SummaryApproved by the FDA in March 1996, Fexofenadine is a puzzling small molecule drug that works as an H1 receptor antagonist. This drug hinders the action of histamine at the H1 receptor, reducing respiratory hypersensitivity, urticaria, dermatitis, pruritus, and other skin diseases. Fexofenadine is primarily indicated for these conditions and helps alleviate their symptoms. Sanofi is the enigmatic originator organization of Fexofenadine, which has been widely used in clinical practice. Despite its wide usage, the specific mechanism of action of this drug remains unclear. Nevertheless, Fexofenadine is an essential weapon in the treatment of allergic and related conditions, despite the fact that it may cause drowsiness and dry mouth, among other side effects. The variability of side effects and the imprecise mode of action of Fexofenadine highlight the need for further research to fully comprehend the mechanisms of action of drugs. |
Drug Type Small molecule drug |
Synonyms Allegra 5%, Fexofenadine hydrochloride (JP17/USP), Fexofenading Hydrochloride + [17] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date GB (11 Mar 1996), |
Regulation- |
Molecular FormulaC32H40ClNO4 |
InChIKeyRRJFVPUCXDGFJB-UHFFFAOYSA-N |
CAS Registry153439-40-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00671 | Fexofenadine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Pruritus | JP | 15 Apr 2002 | |
Chronic Urticaria | US | 25 Feb 2000 | |
Rhinitis, Allergic | KR | 04 May 1998 | |
Urticaria | AU | 10 Jan 1997 | |
Rhinitis, Allergic, Seasonal | GB | 11 Mar 1996 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dermatitis, Atopic | Phase 3 | JP | 01 Nov 2010 | |
Rhinitis perennial | Phase 3 | JP | 01 Oct 2010 | |
Rhinitis, Allergic, Perennial | Phase 3 | JP | 01 Oct 2010 | |
Persistent asthma | Phase 3 | US | 01 Feb 2002 | |
Persistent asthma | Phase 3 | CR | 01 Feb 2002 | |
Persistent asthma | Phase 3 | GT | 01 Feb 2002 | |
Persistent asthma | Phase 3 | HU | 01 Feb 2002 | |
Persistent asthma | Phase 3 | MX | 01 Feb 2002 | |
Persistent asthma | Phase 3 | PL | 01 Feb 2002 | |
Persistent asthma | Phase 3 | RU | 01 Feb 2002 |
Phase 3 | 95 | (Arm A (Active-active)) | lodtgjgdtd(dcudrxktyc) = drlfpixahk rrzepylghn (viiatixnja, dfwgtizspt - dtfllyxnxp) View more | - | 16 May 2024 | ||
Placebo (Arm B (Placebo-active)) | lodtgjgdtd(dcudrxktyc) = lbahkvzrfz rrzepylghn (viiatixnja, wwnkwpnhps - vbdpupfvuu) View more | ||||||
Phase 4 | 152 | gout flare prophylaxis regimen+acetaminophen+methylprednisolone+fexofenadine+methotrexate+Pegloticase (Pegloticase + MTX) | juwdzeshry(yteiypesug) = taapbguwlx unvfpospun (meucthhnsg, fjeczqvpkf - ivnmavjywe) View more | - | 16 May 2022 | ||
(Pegloticase + Placebo) | juwdzeshry(yteiypesug) = rmhgqjqfzb unvfpospun (meucthhnsg, diidrdajpi - gmuaofamtb) View more | ||||||
Not Applicable | 145 | lrofaxpava(dkqcwowqqf) = ytjsaytikn epgwxzhoud (kctnxytryf ) View more | - | 20 May 2012 | |||
lrofaxpava(dkqcwowqqf) = preawdxzgf epgwxzhoud (kctnxytryf ) View more | |||||||
Not Applicable | - | Fexofenadine HCl 6 mg/mL Suspension | npzgctigwy(vjujvhnmje) = Ten treatment-emergent adverse events (TEAEs) occurred in seven subjects. No serious, one moderate intensity (pyrexia) and nine mild intensity TEAEs were reported. All TEAEs resolved without sequelae. vehizzvbuh (eqcsauvgyy ) View more | Positive | 01 Jan 2007 |