To assess the effect of topical ofloxacin combination of topical ofloxacin and topical povidine iodine on conjuntival flora in preoperative cataract surgery patients - NIL

Start Date24 Apr 2025

Sponsor / Collaborator-

CTRI/2024/09/074346

/ Not yet recruitingNot ApplicableIIT

Evaluation of a novel bilayer film loaded with ornidazole and ofloxacin for the treatment of patients with moderate periodontitis – A randomized controlled trial - NIL

Start Date26 Sep 2024

Sponsor / Collaborator-

100 Clinical Results associated with Ofloxacin

100 Translational Medicine associated with Ofloxacin

100 Patents (Medical) associated with Ofloxacin

14,706

Literatures (Medical) associated with Ofloxacin

01 Feb 2026·COMPUTATIONAL BIOLOGY AND CHEMISTRY

Design and synthesis of tunable schiff base complexes from bis-(2-oxoindolin-3-ylidene)anthracene-9,10-dione: Integrated structural, biological, and molecular modeling insights

Article

Author: Alghamdi, Mashael A ; Al-Farraj, Eida S ; Alzahrani, Abdullah Yahya Abdullah ; Abdel-Hameed, Mohamed ; Alahmadi, Nadiyah ; Abdou, Aly ; Abu-Dief, Ahmed M ; Fathalla, Maher

Three novel compounds, each featuring a tetra-dentate ligand known as 1-((2-oxoindolin-3-ylidene)amino)-2-((2-oxoindolin-3-ylidene)amino)anthracene-9,10-dione (BIA), have been successfully synthesized. These molecules exhibit the unique characteristic of forming complexes with Cu(II), Ru(III), and VO(II) metal ions, resulting in distinct metal-organic structures.Structural characterization was performed using elemental analysis, magnetic properties measurement, FT-IR spectroscopy, and electronic spectroscopy. Moreover, the stoichiometry in solution was determined through both continuous variation and molar ratio analysis. These analyses have shown that the copper and ruthenium complexes exhibit an octahedral geometric configuration. Conversely, the vanadyl (VO) complex demonstrates a distinct square pyramidal structure.Density functional theory (DFT) computations were employed to confirm the geometrical configurations of the prepared complexes. The synthesized BIA ligand and its corresponding metal complexes were assessed for their in vitro antimicrobial. The results indicated that the RuBIA complex emerged as the most efficacious agent against both bacterial and fungal growth, outperforming established medications like Ofloxacin and Fluconazole as standard drugs with sequenceBIA < VOBIA < CuBIA  CuBIA > VOBIA complex>BIA ligand.

01 Jan 2026·TALANTA

A colorimetric DNAzyme biosensor based on G-triplex/hemin for detecting ofloxacin in food

Article

Author: Wang, Chong ; Huang, Yukun ; Xu, Chi ; Huang, Xiaojun ; Mahmood Khan, Imran ; Chen, Xianggui ; Pan, Xiaomei ; Tang, Jie ; Ran, Wenchao

Ofloxacin, a synthetic antimicrobial drug, exhibits significant therapeutic potential in combating various bacterial infections. The exploration of ofloxacin's antimicrobial properties and the unique catalytic activity of G-triplex(G3) DNAzymes demonstrate the continuous efforts to develop cutting-edge biosensors for bacterial detection. G3 outperforms G4 due to a short, easily generated and dissociated sequence, which allows G3 multimeric sequences to fold more accurately than G4 ones of equivalent length, resulting in higher activity for the formed G3/hemin. This study constructed a novel colorimetric DNAzyme biosensor based on G3/hemin for ofloxacin in food. Aptamer-functionalized Fe₃O₄ magnetic nanoparticles acted as magnetic separation and detection probes, while G3/hemin served as DNAzyme. Under the optimum condition, the presence of ofloxacin initiated the catalytic oxidation to yield a colored product to quantify the ofloxacin concentration with the linear range of 50-300 nmol/L. Under the optimized conditions, a limit of detection of 15.25 nmol/L was obtained by directly detecting the fluorescent signals, which shows obvious superiority over the previously reported methods. This method offers the advantages of simplicity, rapid detection, and high recovery rates in standardization experiments involving actual samples such as beef jerky and ham sausage, paving the way for its widespread implementation in the fields of biomedical diagnostics, environmental monitoring, and food safety.

01 Jan 2026·WATER RESEARCH

Data-driven persistence correction and environmental health prioritization of pharmaceuticals and personal care products in biological wastewater treatment processes

Article

Author: Gong, Sai ; Liu, Qiuju ; Ren, Xinkun ; Zhu, Boyang ; Wang, Jinfeng ; Yin, Ran ; Fan, Yingzheng ; Zhang, Shubo ; Huang, Yizhan

Pharmaceuticals and personal care products (PPCPs) can accumulate during biological wastewater treatment processes (BWWTPs) and are easily released into the environment, posing serious ecological risks. However, current concentration-based persistence assessments of PPCPs in BWWTPs are inaccurate due to nonlinear biotransformation-adsorption interactions. In this study, we analyzed 28 PPCPs in 768 water samples across influent, biological stages, and effluent from 154 BWWTPs in China. Unsupervised learning and variance partitioning analysis (VPA) were applied to evaluate the biotransformation-related variance share and to correct apparent persistence. An environmental health prioritization index (EHPi) was subsequently developed to rank PPCPs for control based on corrected removal rates. Detection frequencies of 21 PPCPs in effluent exceeded those in influent, and 20 PPCPs exhibited negative removal, with oxic-stage removal significantly lower than that in the anoxic and anaerobic stages, indicating widespread desorption and deconjugation. VPA showed that reversible adsorption accounted for an average of 60.33 % of the variance, suggesting that prioritization based on apparent removal rates was biased. Molecular descriptors and fingerprints further demonstrated that structural features have a strong influence on PPCP biotransformation. The EHPi was created based on the adjusted removal rate weighted by the biotransformation-related variance share. The results showed that the priorities of roxithromycin, ketoprofen, clarithromycin, tetracycline, and sulfadimethoxypyrimidine were incorrectly assessed. Finally, diclofenac, ciprofloxacin, ofloxacin, norfloxacin, roxithromycin, amoxicillin, and ketoprofen were identified as high-priority PPCPs. This framework enables persistence correction and informed prioritization for environmental risk management and wastewater treatment for PPCPs.

News (Medical) associated with Ofloxacin

29 Nov 2024

·pharma.economictimes.indiatimes.com

CDSCO monthly review finds 56 drugs as substandard, flags 3 as spurious

New Delhi: As part of its monthly review undertaken to check and enforce the quality standards in the consumer drug market, the Central Drugs Standard Control Organization ( CDSCO ) has identified 56 drug samples as ‘Not of Standard Quality’ (NSQ) and 3 as ‘spurious.’ The drugs and formulations which have been classified as spurious picked by Bihar Drugs Control Authority include Pantoprazole Gastro-resistant and Domeperiodone Prolong Released Capsules IP ( PAN-D); Cefixime Tablets IP (TAXIM-O 200); and Rosuvastatin Tablets IP (Rosuvas 10). As per the CDSCO notification, each of these drugs were manufactured in 2023 and the central drugs regulator is still investigating the manufacturer of the above-mentioned spurious drugs . The list of drugs and formulations which have been identified as NSQ includes Trypsin & Chymotrypsin Tablets manufactured by Cachet Pharmaceuticals Private Limited; Diclofenac Sodium, Paracetamol & Chlorzoxazone Tablets by MODERN LABORATORIES; Liposomal Amphotericinn B Injection 50mg by UNITED BIOTECH (P) LIMITED; Ornidazole & Ofloxacin Tablets IP by Hindustan Antibiotics Ltd; Amlodipine and Perindopril Tablets by Intas Pharmaceuticals Ltd.; Natamycin Ophthalmic Suspension by Primus Pharmaceuticals, among 50 others. All samples notified under the NSQ list for the month of October (released in November) were manufactured between 2022 and 2024, and CDSCO has identified the manufacturers of each of the listed products. Meanwhile, during the same period the State Drugs Testing Laboratories across the country have identified 34 Drugs Samples as Not of Standard Quality (NSQ). According to CDSCO, a drug shall be deemed spurious if it is manufactured under a name belonging to another drug; or if it is an imitation of, or a substitute for, another drug; or resembles another drug in a manner likely to deceive or bears upon its label or container the name of another drug, among other provisions defined under Section 17-B of the Drugs and Cosmetics Act, 1940. Whereas those drugs that fail to meet the quality standards or specifications are notified as NSQ, a term defined under Section 16(1)(a) of the Drugs and Cosmetics Act, 1940. By Online Bureau ,

NDADrug Approval

23 Aug 2024

·pharma.economictimes.indiatimes.com

Govt bans 156 medicines including antibiotics, painkillers, multivitamins: Here is the full list

New Delhi: In a significant move aimed at safeguarding public health, the Indian government has banned 156 fixed-dose combination (FDC) drugs, including a variety of antibiotics, painkillers, multivitamins, and medications for treating fever and hypertension. This decision marks the largest crackdown on FDCs since 2016, when 344 such drugs were prohibited. The Union Ministry of Health and Family Welfare issued a gazette notification on Thursday, officially prohibiting the manufacture, sale, and distribution of the banned FDCs. The ban was based on the recommendations of an expert panel that reviewed a total of 324 FDCs. Impact on Pharmaceutical Industry The banned FDCs include popular combinations such as mefenamic acid and paracetamol injections, commonly used for pain relief and fever, and omeprazole magnesium with dicyclomine HCl, used to treat abdominal pain. The ban is expected to impact major pharmaceutical companies, including Sun Pharmaceuticals, Cipla, Dr. Reddy's Laboratories, Torrent Pharmaceuticals, and Alkem Laboratories. Fixed Dose Combinations Drug Banned List Here is a table listing all 156 banned Fixed Dose Combinations (FDCs) SN Fixed Dose Combination (FDC) 1 Amylase + Protease + Glucoamylase + Pectinase + Alpha Galactosidase + Lactase + Beta-Gluconase + Cellulase + Lipase + Bromelain + Xylanase + Hemicellulase + Malt diastase + Invertase + Papain 2 Antimony Potassium Tartrate + Dried Ferrous Sulphate 3 Benfotiamine + Silymarin + L-Ornithine L-aspartate + Sodium Selenite + Folic acid + Pyridoxine hydrochloride 4 Bismuth Ammonium Citrate + Papain 5 Cyproheptadine HCl + Thiamine HCl + Riboflavine + Pyridoxine HCl + Niacinamide 6 Cyproheptadine Hydrochloride + Tricholine Citrate + Thiamine Hydrochloride + Riboflavine + Pyridoxine Hydrochloride 7 Rabeprazole Sodium (As enteric coated tablet) + Clidinium Bromide + Dicyclomine HCl + Chlordiazepoxide 8 Fungal Diastase + Papain + Nux vomica Tincture + Cardamom Tincture + Casein Hydrolysed + Alcohol 9 Mefenamic Acid + Paracetamol Injection 10 Omeprazole Magnesium + Dicyclomine HCl 11 S-adenosyl methionine + Metadoxine + Ursodeoxycholicacid BP + L-Methylfolate Calcium eq. to L- Methylfolate + Choline bitartratee + Silymarin + L-ornithine Laspartate + Inositol + Taurine 12 Silymarin + Thiamine Mononitrate + Riboflavin + Pyridoxine HCl + Niacinamide + Calcium pantothenate + Vitamin B12 13 Silymarin + Pyridoxine HCl + Cyanocobalamin + Niacinamide + Folic Acid 14 Silymarin + Vitamin B6 + Vitamin B12 + Niacinamide + Folic acid + Tricholine Citrate 15 Sodium Citrate + Citric Acid Monohydrate Flavored with Cardamom Oil, Caraway Oil, Cinnamon Oil, Clove Oil, Ginger Oil + Alcohol 16 Sucralfate + Acelofenac 17 Sucralfate + Domperidone + Dimethicone 18 Sucralfate + Domperidone 19 Tincture Ipecacuanha + Tincture Urgenia + Camphorated Opium Tincture + Aromatic Spirit of Ammonia + Chloroform + Alcohol 20 Ursodeoxycholic Acid + Metformin HCl 21 Weak Ginger tincture + Aromatic Spirit of Ammonia + Peppermint Spirit + Chloroform + Sodium Bicarbonate + Compound Cardamom + Alcohol 22 Sucralfate + Pantoprazole Sodium + Zinc Gluconate + Light Magnesium Carbonate 23 Aloe + Vitamin E Soap 24 Povidone Iodine+ Metronidazole + Aloe 25 Azelaic acid + Tea Tree Oil + Salicylic acid + Allantoin + Zinc oxide + Aloe vera + Jojoba oil + Vitamin E + Soap noodles 26 Azithromycin + Adapalene 27 Calamine + Aloes + Allantoin 28 Calamine + Diphenhydramine Hydrochloride + Aloe + Glycerine + Camphor 29 Chlorphenesin + Zinc oxide + Starch 30 Clindamycin Phosphate + Zinc acetate 31 Gamma Benzene Hexachloride + Benzocaine 32 Glucosamine hydrochloride + Diacerein + Menthol + Camphor + Capsaicin 33 Hydroxyquinone 2.0%w/w + Octyl Methoxycinnamate 5.0% w/w + Oxybenzone 30 % w/w 34 Ketoconazole +Zinc Pyrithione +D-Panthenol +Tea Tree Oil +Aloes 35 Ketoconazole +Aloe vera+ Vitamin A Acetate 36 Ketoconazole +Aloes + ZPTO 37 Kojic Acid +Arbutin +Octinoxate +Vitamin E + Mulberry 38 Lornoxicam +capsaicin +menthol+ camphor 39 Lornoxicam + Thiocolchicoside +Oleum Lini +Menthol + Methyl salicylate 40 Menthol + Aloe vera Topical Spray 41 Menthol +Lignocaine HCl +Aloe vera gel +Clotrimazole +Diphenhydramine 42 Miconazole nitrate + Gentamicin + Fluocinolone Acetonide +Zinc Sulphate 43 Miconazole +Tinidazole 44 Minoxidil +Aminexil+ Alcohol 45 Minoxidil +Azelaic acid + saw palmetto 46 Minoxidil +Aminexil 47 Pine Bark extract+ Kojic acid +Sodium Ascorbyl Phosphate 48 Povidone Iodine +Tinidazole +Zinc sulphate 49 Povidone Iodine + Ornidazole + Dexpanthenol 50 Salicyclic acid +Aloe vera+ Allantoin +D-Panthenol 51 Silver sulphadiazine +Chlorhexidine Gluconate solution +Allantoin + Aloe vera gel +Vitamin E acetate 52 Sodium salicylate + Zinc gluconate + Pyridoxine HCl 53 Tetracycline + Colistin Sulphate 54 Clomiphene +Ubidecarenone 55 Combikit of Clomiphene Citrate + Estradiol Valerate 56 Flavoxate HCl +Ofloxacin 57 Clomiphene Citrate +N-Acetylcysteine 58 Primerose Oil +Cod liver oil 59 Sildenafil Citrate +Papaverine +L-Arginine 60 Tranexamic acid +Mefenamic acid + Vitamin K1 61 Divalproex Sodium +Oxcarbazepine 62 Divalproex Sodium + Levetiracitam 63 Ergotamine tartrate +Caffeine + Paracetamol +Prochlorperazine maleate 64 Piracetam + Ginkgo biloba extracts + Vinpocetin 65 Ginkgo biloba + methylcobalamin 66 Ginkgo biloba + methylcobalamin + Alpha lipoic acid +Pyridoxine HCl 67 Ginseng Extract +Dried extract of Ginkgo Biloba 68 Meclizine HCl+ Paracetamol + Caffeine 69 Nicergoline + Vinpocetine 70 Gamma Linolenic Acid + Methylcobalamin 71 Beclomethasone Dipropionate + Neomycin Sulphate + Clotrimazole + Lignocaine HCl 72 Boric acid+ Phenylephrine HCl + Naphazoline Nitrate + Menthol + Camphor 73 Naphazoline HCl + Chlorpheniramine Maleate + Zinc Sulphate + Hydroxy Propyl Methyl Cellulose 74 Chlorpheniramine Maleate + Naphazoline HCl + Zinc Sulphate + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 75 Chlorpheniramine Maleate + Naphazoline HCl + Hydroxy Propyl Methyl Cellulose 76 Chlorpheniramine Maleate + Sodium Chloride + Boric Acid + Tetrahydrozoline HCl 77 Chlorpheniramine Maleate + Phenylephrine HCl + Antipyrine 78 Ketorolac Tromethamine + Chlorpheniramine Maleate + Phenylephrine HCl + Hydroxy Propyl Methyl Cellulose 79 Ketorolac Tromethamine + Flurometholone 80 Naphazoline HCl + Zinc Sulphate + Boric Acid + Sodium Chloride+ Chlorpheniramine Maleate 81 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Boric Acid + Borax + Menthol + Camphor 82 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Chlorpheniramine Maleate SN Fixed Dose Combination (FDC) 83 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Menthol + Camphor 84 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 85 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Methylparaben 86 Methenamine + Sodium Benzoate + Benzyl Alcohol 87 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 88 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate + Caffeine 89 Propoxyphene + Chlorpheniramine Maleate 90 Propoxyphene + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 91 Propoxyphene + Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride 92 Sodium Benzoate + Sodium Citrate + Citric Acid 93 Vitamin A Palmitate + Vitamin C + Vitamin E + Vitamin B6 + Vitamin B12 94 Vitamin A Palmitate + Vitamin C + Vitamin E + Niacinamide 95 Vitamin B6 + Vitamin B12 + Vitamin C 96 Vitamin B6 + Vitamin B12 + Niacinamide 97 Vitamin B12 + Vitamin B6 + Vitamin C + Folic Acid 98 Vitamin B12 + Vitamin B6 + Niacinamide + Folic Acid 99 Vitamin C + Vitamin E + Vitamin A + Niacinamide 100 Vitamin D + Calcium + Magnesium 101 Vitamin D + Calcium + Magnesium + Zinc 102 Calcium + Vitamin D + Vitamin K 103 Calcium + Vitamin D + Magnesium + Zinc 104 Calcium + Vitamin D + Vitamin K + Magnesium 105 Calcium + Vitamin D + Vitamin K + Magnesium + Zinc 106 Vitamin E + Vitamin A + Vitamin C + Niacinamide 107 Vitamin E + Vitamin A + Vitamin C + Folic Acid 108 Vitamin E + Vitamin A + Vitamin C + Biotin 109 Vitamin E + Vitamin A + Vitamin C + Vitamin B12 110 Vitamin E + Vitamin C + Folic Acid 111 Vitamin E + Vitamin C + Biotin 112 Vitamin E + Vitamin C + Vitamin B12 113 Vitamin E + Vitamin C + Zinc 114 Calcium + Vitamin D + Omega-3 Fatty Acids 115 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K 116 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Magnesium 117 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Zinc 118 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene 119 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene + Zinc 120 Vitamin C + Vitamin E + Beta-Carotene 121 Vitamin C + Vitamin E + Beta-Carotene + Zinc 122 Vitamin C + Vitamin E + Selenium 123 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids 124 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Magnesium 125 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Zinc 126 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Biotin 127 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 128 Vitamin E + Vitamin A + Vitamin C + Zinc 129 Vitamin E + Vitamin A + Vitamin C + Selenium 130 Vitamin E + Vitamin A + Vitamin C + Biotin 131 Vitamin E + Vitamin A + Vitamin C + Folic Acid + Niacinamide 132 Vitamin E + Vitamin C + Beta-Carotene + Zinc 133 Vitamin C + Vitamin E + Biotin + Folic Acid 134 Vitamin C + Vitamin E + Beta-Carotene + Folic Acid 135 Vitamin C + Vitamin E + Beta-Carotene + Selenium 136 Vitamin E + Vitamin C + Beta-Carotene + Biotin 137 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Biotin 138 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 139 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B12 140 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B6 141 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Folate 142 Calcium + Vitamin D + Magnesium + Vitamin K + Omega-3 Fatty Acids 143 Calcium + Vitamin D + Magnesium + Vitamin K + Biotin 144 Calcium + Vitamin D + Magnesium + Vitamin K + Selenium 145 Calcium + Vitamin D + Magnesium + Vitamin K + Vitamin B12 146 Calcium + Vitamin D + Magnesium + Vitamin K + Folate 147 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B6 148 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B12 149 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Folic Acid 150 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Biotin 151 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Selenium 152 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids 153 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Zinc 154 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Biotin 155 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Selenium 156 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Vitamin B12

Drug Approval

15 Apr 2024

·www.pharmaindustrial-india.com

Caplin Steriles Receives USFDA Approval for Generic Ofloxacin Ophthalmic Solution

Caplin Steriles Limited, a subsidiary of Caplin Point Laboratories Limited, has achieved a milestone with the final approval from the United States Food and Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) Ofloxacin Ophthalmic Solution USP 0.3 percent (eye drops). This approval marks the introduction of a generic therapeutic equivalent version of OCUFLOX Ophthalmic Solution by Allergan Inc. Ofloxacin Ophthalmic Solution USP 0.3 percent is targeted for the treatment of eye infections, specifically those arising from conjunctivitis and corneal ulcers. Its approval opens avenues for patients seeking affordable yet effective solutions for these conditions. Data from IQVIATM (IMS Health) indicates that Ofloxacin Ophthalmic Solution USP 0.3 percent generated approximately USD 52 million in sales within the United States for the 12-month period ending December 2023. With this approval, Caplin Steriles Limited strengthens its position in the pharmaceutical industry by expanding its portfolio of high-quality generic medications. The availability of generic Ofloxacin Ophthalmic Solution USP 0.3 percent offers healthcare providers and patients access to a cost-effective treatment option without compromising on quality.

Drug Approval

100 Deals associated with Ofloxacin

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KEGG	Wiki	ATC	Drug Bank
D00453	Ofloxacin	S01AE01 S02AA16 J01MA01	DB01165

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Paratyphoid Fever	Japan	Alfresa Pharma Corp.	28 Aug 2000
Typhoid Fever	Japan	Alfresa Pharma Corp.	28 Aug 2000
Infectious Diseases	United States	Daiichi Pharmaceutical Co., Ltd.	16 Dec 1997
Leprosy	Japan	Alfresa Pharma Corp.	29 Aug 1996
Chlamydia trachomatis infection	Japan	Alfresa Pharma Corp.	24 Mar 1991
Corneal Ulcer	United States	Janssen Pharmaceuticals, Inc.	28 Dec 1990
Trachoma	Japan	Santen Pharmaceutical Co., Ltd.	01 Jun 1989
Pericoronitis	Japan	Alfresa Pharma Corp.	22 Feb 1988
Periodontitis	Japan	Alfresa Pharma Corp.	22 Feb 1988
Pharyngolaryngitis	Japan	Alfresa Pharma Corp.	22 Feb 1988
Secondary infection	Japan	Alfresa Pharma Corp.	22 Feb 1988
Sinusitis	Japan	Alfresa Pharma Corp.	22 Feb 1988
Tonsillitis	Japan	Alfresa Pharma Corp.	22 Feb 1988
Blepharitis	Japan	Santen Pharmaceutical Co., Ltd.	30 Jun 1987
Conjunctivitis	Japan	Santen Pharmaceutical Co., Ltd.	30 Jun 1987
Dacryocystitis	Japan	Santen Pharmaceutical Co., Ltd.	30 Jun 1987
Hordeolum	Japan	Santen Pharmaceutical Co., Ltd.	30 Jun 1987
Keratitis	Japan	Santen Pharmaceutical Co., Ltd.	30 Jun 1987
Adnexitis	Japan	Alfresa Pharma Corp.	29 Aug 1986
Uterine Cervicitis	Japan	Alfresa Pharma Corp.	29 Aug 1986

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Acute otitis media	Phase 3	-	Daiichi Sankyo Co., Ltd.	01 Nov 2002

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02528123 (CTgov)	Not Applicable	Myopia	114	Small incision lenticule extraction+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+Tobramycin and dexamethasone+Ofloxacin	zvnogyubmv(tbqkgwivxs) = nzqsqmhprj xollxsycjj (ynbyyihdjr, 0.48) View more	-	23 Apr 2024
NCT02373137 (DETECT, CTgov)	Phase 4	Corneal Diseases \| Keratoplasty rejection	38	DMEK+Prednisolone+Tropicamide+Phenylephrine+Ofloxacin (DMEK)	ltxzuisund(eeizlyggzc) = kodcfezmbw cyiwgobacq (rbklfzqxlp, 0.11) View more	-	02 Jul 2019
				DSAEK+Prednisolone+Tropicamide+Phenylephrine+Ofloxacin (DSAEK)	alzxjswymm(zefspcbsgl) = vrnoqtmpvu zuzqoxvend (xqflidgulj, 0.136) View more
ISRCTN11871179 (Pubmed \| BMC Infect Dis)	Not Applicable	Brucellosis	-	Ofloxacin plus rifampicin	xyslfbvphe(nwkttaxcye) = vouuypecge oaqzybcsmx (otcfmvfwbq, 48 - 216)	-	23 Jun 2004
				Doxycycline plus rifampicin	xyslfbvphe(nwkttaxcye) = zpignpyxmv oaqzybcsmx (otcfmvfwbq, 48 - 262)

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