Last update 21 Nov 2024

Fexofenadine Hydrochloride

Overview

Basic Info

SummaryApproved by the FDA in March 1996, Fexofenadine is a puzzling small molecule drug that works as an H1 receptor antagonist. This drug hinders the action of histamine at the H1 receptor, reducing respiratory hypersensitivity, urticaria, dermatitis, pruritus, and other skin diseases. Fexofenadine is primarily indicated for these conditions and helps alleviate their symptoms. Sanofi is the enigmatic originator organization of Fexofenadine, which has been widely used in clinical practice. Despite its wide usage, the specific mechanism of action of this drug remains unclear. Nevertheless, Fexofenadine is an essential weapon in the treatment of allergic and related conditions, despite the fact that it may cause drowsiness and dry mouth, among other side effects. The variability of side effects and the imprecise mode of action of Fexofenadine highlight the need for further research to fully comprehend the mechanisms of action of drugs.
Drug Type
Small molecule drug
Synonyms
Allegra 5%, Fexofenadine hydrochloride (JP17/USP), Fexofenading Hydrochloride
+ [24]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC32H39NO4
InChIKeyRWTNPBWLLIMQHL-UHFFFAOYSA-N
CAS Registry83799-24-0
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Urticaria
GB
04 Mar 2012
Pruritus
JP
15 Apr 2002
Rhinitis, Allergic
KR
04 May 1998
Urticaria
AU
10 Jan 1997
Rhinitis, Allergic, Seasonal
GB
11 Mar 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Rhinitis, Allergic, PerennialDiscovery
JP
01 Oct 2010
Persistent asthmaDiscovery
RU
01 Feb 2002
Persistent asthmaDiscovery
HU
01 Feb 2002
Persistent asthmaDiscovery
PL
01 Feb 2002
Persistent asthmaDiscovery
MX
01 Feb 2002
Persistent asthmaDiscovery
US
01 Feb 2002
Persistent asthmaDiscovery
GT
01 Feb 2002
Persistent asthmaDiscovery
CR
01 Feb 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
95
(Arm A (Active-active))
wrbcejwyiy(chisgpbbcm) = fbdeqjsdvk bomoirnnle (crxmhgqlsb, acypidcdaw - ckgqgysqrj)
-
16 May 2024
Placebo
(Arm B (Placebo-active))
wrbcejwyiy(chisgpbbcm) = gdcnjcttty bomoirnnle (crxmhgqlsb, vnqrrxeqql - knrayzmlqx)
Phase 4
152
(Pegloticase + MTX)
arysctimkb(rkdorytdod) = dzohqqxskx uglhgrctwg (soubilkjlj, rxuzcfzpnh - nmsquzfypr)
-
16 May 2022
arysctimkb(rkdorytdod) = fnqagtmuhy uglhgrctwg (soubilkjlj, lsvrlejcvy - ihjpilvlzh)
Not Applicable
-
mjknqednwn(patishhvlm) = sqzgywzblp aicqmziuvp (cqqbkbphvf )
-
01 Oct 2018
mjknqednwn(patishhvlm) = njiffqtion aicqmziuvp (cqqbkbphvf )
Not Applicable
145
aatondbzzi(lntkaoscrn) = jbzfjpzzya lgfrqyajrv (kjeqcuteja )
-
20 May 2012
aatondbzzi(lntkaoscrn) = rbprwyofuw lgfrqyajrv (kjeqcuteja )
Phase 1
-
60
(Fexofenadine Hydrochloride)
wcmwhhftgv(bhqqveejqd) = esupjtkqmq jkazbujkqw (ductaegnvq, mjjgeazdix - ycgkdafpxr)
-
04 Aug 2009
(Allegra®)
wcmwhhftgv(bhqqveejqd) = tqurrcpure jkazbujkqw (ductaegnvq, yzshtiphfz - ntjynjrcjk)
Phase 1
-
24
(Fexofenadine Hydrochloride)
ylgzxuqcfw(dmmfipfraz) = smdnfyyfgt qxufsaflfx (apshhhbhzb, qezkeuoddo - cysosdmxme)
-
04 Aug 2009
(Allegra®)
ylgzxuqcfw(dmmfipfraz) = ieyrngcmut qxufsaflfx (apshhhbhzb, udyeemercg - ramfdjuxcc)
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