Benoxinate Hydrochloride

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100 Patents (Medical) associated with Benoxinate Hydrochloride

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310

Literatures (Medical) associated with Benoxinate Hydrochloride

01 Dec 2024·INTERNATIONAL JOURNAL OF PHARMACEUTICS

Spring and parachute approach for piroxicam dissolution; its phenomenological model on the thermodynamics of irreversible processes

Article

Author: Goto, Satoru ; Tsunoda, Chihiro ; Moritake, Kota ; Tsuchida, Tomohiro ; Kataoka, Hikaru ; Fujita, Momoko

Even though the spring and parachute approach for poorly water-soluble drug candidates effectively improves their dissolution curves with eutectic mixtures, deep eutectic solvents, solid dispersion polymers, and solid solutions, we cannot consider that its enabling factor in these pharmaceutical modifications was enough to be clarified. Based on our previous study that oxybuprocaine acts as a role of parachute generator for piroxicam, the present study explored a small-molecule parachute generator and found that propranolol, a β-adrenergic-blocking drug, has a parachute effect on the supersaturated state of piroxicam. In addition, changing the concentration of tetracaine and dibucaine to 10 mM and 2.5 mM also showed a parachute effect. These parachute generators control piroxicam's dissolved state kinetically by making the supersaturated state of piroxicam a steady state. However, as the piroxicam anhydrous crystals diminished and the piroxicam monohydrate crystals grew due to Ostwald ripening, it led to attenuating the supersaturated state. This finding advances the elucidation of the mechanism of the parachute effect of polymers.

15 Jun 2024·VETERINARY RECORD

Comparing the intraocular pressure values obtained with a rebound tonometer (TONOVET Plus) and an indentation tonometer (IOPvet) in dogs with and without ocular disease

Article

Author: Michaud, Bertrand ; Lesne, Fabien

Abstract:

Background:

This study aimed to compare the intraocular pressure (IOP) values obtained from two groups of dogs using the IOPvet indentation tonometer to those obtained from the same dogs using an established rebound tonometer (TONOVET Plus).

Methods:

Tonometry was performed on 36 dogs with ocular diseases (70 eyes; group A) and 25 healthy dogs (49 eyes; group B). First, the TONOVET Plus rebound tonometer was used. Then, one drop of oxybuprocaine hydrochloride was applied to each eye, and 1 minute later, the IOP was estimated using the IOPvet.

Results:

The IOPvet was safe, well tolerated and easy to use. The instrument had a high specificity (98.5%) for identifying IOPs of 20 mmHg or less. A lack of sensitivity (67.9%) was noted when evaluating eyes with an IOP between 20 and 30 mmHg. The sensitivity (33.3%) for identifying canine eyes with an IOP of greater than 30 mmHg (n = 24) was low.

Limitations:

This study lacks manometric work, which would be hard to justify with client‐owned dogs. Quantitative numerical data were compared with qualitative values and the same investigator obtained readings using both tonometers without being masked.

Conclusions:

The IOPvet is highly sensitive for assessing normal IOPs, but underestimation of higher IOPs can lead to poor diagnostics. Digital tonometers remain the best way to assess IOP in veterinary clinics.

01 May 2024·Annals of emergency medicine

Use of Topical Anesthetics in the Management of Patients With Simple Corneal Abrasions: Consensus Guidelines From the American College of Emergency Physicians

Article

Author: Valente, Jonathan H ; Tomaszewski, Christian ; Lo, Bruce ; Milne, Ken ; Green, Steven M

The management of corneal abrasions has largely excluded dispensing topical local anesthetics for home use due to concern for corneal toxicity. We have reviewed and critically appraised the available literature evidence regarding the use of topical anesthetics in patients with simple corneal abrasions. Using sequential Delphi review, we have developed these clinical guidelines. Herein are evidentiary summaries and consensus recommendations for 8 specific relevant questions. Our key observation is that for only simple corneal abrasions, as diagnosed and treated in accordance with the full protocol described herein, it appears safe to prescribe or otherwise provide a commercial topical anesthetic (ie, proparacaine, tetracaine, oxybuprocaine) for use up to every 30 minutes as needed during the first 24 hours after presentation, as long as no more than 1.5 to 2 mL total (an expected 24-hour supply) is dispensed and any remainder is discarded after 24 hours. Importantly, although published findings suggest absent harm for short courses, more rigorous studies with a greater cumulative sample size and ophthalmologic follow-up are needed.

100 Deals associated with Benoxinate Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D01768	Benoxinate Hydrochloride	D04AB03 S01HA02	DB00892

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Excessive tearing	JP	Santen Pharmaceutical Co., Ltd.	26 Dec 1972
Anesthesia	JP	Santen Pharmaceutical Co., Ltd.	07 Jun 1966

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02528123 (CTgov)	Not Applicable	Myopia	114	Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin	chwcuvijwu(ggqblabjqc) = vbhsqlbaal kbljjxmmef (ckwenoslvg, utznmaixyw - ujnobystfy) View more	-	23 Apr 2024
EURETINA2021	Not Applicable	-	42	Oxybuprocaine Hydrochloride	vfxgxdsbue(jrotakjfkx): P-Value = 0.029 View more	Positive	01 Sep 2021
				No Oxybuprocaine Hydrochloride
ARVO2006	Not Applicable	Ophthalmologic surgical procedures	50	Tetracaine/Oxybuprocaine	hidygagkrb(dnotjvhfjh) = ftexoqdqvf zzuqmsgysr (eymlynzrwt )	Positive	01 May 2006
				Oxybuprocaine	hidygagkrb(dnotjvhfjh) = jbpgqmkjli zzuqmsgysr (eymlynzrwt )