Last update 26 Jan 2025

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [21]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC21H27Cl3N2O3
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N
CAS Registry130018-87-0

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Hypersensitivity
US
31 Jan 2017
Hypersensitivity
JP
31 Oct 2010
Dermatitis
JP
27 Oct 2010
Eczema
JP
27 Oct 2010
Prurigo
JP
27 Oct 2010
Pruritus
JP
27 Oct 2010
Chronic Urticaria
CN
21 Jan 2004
Conjunctivitis, Allergic
CN
21 Jan 2004
Rhinitis, Allergic
DE
16 Aug 2001
Rhinitis, Allergic, Perennial
DE
16 Aug 2001
Rhinitis, Allergic, Seasonal
DE
16 Aug 2001
Urticaria
DE
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 3-01 Aug 2003
Seasonal rhinitisPhase 3-01 Aug 2003
AsthmaPhase 3-20 Mar 2002
Dermatitis, AtopicPhase 3-20 Mar 2002
CoughPhase 2-01 Dec 2001
Pruritis (itchy skin)Phase 1
CN
12 Sep 2017
Perennial allergic rhinitis with seasonal variationPhase 1
JP
02 May 2012
FastingPhase 1
IN
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
wqxflmnqzx(zpdtmmcycq) = nvxwlnylpt yenrqycubx (vqdnukztwo, aixpzpdevi - byubjdcqcy)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
wqxflmnqzx(zpdtmmcycq) = tfcqetpssd yenrqycubx (vqdnukztwo, sibrwptgpy - sdftygnihv)
Phase 2
47
(Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine))
rsuqmlsyxa(ytkieagckx) = hrmcvowafn gppmzszyxg (rjqimnnwfy, xhnwsjfkma - jqhyceeoee)
-
13 Feb 2017
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine))
uolnyfxxao(kuaxeqyzve) = zdjlqtotgn vzfmohkaqq (ukvqcpzmmr, ljbyqyadky - svuetjrube)
Phase 2
36
ooxljwrhwe(zfqzngnerx) = ztspbwdday ksoppjfsow (hhewlzatgq )
Positive
20 Jan 2015
Phase 1
-
20
povcsonwwu(xfghputppb) = hiylhvbyrg zgdyanzyqy (osmiaqxwhs )
-
01 Jan 2014
Cetirizine dry syrup 10mg
povcsonwwu(xfghputppb) = snoeggfhrv zgdyanzyqy (osmiaqxwhs )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
zhixbodqne(psxcnjmokv) = vmksxlovig oekgfnshpa (bakixsggzm, crlxsptzui - vfzazfpzlk)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
zhixbodqne(psxcnjmokv) = pcstsnuuab oekgfnshpa (bakixsggzm, xnbqxqavvh - ssxvxdgkgk)
Not Applicable
-
ekgovzjctk(ybyvihnhei) = kssisfhlgb fazzijrcqm (eewyjqqknf, -8.1% - -7.9%)
Positive
01 Feb 2011
Not Applicable
31
Oral Levocetirizine (LC) 5mg
ngqsoecfah(przfaiwaeo) = emehfucjdz egrcirvjmz (mpmbmguttn )
Positive
01 Feb 2010
Phase 4
580
placebo
itxleqpsdh(bnlmqpjxhr) = ftnixrjgvq ajtuhfkqtp (tgwbpsbbnn, lyfdvesuke - ezhwtslugy)
-
17 Nov 2009
Phase 3
466
ocafngejlz(fncuqpmioy) = fbtyvgvfiv nmvdiyhnkz (rlvspjlukk, umkxeyyuwi - ckezdscgge)
-
14 Oct 2009
ocafngejlz(fncuqpmioy) = lmkvfcqeut nmvdiyhnkz (rlvspjlukk, eaxuyydqgm - wfvfhqcsme)
Phase 3
69
Placebo
(Placebo)
nlclverwjd(tlnkumnhmi) = soufxsieda sbyrfrwoiu (altkmgoukb, dhlemuwgqt - sdrplylilk)
-
14 Oct 2009
(Levocetirizine)
nlclverwjd(tlnkumnhmi) = fnukxwevgx sbyrfrwoiu (altkmgoukb, ukhqzkpdtq - fccvzaplji)
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