AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), VDCCs blockers(Voltage-gated calcium channel blockers)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Essential HypertensionHypertension

Inactive Indication-

Originator Organization

Novartis Pharma AG

Active Organization

Novartis AGNovartis Europharm Ltd.

Novartis Pharmaceuticals Corp.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (30 Apr 2009),

Hypertension

Regulation-

Structure

Molecular FormulaC26H31ClN2O8S

InChIKeyZPBWCRDSRKPIDG-UHFFFAOYSA-N

CAS Registry111470-99-6

View All Structures (3)

Clinical Trials associated with Amlodipine besilate/valsartan/hydrochlorothiazide

CTR20182354 / Active, not recruitingPhase 3

Aprocitentan 治疗难治性高血压（RHT）受试者的多中心、盲法、随机、平行组、 3 期研究

[Translation] A Multicenter, Blinded, Randomized, Parallel-Group, Phase 3 Study of Aprocitentan in Subjects with Refractory Hypertension (RHT)

这项研究的目的是评价在难治性高血压患者中在其他抗高血压药物治疗的基础上添加新药Aprocitentan在的降血压作用以及这种作用的持久性。

[Translation]

The purpose of this study was to evaluate the blood pressure-lowering effect of the new drug Aprocitentan added to other antihypertensive drug treatment in patients with resistant hypertension and the durability of this effect.

Start Date27 May 2019

Sponsor / Collaborator

Hangzhou Tigermed Consulting Co., Ltd.

NCT02742467 / CompletedPhase 4IIT

Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans

The creole study is a A Multi-centre, multinational, randomised single-blind, parallel group, three-armed superiority trial which is aimed at comparing the efficacy of three "free" combinations of two anti-hypertensive agents on 24 hour ambulatory systolic blood pressure (ASBP) in black African hypertensive patients.

Start Date07 Jun 2017

Sponsor / Collaborator

University of Abuja

[+7]

NCT00931710 / CompletedPhase 4

A 12-week Multicenter, Randomized, Double-blind, Parallel-group, Active-control Study to Evaluate the Antihypertensive Efficacy and Safety of Valsartan/Amlodipine-based Regimen Versus a Losartan-based Regimen in Patients With Stage 2 Systolic Hypertension

This study will compare the antihypertensive efficacy and safety of a valsartan/amlodipine-based treatment with a losartan-based treatment in patients with Stage 2 systolic hypertension (high blood pressure, mean systolic blood pressure greater than 160 and less than 200 mmHg).

Start Date01 Jul 2009

Sponsor / Collaborator

Novartis AG

100 Clinical Results associated with Amlodipine besilate/valsartan/hydrochlorothiazide

100 Translational Medicine associated with Amlodipine besilate/valsartan/hydrochlorothiazide

100 Patents (Medical) associated with Amlodipine besilate/valsartan/hydrochlorothiazide

Literatures (Medical) associated with Amlodipine besilate/valsartan/hydrochlorothiazide

15 Jun 2009·The Medical letter on drugs and therapeutics

Exforge HCT.

Article

100 Deals associated with Amlodipine besilate/valsartan/hydrochlorothiazide

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	C09DX01	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Essential Hypertension	LI	Novartis Europharm Ltd.	15 Oct 2009
Essential Hypertension	IS	Novartis Europharm Ltd.	15 Oct 2009
Essential Hypertension	NO	Novartis Europharm Ltd.	15 Oct 2009
Essential Hypertension	EU	Novartis Europharm Ltd.	15 Oct 2009
Hypertension	US	Novartis Pharmaceuticals Corp.	30 Apr 2009

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESC2018	Phase 3	Edema	2,268	Amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ)	mfxeklrsdp(mpphemqkts) = lymkcebvts cseutckbfe (acijhofips )	-	26 Aug 2018
				Valsartan/amlodipine (Val/Aml)	mfxeklrsdp(mpphemqkts) = mmqkcwdmhr cseutckbfe (acijhofips )
NCT00931710 (EXALT, CTgov)	Phase 4	Hypertension	488	valsartan, amlodipine, HCTZ (Valsartan/Amlodipine/HCTZ)	yuaqlpjaxy(avrlxheagc) = cliowqglbo lsjccpncwg (eblracgpwp, gkweugtcgu - zbcbyybcgf) View more	-	04 Feb 2011
				Losartan, HCTZ+HCTZ+valsartan, amlodipine (Losartan/HCTZ)	yuaqlpjaxy(avrlxheagc) = irzyliylee lsjccpncwg (eblracgpwp, rfkcyzpiod - smhyhyrrhv) View more

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