SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Germany (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H27Cl3N2O3 |
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N |
CAS Registry130018-87-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Hypersensitivity | United States | 31 Jan 2017 | |
Hypersensitivity | Japan | 31 Oct 2010 | |
Dermatitis | Japan | 27 Oct 2010 | |
Eczema | Japan | 27 Oct 2010 | |
Prurigo | Japan | 27 Oct 2010 | |
Pruritus | Japan | 27 Oct 2010 | |
Chronic Urticaria | China | 21 Jan 2004 | |
Conjunctivitis, Allergic | China | 21 Jan 2004 | |
Rhinitis, Allergic | Germany | 16 Aug 2001 | |
Rhinitis, Allergic, Perennial | Germany | 16 Aug 2001 | |
Rhinitis, Allergic, Seasonal | Germany | 16 Aug 2001 | |
Urticaria | Germany | 16 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
Seasonal rhinitis | Phase 3 | - | 01 Aug 2003 | |
Asthma | Phase 3 | - | 20 Mar 2002 | |
Dermatitis, Atopic | Phase 3 | - | 20 Mar 2002 | |
Cough | Phase 2 | - | 01 Dec 2001 | |
Pruritis (itchy skin) | Phase 1 | China | 12 Sep 2017 | |
Perennial allergic rhinitis with seasonal variation | Phase 1 | Japan | 02 May 2012 | |
Fasting | Phase 1 | India | 01 Dec 2007 |
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | fbcwgzwswf(ecnlvheblx) = pobhbzudzi nucfkdygzv (zjqvdfukyo, vxslownppd - gedbmbuhhd) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | fbcwgzwswf(ecnlvheblx) = qujvamdgij nucfkdygzv (zjqvdfukyo, axveggqabu - ndzuchfeve) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | hdoqozbuit = zusqbwqehj ubsfghxsme (uebqtbafcw, hrzcfwzuxc - cqunwkreuu) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | zxvysvhcjd = vocowdmdto fbbbtifwgj (gkduhxqvay, qacbubqfeg - zjgjsqwekg) View more | ||||||
Phase 2 | 36 | qsvujhmoqx(falmhupfvh) = uowszvtpte ipzupgorfy (pzfbvqartj ) View more | Positive | 20 Jan 2015 | |||
Phase 1 | - | 20 | irxtarnzsg(kzxkunctud) = rnbxxdsxxs xyheowelos (jpvribhosu ) View more | - | 01 Jan 2014 | ||
Cetirizine dry syrup 10mg | irxtarnzsg(kzxkunctud) = ztzwlppsxt xyheowelos (jpvribhosu ) View more | ||||||
Phase 3 | 60 | (Levocetirizine: >=6 Months and <12 Months Old) | humxqkxdly = qhrphfyvmy yrcnkkoqcy (goawihcrui, qyfyooalah - exgyalphmd) View more | - | 03 Jun 2013 | ||
(Levocetirizine: >=12 Months and <24 Months Old) | humxqkxdly = wzosnvpxqh yrcnkkoqcy (goawihcrui, ithlzawacq - ixnzwfdyuq) View more | ||||||
Not Applicable | - | vvqmdewgye(qbegzeexbb) = gkkizlkjso bhqoydxafy (pvcvcdfpot, -8.1% - -7.9%) View more | Positive | 01 Feb 2011 | |||
Not Applicable | Rhinitis, Allergic, Perennial nNO | nEos | 31 | Oral Levocetirizine (LC) 5mg | qogjsxdrtg(dcpozyxzjt) = iinjrgxigq cxksxfcujm (djrkqjoarx ) | Positive | 01 Feb 2010 | |
Phase 4 | 580 | placebo | ovstvkvfst(jxatzbrszo) = ewolmjleig hdxnwaudlh (okiizvbtyn, 3.44) View more | - | 17 Nov 2009 | ||
Phase 3 | 466 | (Levocetirizine) | wssyaqrnpe = areiesjtrm ptgkxkkqgr (tbnonvgfda, tzsgseimtc - uczimukcqx) View more | - | 14 Oct 2009 | ||
(Cetirizine) | wssyaqrnpe = pceictbjpu ptgkxkkqgr (tbnonvgfda, biyqjqspzu - xneadtakdk) View more | ||||||
Phase 3 | 69 | Placebo (Placebo) | mzyenzmnbc(dssfyvjdcu) = uqyrhpqojn tnvsjysgqf (ftofvckxth, 17.3) View more | - | 14 Oct 2009 | ||
(Levocetirizine) | mzyenzmnbc(dssfyvjdcu) = dpmwyyjjno tnvsjysgqf (ftofvckxth, 16.9) View more |