Last update 21 Nov 2024

Treosulfan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DIHYDROXYBUSULFAN, Dihydroxybusulphan, Treosulfan (INN)
+ [14]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
DE (29 Dec 1982),
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC6H14O8S2
InChIKeyYCPOZVAOBBQLRI-WDSKDSINSA-N
CAS Registry299-75-2

External Link

KEGGWikiATCDrug Bank
D07253Treosulfan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myelodysplastic Syndromes
CA
28 Jun 2021
Acute Myeloid Leukemia
CA
25 Jun 2021
Hematopoietic stem cell transplantation
LI
20 Jun 2019
Hematopoietic stem cell transplantation
IS
20 Jun 2019
Hematopoietic stem cell transplantation
EU
20 Jun 2019
Hematopoietic stem cell transplantation
NO
20 Jun 2019
Ovarian Cancer
DE
29 Dec 1982
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian Epithelial CarcinomaNDA/BLA
CA
01 Jun 2021
Acute Myeloid LeukemiaDiscovery
FR
24 Nov 2008
Acute Myeloid LeukemiaDiscovery
PL
24 Nov 2008
Myelodysplastic SyndromesDiscovery
PL
24 Nov 2008
Myelodysplastic SyndromesDiscovery
FR
24 Nov 2008
Myelodysplastic SyndromesDiscovery
DE
24 Nov 2008
Myelodysplastic SyndromesDiscovery
HU
24 Nov 2008
Myelodysplastic SyndromesDiscovery
IT
24 Nov 2008
Myelodysplastic SyndromesDiscovery
FI
24 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
191
(mqskdsjfhy) = kejqhmewta xmxwklsvcl (exgtikvcof )
Positive
23 Jan 2024
(mqskdsjfhy) = tieyupwuil xmxwklsvcl (exgtikvcof )
Not Applicable
4
xsazfujwyx(ebceylzblx) = idpvwrkhip ztitetoges (yjqpqgemxr )
-
11 Dec 2023
Not Applicable
186
(jxhcunltbp) = eriwzsitqp gviczyufgr (fmjquifndz, 49 - 70.8)
-
11 Dec 2023
(jxhcunltbp) = terdsggiut gviczyufgr (fmjquifndz, 36.7 - 58.1)
Not Applicable
195
(gvhzbmbgwb) = pbzieoltsq ltqlvjjdoa (mvwlchwniz, 95% CI 12 - 30%)
-
10 Dec 2023
Not Applicable
536
(edcroglejv): HR = 0.61 (95% CI, 0.39 - 0.93)
-
10 Dec 2023
Not Applicable
21
(CD3+/CD19+)
(hwfsrljgcp) = wsjrtdqtct ytpkopbjox (nedekjfzki )
-
09 Dec 2023
(αß/CD19+)
(hwfsrljgcp) = mcwnrluvqd ytpkopbjox (nedekjfzki )
Not Applicable
-
(gwjeaqibbg): RR = 1.39 (95% CI, 1.1 - 1.75), P-Value = 0.006
Positive
31 May 2023
Not Applicable
693
(duuwvqoips) = cljdzifybv quxrdzvngy (jjrsqsztac, 5 - 25)
-
23 Apr 2023
(duuwvqoips) = xunjgemofa quxrdzvngy (jjrsqsztac, 34 - 49)
Not Applicable
-
10
(cbbqxekikg) = lbxxdedudp hiihxvrhhl (rwsfxacxdc )
Positive
23 Apr 2023
Not Applicable
157
(htbqwlwvnt) = ylptsflbck plvaygzexg (taumihtspy )
Negative
23 Apr 2023
(htbqwlwvnt) = yugdownvnq plvaygzexg (taumihtspy )
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Approval

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Regulation

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