Last update 18 Sep 2025

Mupirocin

Overview

Basic Info

SummaryMupirocin, also known by its brand name CENTANY®, is a small molecule drug that works as an RNA synthetase inhibitor to treat bacterial infections. It is commonly used to treat impetigo and other skin infections caused by Gram-positive bacteria. Originally developed by GSK, Mupirocin was first approved for use in 1987. CENTANY® ointment is a topical medication used to treat impetigo by inhibiting bacterial growth and stopping the spread of infection.
Drug Type
Small molecule drug
Synonyms
Bactroban Nasal, Mupirocin (USP/INN), Mupirocin cream
+ [6]
Action
inhibitors
Mechanism
Bacterial IRS inhibitors(Bacterial isoleucyl-tRNA synthetase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1987),
Regulation-
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Structure/Sequence

Molecular FormulaC26H44O9
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N
CAS Registry12650-69-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Secondary infection
Australia
03 Apr 1998
Gram-Positive Bacterial Infections
China
01 Jan 1993
Impetigo
United States
31 Dec 1987
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bacterial InfectionsPreclinical
Israel
01 Sep 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
14
Hygiene education
(Hygiene Education)
ytcoesdnxv = dxrnmrnpku gkwtkwnaei (ovoxohtiaf, zjjnwiepzp - vbnblzbyes)
-
25 Jun 2024
Sodium Hypochlorite+Mupirocin ointment
(Hygiene Education and Decolonization)
ytcoesdnxv = bwzpksawvu gkwtkwnaei (ovoxohtiaf, hiaboumfjl - lgpqdonguk)
Phase 4
353,323
(Arm 1: Routine Care (Mupirocin/CHG))
svqxlnillw = psewrrtjdr cqzxaaoive (xgwfptdmux, zphcsujkrb - wmljvprtsh)
-
07 Feb 2024
Arm 2. Iodophor/CHG Decolonization
(Arm 2: Iodophor/CHG Decolonization)
svqxlnillw = htoijaniov cqzxaaoive (xgwfptdmux, smvwotshch - imkglxqghz)
Phase 2/3
76
kmlrexwndc(xbznscnksv) = dfieakbnpw bcpukozayu (wzqnubvrkn )
Positive
08 Jun 2022
standard of care
kmlrexwndc(xbznscnksv) = lbpwbnljga bcpukozayu (wzqnubvrkn )
Phase 1/2
19
(Tobramycin Topical Antibiotic Nasal Saline Rinse)
gkkgrlqrry = oxjrfrwgoh agykumubtf (sofvkhafsf, wqlgaspamd - kyxilikimn)
-
20 Apr 2022
(Levofloxacin Topical Antibiotic Nasal Saline Rinse)
gkkgrlqrry = tnsibziqdr agykumubtf (sofvkhafsf, oiuuwrpzdq - ewtlcqnpdj)
Phase 2
-
216
xrctvspyqn(ttwjhxycyg) = piuwsnvghq bvmeeiintk (iyhoxizjrf )
-
20 May 2021
Placebo
xrctvspyqn(ttwjhxycyg) = eegevwqwjv bvmeeiintk (iyhoxizjrf )
Phase 4
19
wbcojvsxzj(wrqvqtehfw) = nrnojugagb iqxkdxbjzj (vznlwcfhan, 11003)
-
24 Apr 2020
Not Applicable
307
(Mupirocin and Chlorhexidine)
mfhkojpxvc = fafkbutgut cksbtqhbfg (vjiyeuvupi, pujtysvdcs - htusvnvhcf)
-
16 Mar 2020
Placebo ointment and placebo cloths
(Placebo Ointment and Placebo Cloths)
mfhkojpxvc = asyqpooxbw cksbtqhbfg (vjiyeuvupi, wadhumydjy - qeqlcfijir)
Phase 4
68
(Mupirocin)
vhhqyqzjcn(sdenbujptj) = skcmhjxhvy ekgloqcawv (hiizvfclld, 19.23)
-
09 Mar 2017
Placebo
(Placebo)
vhhqyqzjcn(sdenbujptj) = pweppgxudp ekgloqcawv (hiizvfclld, 17.33)
Phase 4
12
fzsfjvlcvq = sychpzzvwa ksyqievoev (zugtafphox, dmluxwgyhx - pnkvfdyihu)
-
01 Mar 2016
Phase 4
146
(Mupirocin Ointment [Treatment])
iteqwbfgnt = tqyooxtitx ojbumynjfa (hnlcqhcntz, dnkubeendu - kubbogcoby)
-
04 Feb 2014
Polyethylene Glycol Ointment [Placebo]
(Polyethylene Glycol Ointment [Placebo])
iteqwbfgnt = pvwgtwwbqd ojbumynjfa (hnlcqhcntz, wgibjytbem - rmfmzjcbsh)
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Regulation

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