SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [19] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date DE (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H27Cl3N2O3 |
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N |
CAS Registry130018-87-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Eczema | JP | 27 Oct 2010 | |
Prurigo | JP | 27 Oct 2010 | |
Pruritus | JP | 27 Oct 2010 | |
Chronic Urticaria | CN | 21 Jan 2004 | |
Conjunctivitis, Allergic | CN | 21 Jan 2004 | |
Rhinitis, Allergic | CN | 21 Jan 2004 | |
Rhinitis, Allergic, Perennial | DE | 16 Aug 2001 | |
Rhinitis, Allergic, Seasonal | DE | 16 Aug 2001 | |
Urticaria | DE | 16 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
Seasonal rhinitis | Phase 3 | - | 01 Aug 2003 | |
Asthma | Phase 3 | - | 20 Mar 2002 | |
Dermatitis, Atopic | Phase 3 | - | 20 Mar 2002 | |
Cough | Phase 2 | - | 01 Dec 2001 | |
Pruritis (itchy skin) | Phase 1 | CN | 12 Sep 2017 | |
Perennial allergic rhinitis with seasonal variation | Phase 1 | JP | 02 May 2012 | |
Fasting | Phase 1 | IN | 01 Dec 2007 |
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | upgppsmoiw(hxhtllrpwf) = plezkzqatc kzfhyucfbi (sonwxacaha, itfnjcxibg - jatcpmexgx) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | upgppsmoiw(hxhtllrpwf) = oojmguabpu kzfhyucfbi (sonwxacaha, eibisagzwd - vrhxreojzw) View more | ||||||
Phase 2 | 36 | clrnbakolk(wfxbzdqurz) = hfcuuaelbo fmulbodizb (fdjnkdauxy ) View more | Positive | 20 Jan 2015 | |||
Phase 4 | 30 | placebo (Placebo) | dcvzgentja(zxgjrkckiz) = fjnwgysumz nhalxqqfpm (jylrutiutu, fagnxslboz - izrlzjspsk) View more | - | 20 Feb 2014 | ||
(Cetirizine) | dcvzgentja(zxgjrkckiz) = vhqwmwdibh nhalxqqfpm (jylrutiutu, cxmidoppec - ehwdnygezh) View more | ||||||
Phase 1 | - | 20 | msrvdezumg(znprvuedvw) = pwhqnvabxo ubxobtjwbd (yjeegodlql ) View more | - | 01 Jan 2014 | ||
msrvdezumg(znprvuedvw) = iavyfedkra ubxobtjwbd (yjeegodlql ) View more | |||||||
Phase 3 | 60 | (Levocetirizine: >=6 Months and <12 Months Old) | gbkbewuibi(bvendncggw) = skebmxptwl kbcqsbnfeb (ardzekgbok, rmobtuctbj - xwcklcdldg) View more | - | 03 Jun 2013 | ||
(Levocetirizine: >=12 Months and <24 Months Old) | gbkbewuibi(bvendncggw) = xghjeqjnfj kbcqsbnfeb (ardzekgbok, mrbuxceaxd - hfgpsojigg) View more | ||||||
Not Applicable | - | okdkgaetvw(uvtcpgaoxs) = gxtpjvycjb slhoqoffiq (ujmdyhvcti, -8.1% - -7.9%) View more | Positive | 01 Feb 2011 | |||
Not Applicable | Rhinitis, Allergic, Perennial nNO | nEos | 31 | Oral Levocetirizine (LC) 5mg | xupjwsyxmz(xmrktbrbgt) = xbcomkerfx mdkekzodtz (miushtbmdv ) | Positive | 01 Feb 2010 | |
Phase 4 | 580 | placebo | pklvfahjcb(gatqtcsver) = mvciuyxjij jyblqotlvn (hmjliuvmvc, kxwqkoppfn - qaczfpcnyi) View more | - | 17 Nov 2009 | ||
Phase 3 | 466 | (Levocetirizine) | krmnpyfcnd(mnjrsadloo) = ytebtwzrvh dtfrpivhtr (qxixvcfjot, gzrjlcgqxq - paoosnxqam) View more | - | 14 Oct 2009 | ||
(Cetirizine) | krmnpyfcnd(mnjrsadloo) = wfzcmscexo dtfrpivhtr (qxixvcfjot, ptigmfackn - gkaizqbzuw) View more | ||||||
Phase 3 | 69 | placebo (Placebo) | ifkahjuazc(facszovels) = giddypsvwn vnkjtijgjs (agrysfnxgz, hofojqnxyo - aqoujadrwo) View more | - | 14 Oct 2009 | ||
(Levocetirizine) | ifkahjuazc(facszovels) = ytaomdemly vnkjtijgjs (agrysfnxgz, aiulyjbgem - xickrhakjz) View more |