Last update 04 Nov 2024

Fenofibrate

Overview

Basic Info

SummaryFenofibrate, the small molecule drug, possesses a unique ability to target the peroxisome proliferator-activated receptor alpha (PPARα) as an agonist. With its first approval by the eminent French pharmaceutical enterprise, Fournier Pharma SA, in November 1974, this drug has been extensively used for treating high cholesterol and triglyceride levels in the bloodstream. Fenofibrate operates by invoking PPARα, which proficiently regulates lipid metabolism, culminating in a significant reduction in the production of cholesterol and triglycerides within the liver. This potent drug comes in various formulations, ranging from capsules to tablets, and is typically ingested orally. Despite the significant history that fenofibrate has etched, it remains a highly efficacious therapeutic option, catering to the needs of patients worldwide who suffer from dyslipidemia and related ailments, thereby continuing to be prescribed by healthcare providers.
Drug Type
Small molecule drug
Synonyms
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester, Fenofibrate (JAN/USP/INN), Finofibrate
+ [27]
Target
Mechanism
PPARα agonists(Peroxisome proliferator-activated receptor α agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC20H21ClO4
InChIKeyYMTINGFKWWXKFG-UHFFFAOYSA-N
CAS Registry49562-28-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperlipidemias
JP
30 Mar 2011
Hyperlipidemias
JP
30 Mar 2011
Hyperlipidemias
JP
30 Mar 2011
Hyperlipidemia, Familial Combined
US
10 Aug 2007
Chylomicronemia, Familial, Due to Circulating Inhibitor of Lipoprotein Lipase
US
04 Sep 2001
Congenital Abnormalities
US
04 Sep 2001
Coronary Disease
US
04 Sep 2001
Diabetes Mellitus
US
04 Sep 2001
Hyperlipoproteinemia Type I
US
04 Sep 2001
Hyperlipoproteinemia Type IV
US
04 Sep 2001
Hypothyroidism
US
04 Sep 2001
Pancreatitis
US
04 Sep 2001
Primary hypercholesterolemia
US
04 Sep 2001
Hypercholesterolemia
FR
04 Nov 1974
Hypertriglyceridemia
FR
04 Nov 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 1Phase 3
AU
03 Nov 2016
Diabetes Mellitus, Type 1Phase 3
HK
03 Nov 2016
Diabetes Mellitus, Type 1Phase 3
NZ
03 Nov 2016
Diabetes Mellitus, Type 1Phase 3
GB
03 Nov 2016
Diabetic NephropathiesPhase 3
AU
03 Nov 2016
Diabetic NephropathiesPhase 3
HK
03 Nov 2016
Diabetic NephropathiesPhase 3
NZ
03 Nov 2016
Diabetic NephropathiesPhase 3
GB
03 Nov 2016
Diabetic RetinopathyPhase 3
AU
03 Nov 2016
Diabetic RetinopathyPhase 3
HK
03 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
1,151
jucxvdtfuo(rbtmwiwuzx) = hpzraomlyh xcrkgccykd (khfxypcswi )
Positive
21 Jun 2024
Placebo
jucxvdtfuo(rbtmwiwuzx) = eplkkgpmpd xcrkgccykd (khfxypcswi )
Phase 4
1,151
Fenofibrate 145-mg tablets
bucgzbnddd(gukotyanbi) = bsphbeztcf sidyrtlprp (qhralusmau )
Positive
21 Jun 2024
Placebo
bucgzbnddd(gukotyanbi) = zjaasjhgct sidyrtlprp (qhralusmau )
Phase 2
10
(Active)
gnonxetngo(bregsobxkq) = uyudcetbkt ouqulnkvve (rgttjqrezx, nycaunaxlg - hwzijxdtiq)
-
28 Sep 2023
Placebo
(Placebo)
gnonxetngo(bregsobxkq) = raibtidfmn ouqulnkvve (rgttjqrezx, rettnwvwpn - nechhbygbc)
Phase 3
Epilepsy
Adjuvant
340
epoholmwgu(mbktlfgiuu) = notably reduced in fenofibrate group compared to placebo group pimptqxmig (zfksjbqxim )
Positive
04 Sep 2023
Placebo
Not Applicable
117
ybqfjlfgkw(koyjtlqenr) = hzwvpobnpf zwxurdjnbc (urvrmogerg, 51.9 - 76.8)
Positive
09 Mar 2023
ybqfjlfgkw(koyjtlqenr) = jltwtbupay zwxurdjnbc (urvrmogerg, 69.9 - 92.9)
Phase 3
551
(K-877)
avewdlylby(rsyibnhglm) = clmjgwznaa kkuwrmaxzu (guvemhecvn, wghjpvtmlh - xwyxwyizos)
-
30 Nov 2022
Placebo+K-877
(Placebo)
avewdlylby(rsyibnhglm) = jbvkatsjam kkuwrmaxzu (guvemhecvn, mabwlvddwv - wqjwdbicnq)
Not Applicable
692
Statin plus fenofibrate
mobezrjaak(fyrfmjuedq): HR = 0.89 (95% CI, 0.81 - 0.98), P-Value = 0.022
Positive
21 Sep 2022
Statin-only
Not Applicable
COVID-19
D-dimer | CRP | ferritin ...
384
pjxfnhqnpz(sjjrghgnps) = ogxjbdtqlk ssfupopefe (ajzvvhmhvv )
Negative
04 Sep 2022
pjxfnhqnpz(sjjrghgnps) = tgekpcswpm ssfupopefe (ajzvvhmhvv )
Not Applicable
75
eswcnasaba(ydkoeilsct) = siggkyabur cdhyjcthyn (dmekygoihz )
Positive
25 Jun 2022
Not Applicable
-
qfyfhrqpwh(fsscbfbpyt) = nkwafeubnn vyjesnifka (kljygkcpqg, 0.67 - 1.07)
-
01 Jun 2022
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