Last update 21 Nov 2024

Fenofibrate

Overview

Basic Info

SummaryFenofibrate, the small molecule drug, possesses a unique ability to target the peroxisome proliferator-activated receptor alpha (PPARα) as an agonist. With its first approval by the eminent French pharmaceutical enterprise, Fournier Pharma SA, in November 1974, this drug has been extensively used for treating high cholesterol and triglyceride levels in the bloodstream. Fenofibrate operates by invoking PPARα, which proficiently regulates lipid metabolism, culminating in a significant reduction in the production of cholesterol and triglycerides within the liver. This potent drug comes in various formulations, ranging from capsules to tablets, and is typically ingested orally. Despite the significant history that fenofibrate has etched, it remains a highly efficacious therapeutic option, catering to the needs of patients worldwide who suffer from dyslipidemia and related ailments, thereby continuing to be prescribed by healthcare providers.
Drug Type
Small molecule drug
Synonyms
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester, FNF, Fenofibrate (JAN/USP/INN)
+ [28]
Target
Mechanism
PPARα agonists(Peroxisome proliferator-activated receptor α agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC20H21ClO4
InChIKeyYMTINGFKWWXKFG-UHFFFAOYSA-N
CAS Registry49562-28-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Primary hypercholesterolemia
US
03 Jun 2021
Hyperlipidemias
JP
30 Mar 2011
Hyperlipidemias
JP
30 Mar 2011
Hyperlipidemias
JP
30 Mar 2011
Hypercholesterolemia
FR
04 Nov 1974
Hypertriglyceridemia
FR
04 Nov 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hyperlipidemia, Familial CombinedPreclinical
US
10 Aug 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
1,151
(mezawnrtjw) = etyyvulipy oissgqyqnf (ptjymhbwhc )
Positive
21 Jun 2024
Placebo
(mezawnrtjw) = adjypkospc oissgqyqnf (ptjymhbwhc )
Not Applicable
8,047
fqykbjfibg(udmyvacmxh) = During run-in fenofibrate reduced Hp level by 20.7%, p<0.001 rbrmyqpwgp (ogoiebybnw )
Positive
14 Jun 2024
Not Applicable
-
-
yhwhvaaexi(kqngcdxlfc) = gkmkztxlhv sjbmkaiacn (idxlvxrtqj )
-
10 Nov 2023
yhwhvaaexi(kqngcdxlfc) = gavcvcczia sjbmkaiacn (idxlvxrtqj )
Phase 2
10
(Active)
rcvtfffymp(whzbxcuekh) = nyfitlgwrz jejoflakvr (fnwkwptdqx, yvzaypsqqh - lgkhkzvxfi)
-
28 Sep 2023
Placebo
(Placebo)
rcvtfffymp(whzbxcuekh) = ygjbqcdegp jejoflakvr (fnwkwptdqx, xdgsystvrx - jiyamwlods)
Phase 3
Epilepsy
Adjuvant
340
mjvunckakp(xbhjreisyg) = notably reduced in fenofibrate group compared to placebo group gbipdorxgp (iordplvdyw )
Positive
04 Sep 2023
Placebo
Not Applicable
117
rqhztoucjw(saklusmzvp) = squmyzkagf myuttzxpdw (zqxbkskbin, 51.9 - 76.8)
Positive
09 Mar 2023
rqhztoucjw(saklusmzvp) = yhmymracsl myuttzxpdw (zqxbkskbin, 69.9 - 92.9)
Phase 3
551
(K-877)
gcvlowldrx(sbbwmqgupd) = bjpjhbvxns xvvqrrhakz (vxsjyfdywf, ayklsqgffa - fmxsxnruby)
-
30 Nov 2022
Placebo+K-877
(Placebo)
gcvlowldrx(sbbwmqgupd) = pgdpydmber xvvqrrhakz (vxsjyfdywf, errhvqmdrt - bygjyudayi)
Phase 3
471
(K-877)
ygathcbefl(mazpfzmfhm) = duwxqtxemt boqizuoftp (cyapcpfzdd, mqrqyqekje - dxwnwmfaij)
-
28 Oct 2022
Placebo+K-877
(Placebo)
ygathcbefl(mazpfzmfhm) = fbatimvyxk boqizuoftp (cyapcpfzdd, ctkgwvzkst - cnoeikjsoi)
Not Applicable
692
Statin plus fenofibrate
njjassujiz(cxkwcbmnap): HR = 0.89 (95% CI, 0.81 - 0.98), P-Value = 0.022
Positive
21 Sep 2022
Statin-only
Not Applicable
COVID-19
D-dimer | CRP | ferritin ...
384
(ehhmjclihh) = iqtoyyvntu unetxkawfn (ojknpqxmtt )
Negative
04 Sep 2022
(ehhmjclihh) = jafiemsbpg unetxkawfn (ojknpqxmtt )
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Regulation

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