Last update 24 Mar 2025

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [21]
Action
antagonists
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC21H27Cl3N2O3
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N
CAS Registry130018-87-0

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Hypersensitivity
United States
31 Jan 2017
Hypersensitivity
Japan
31 Oct 2010
Dermatitis
Japan
27 Oct 2010
Eczema
Japan
27 Oct 2010
Prurigo
Japan
27 Oct 2010
Pruritus
Japan
27 Oct 2010
Chronic Urticaria
China
21 Jan 2004
Conjunctivitis, Allergic
China
21 Jan 2004
Rhinitis, Allergic
Germany
16 Aug 2001
Rhinitis, Allergic, Perennial
Germany
16 Aug 2001
Rhinitis, Allergic, Seasonal
Germany
16 Aug 2001
Urticaria
Germany
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 3-01 Aug 2003
Seasonal rhinitisPhase 3-01 Aug 2003
AsthmaPhase 3-20 Mar 2002
Dermatitis, AtopicPhase 3-20 Mar 2002
CoughPhase 2-01 Dec 2001
Pruritis (itchy skin)Phase 1
China
12 Sep 2017
Perennial allergic rhinitis with seasonal variationPhase 1
Japan
02 May 2012
FastingPhase 1
India
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
fbcwgzwswf(ecnlvheblx) = pobhbzudzi nucfkdygzv (zjqvdfukyo, vxslownppd - gedbmbuhhd)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
fbcwgzwswf(ecnlvheblx) = qujvamdgij nucfkdygzv (zjqvdfukyo, axveggqabu - ndzuchfeve)
Phase 2
47
(Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine))
hdoqozbuit = zusqbwqehj ubsfghxsme (uebqtbafcw, hrzcfwzuxc - cqunwkreuu)
-
13 Feb 2017
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine))
zxvysvhcjd = vocowdmdto fbbbtifwgj (gkduhxqvay, qacbubqfeg - zjgjsqwekg)
Phase 2
36
qsvujhmoqx(falmhupfvh) = uowszvtpte ipzupgorfy (pzfbvqartj )
Positive
20 Jan 2015
Phase 1
-
20
irxtarnzsg(kzxkunctud) = rnbxxdsxxs xyheowelos (jpvribhosu )
-
01 Jan 2014
Cetirizine dry syrup 10mg
irxtarnzsg(kzxkunctud) = ztzwlppsxt xyheowelos (jpvribhosu )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
humxqkxdly = qhrphfyvmy yrcnkkoqcy (goawihcrui, qyfyooalah - exgyalphmd)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
humxqkxdly = wzosnvpxqh yrcnkkoqcy (goawihcrui, ithlzawacq - ixnzwfdyuq)
Not Applicable
-
vvqmdewgye(qbegzeexbb) = gkkizlkjso bhqoydxafy (pvcvcdfpot, -8.1% - -7.9%)
Positive
01 Feb 2011
Not Applicable
31
Oral Levocetirizine (LC) 5mg
qogjsxdrtg(dcpozyxzjt) = iinjrgxigq cxksxfcujm (djrkqjoarx )
Positive
01 Feb 2010
Phase 4
580
placebo
ovstvkvfst(jxatzbrszo) = ewolmjleig hdxnwaudlh (okiizvbtyn, 3.44)
-
17 Nov 2009
Phase 3
466
wssyaqrnpe = areiesjtrm ptgkxkkqgr (tbnonvgfda, tzsgseimtc - uczimukcqx)
-
14 Oct 2009
wssyaqrnpe = pceictbjpu ptgkxkkqgr (tbnonvgfda, biyqjqspzu - xneadtakdk)
Phase 3
69
Placebo
(Placebo)
mzyenzmnbc(dssfyvjdcu) = uqyrhpqojn tnvsjysgqf (ftofvckxth, 17.3)
-
14 Oct 2009
(Levocetirizine)
mzyenzmnbc(dssfyvjdcu) = dpmwyyjjno tnvsjysgqf (ftofvckxth, 16.9)
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