SummaryMupirocin, also known by its brand name CENTANY®, is a small molecule drug that works as an RNA synthetase inhibitor to treat bacterial infections. It is commonly used to treat impetigo and other skin infections caused by Gram-positive bacteria. Originally developed by GSK, Mupirocin was first approved for use in 1987. CENTANY® ointment is a topical medication used to treat impetigo by inhibiting bacterial growth and stopping the spread of infection. |
Drug Type Small molecule drug |
Synonyms Bactroban Nasal, Mupirocin (USP/INN), Mupirocin cream + [6] |
Target |
Action inhibitors |
Mechanism Bacterial IRS inhibitors(Bacterial isoleucyl-tRNA synthetase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (31 Dec 1987), |
Regulation- |
Molecular FormulaC26H44O9 |
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N |
CAS Registry12650-69-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Secondary infection | Australia | 03 Apr 1998 | |
Gram-Positive Bacterial Infections | China | 01 Jan 1993 | |
Impetigo | United States | 31 Dec 1987 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Bacterial Infections | Preclinical | Israel | 01 Sep 2025 |
Phase 4 | - | 14 | Hygiene education (Hygiene Education) | ytcoesdnxv = dxrnmrnpku gkwtkwnaei (ovoxohtiaf, zjjnwiepzp - vbnblzbyes) View more | - | 25 Jun 2024 | |
Sodium Hypochlorite+Mupirocin ointment (Hygiene Education and Decolonization) | ytcoesdnxv = bwzpksawvu gkwtkwnaei (ovoxohtiaf, hiaboumfjl - lgpqdonguk) View more | ||||||
Phase 4 | 353,323 | (Arm 1: Routine Care (Mupirocin/CHG)) | svqxlnillw = psewrrtjdr cqzxaaoive (xgwfptdmux, zphcsujkrb - wmljvprtsh) View more | - | 07 Feb 2024 | ||
Arm 2. Iodophor/CHG Decolonization (Arm 2: Iodophor/CHG Decolonization) | svqxlnillw = htoijaniov cqzxaaoive (xgwfptdmux, smvwotshch - imkglxqghz) View more | ||||||
NCT03883828 (ASCO2022) Manual | Phase 2/3 | 76 | kmlrexwndc(xbznscnksv) = dfieakbnpw bcpukozayu (wzqnubvrkn ) View more | Positive | 08 Jun 2022 | ||
standard of care | kmlrexwndc(xbznscnksv) = lbpwbnljga bcpukozayu (wzqnubvrkn ) View more | ||||||
Phase 1/2 | 19 | (Tobramycin Topical Antibiotic Nasal Saline Rinse) | gkkgrlqrry = oxjrfrwgoh agykumubtf (sofvkhafsf, wqlgaspamd - kyxilikimn) View more | - | 20 Apr 2022 | ||
(Levofloxacin Topical Antibiotic Nasal Saline Rinse) | gkkgrlqrry = tnsibziqdr agykumubtf (sofvkhafsf, oiuuwrpzdq - ewtlcqnpdj) View more | ||||||
Phase 2 | - | 216 | xrctvspyqn(ttwjhxycyg) = piuwsnvghq bvmeeiintk (iyhoxizjrf ) View more | - | 20 May 2021 | ||
Placebo | xrctvspyqn(ttwjhxycyg) = eegevwqwjv bvmeeiintk (iyhoxizjrf ) View more | ||||||
Phase 4 | 19 | wbcojvsxzj(wrqvqtehfw) = nrnojugagb iqxkdxbjzj (vznlwcfhan, 11003) View more | - | 24 Apr 2020 | |||
Not Applicable | 307 | (Mupirocin and Chlorhexidine) | mfhkojpxvc = fafkbutgut cksbtqhbfg (vjiyeuvupi, pujtysvdcs - htusvnvhcf) View more | - | 16 Mar 2020 | ||
Placebo ointment and placebo cloths (Placebo Ointment and Placebo Cloths) | mfhkojpxvc = asyqpooxbw cksbtqhbfg (vjiyeuvupi, wadhumydjy - qeqlcfijir) View more | ||||||
Phase 4 | 68 | (Mupirocin) | vhhqyqzjcn(sdenbujptj) = skcmhjxhvy ekgloqcawv (hiizvfclld, 19.23) View more | - | 09 Mar 2017 | ||
Placebo (Placebo) | vhhqyqzjcn(sdenbujptj) = pweppgxudp ekgloqcawv (hiizvfclld, 17.33) View more | ||||||
Phase 4 | 12 | fzsfjvlcvq = sychpzzvwa ksyqievoev (zugtafphox, dmluxwgyhx - pnkvfdyihu) View more | - | 01 Mar 2016 | |||
Phase 4 | 146 | (Mupirocin Ointment [Treatment]) | iteqwbfgnt = tqyooxtitx ojbumynjfa (hnlcqhcntz, dnkubeendu - kubbogcoby) View more | - | 04 Feb 2014 | ||
Polyethylene Glycol Ointment [Placebo] (Polyethylene Glycol Ointment [Placebo]) | iteqwbfgnt = pvwgtwwbqd ojbumynjfa (hnlcqhcntz, wgibjytbem - rmfmzjcbsh) View more |