The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition.

Start Date01 Mar 2025

Sponsor / Collaborator

University of Texas Medical Branch

[+1]

NCT06668922

/ RecruitingNot ApplicableIIT

Fecal Bile Acids, Fecal Short Chain Fatty Acids and the Intestinal Microbiota in Patients with Irritable Bowel Syndrome (IBS) and Control Volunteers: Diet Challenge

The study will investigate the relationship between fecal bile acids, short-chain fatty acids (SCFAs), and the gut microbiota in irritable bowel syndrome (IBS). The central hypothesis of this study is that specific shifts in the GI microbiome composition correlate with altered colonic SCFAs and BAs and contribute to IBS symptoms. Primary aims include: (a) identifying GI microbiome signatures in IBS subtypes (IBS-C and IBS-D) and matched controls, and test if microbiome signatures in these groups correlate with fecal SCFAs and bacterial fermentation of an indigestible carbohydrate (inulin) after a dietary challenge (fecal inulin), and (b) determining if GI microbiome signatures in IBS subtypes and controls correlate with fecal BAs or markers of SCFA production (fecal SCFAs or inulin) and test if BAs correlate with fecal SCFAs or inulin.
The target population is adults ages 18-65 years meeting Rome IV criteria for IBS (both diarrhea- and constipation-predominant, IBS-D and IBS-C) and asymptomatic controls. Primary outcomes will be fecal bile acid excretion and profile, short-chain fatty acid excretion and profile, colonic transit, and fecal microbiota. Secondary outcomes will be stool characteristics based on responses to validated bowel diaries. Stool samples will be collected from participants during the last 2 days of a 4-day 100 g fat diet and split into 3 samples for fecal microbiota, SCFA, and bile acid analysis.

Start Date28 Nov 2024

Sponsor / Collaborator

University of California, Los Angeles

NCT06738329

/ RecruitingNot ApplicableIIT

Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut Microbiome

The goal of this study is to investigate whether a seaweed derived food additive, carrageenan, has an impact on the human gut microbiome in vivo. The primary purpose is to assess whether consumption of a carrageenan containing product for 4 weeks can alter the bacterial composition of the gut microbiome in healthy individuals and whether the addition of a prebiotic fibre, inulin, to the product has an enhanced beneficial impact of the gut composition. The main questions to answer are:
Does the consumption of a confectionary item containing carrageenan and inulin lead to a positive impact on the faecal microbial community when compared to the confectionary item containing no carrageenan and no inulin (placebo)? Participants will be asked to consume 2 gummy sweets for 4 week period and provide stool and urine samples on 3 occasions over a 9 week period.
Does the consumption of a confectionary item containing carrageenan and inulin improve gastrointestinal comfort measured using overall SHS-GI score when compared to baseline measurements recorded during run in period?

Start Date01 Oct 2024

Sponsor / Collaborator

The University of Reading

100 Clinical Results associated with Inulin

100 Translational Medicine associated with Inulin

100 Patents (Medical) associated with Inulin

3,500

Literatures (Medical) associated with Inulin

01 May 2025·International Journal of Biological Macromolecules

Hemp seed oil-based emulsion gels stabilized by soybean protein isolate, inulin, and glyceryl monostearate: Phase inversion and baking application

Article

Author: Qiu, Yang ; Zhang, Jie ; Zhu, Jiajin ; Liao, Hengyi ; Guo, Jiaxin ; Xue, Chenxu

This study delved into the potential of hemp seed oil (HSO)-based emulsion gels stabilized by soybean isolate protein (SPI) using high-speed dispersion method as innovative butter substitutes in the bakery industry, offering a dual benefit of health and functionality. In order to better mimic the properties of butter, the storage stability and plasticity of the emulsion gel were increased by successive attempts to add inulin to the SPI solution and glycerol monostearate (GMS) to the hemp seed oil as structuring agents. There was phase inversion as GMS added, 2 % GMS addition caused phase inverted from O/W to semibicontinuous, and W/O appeared when GMS increased to 4 % or more. This was because that GMS crystals could bind neighboring droplets, reduced the spatial resistance provided by the SPI, collapsed the original oil-in-water structure. This novel emulsion was integrated as a novel fat replacer in cakes, and 25 % replacement cakes was regarded as optimal substitution of commercial butter through texture profile analysis and sensory assessment. This research advances the potential use of HSO emulsion gels as substitutes for fats in baking applications.

01 Apr 2025·Food Microbiology

Assessment of the ability of Lactococcus lactis 537 to bind aflatoxin M1 in the presence of inulin and Terminalia ferdinandiana (Kakadu plum)

Article

Author: Almutairi, Batlah ; Fletcher, Mary T ; Dong, Anran ; Turner, Mark S ; Sultanbawa, Yasmina ; Hong, Hung Trieu

One promising method for the detoxification of Aflatoxin M1 (AFM1) involves the use of probiotic bacteria combined with prebiotics. This approach is both safe and cost-effective, while also offering additional health benefits. The objective of this study was to investigate the capacity of Lactococcus lactis 537 (Lc. Lactis 537) to bind AFM1 in milk and phosphate-buffered saline (PBS), either in the presence or absence of inulin or Kakadu plum fruit powder (KP), which are prebiotic substances. Lc. Lactis 537 was incubated for 0, 1, 2, and 24 h at 30 °C, with or without inulin or KP, to assess its ability to bind and reduce AFM1 levels. The concentration of AFM1 was determined using liquid chromatography-mass spectrometry (LC-MS9) during the different incubation periods. The results demonstrated that Lc. Lactis 537 significantly reduced the initial concentration of AFM1 in both milk and PBS after 24 h of incubation. Moreover, the presence of inulin or KP enhanced the binding and reduction capacity of Lc. Lactis 537. This suggests that the synbiotic effect where probiotic bacteria like Lc. Lactis work in synergy with prebiotics such as inulin or KP could play a critical role in the removal of AFM1 from contaminated substances. In conclusion, the synbiotic of Lc. Lactis 537 with inulin or KP represents a promising biological approach for AFM1 detoxification, and further research is warranted to explore its potential applications in food safety.

01 Apr 2025·Clinical Nutrition ESPEN

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Article

Author: Hanhineva, Kati ; De Timary, Philippe ; Kärkkäinen, Olli ; Leyrolle, Quentin ; Bindels, Laure B ; Neyrinck, Audrey M ; Layé, Sophie ; Amadieu, Camille ; Stärkel, Peter ; Ahmed, Hany ; Leclercq, Sophie ; Delzenne, Nathalie M ; Koistinen, Ville

BACKGROUND AND AIMSAlcohol Use Disorder (AUD) is a psychiatric disorder characterized notably by gut microbial dysbiosis and insufficient dietary fiber intake. This study aims to investigate the effect of dietary fiber placebo-controlled intervention in patients suffering from AUD during a three-week period of alcohol withdrawal, in order to discover microbial-derived metabolites that could be involved in metabolic and behavioral status.METHODSA randomized, double-blind, placebo-controlled study was performed with 50 AUD patients supplemented with inulin (prebiotic dietary fiber) or maltodextrin (placebo) during 17 days. Fecal microbiota composition, plasma and fecal metabolomics (liquid chromatography coupled to mass spectrometry), blood markers of inflammation and hepatic alterations and psychological assessment (questionnaires) were analyzed before and after the intervention.RESULTSFecal metabolomics revealed 14 metabolites significantly modified by inulin versus placebo treatment (increased N8-acetylspermidine and decreased indole-3-butyric acid, 5-amino valeric acid betaine (5-AVAB) and bile acids). 13 plasma metabolites differentiated both treatments (higher levels of long-chain fatty acids, medium-chain acylcarnitines and sphingomyelin species, and reduced 3-methylhistidine by inulin versus placebo). Fecal Lachnoclostridium correlated with 6 of the identified fecal metabolites, whereas plasma lipidic moieties positively correlated with fecal Ruminococcus torques group and Flavonifractor. Interestingly, parameters reflecting liver alterations inversely correlated with sphingomyelin (SM 36:2).CONCLUSIONSThree weeks of inulin supplementation during alcohol withdrawal leads to specific and different changes in the plasma and fecal metabolome of AUD patients, some of these gut microbiota-related metabolites being correlated with liver function.TRIAL REGISTRATIONNCT03803709, https://clinicaltrials.gov/ct2/show/NCT03803709.

News (Medical) associated with Inulin

28 May 2024

·www.sciencedaily.com

Weight gain is kicked to the curb in antipsychotic drug breakthrough

Thousands of Australians struggle with serious mental health conditions. But when the recommended treatment involves antipsychotic medications, the side effects are excess kilos, which only adds weight to an already complex diagnosis. Now, new research shows that antipsychotics can be reformulated with a strategically engineered coating that not only mitigates unwanted weight gain but also boosts serotonin levels by more than 250%. Thousands of Australians struggle with serious mental health conditions. But when the recommended treatment involves antipsychotic medications, the side effects are excess kilos, which only adds weight to an already complex diagnosis. Now, world first research from the University of South Australia shows that antipsychotics can be reformulated with a strategically engineered coating that not only mitigates unwanted weight gain but also boosts serotonin levels by more than 250%. Funded by the Hospital Research Foundation (THRF) Group, researchers specifically tested Lurasidone, a drug used in the treatment of schizophrenia and bipolar depression, finding that the new coatings target the gut microbiome to improve drug absorption by 8-fold, while concurrently overcoming common side effects such as weight gain. The coatings are created from tiny core-shell particles made from the dietary fibre, inulin, and bioactive medium chain triglycerides. The inulin shell boosts the gut microbiome by providing an energy source for gut bacteria, while the medium chain triglycerides facilitate drug absorption into the bloodstream. It's a breakthrough discovery that has the potential to change the lives of millions of people worldwide. Lead researcher UniSA's Dr Paul Joyce says microbiota-targeting microcapsules have the potential to improve treatment outcomes of mental health medications. "Most patients suffering from schizophrenia or bipolar disorder are prescribed a range of antipsychotic medications, which trigger significant adverse effects by disrupting the gut microbiome -- the microbial ecosystem that naturally colonises the gut," Dr Joyce says. "The most notable side effect is weight gain, with many patients often seeing increases of between 10-15% of their body weight after just three months of treatment. "Because the gut microbiome plays a major role in regulating overall health, especially mood and cognition, the detrimental impact of these medications on the microbiome often makes them counterproductive. "Instead of improving mood and cognition, the medication leads to a cascading cycle of poor mental and metabolic health as patients now struggle with excess weight and mental health issues. "To make matters worse, most antipsychotics need to be consumed with food to maximise their effect. Yet for a very vulnerable patient population, ensuring this happens is challenging, with most patients gaining suboptimal drug levels. "Clearly, new strategies are needed to eliminate side effects and the need for these medications to be taken with food -- and that's exactly what we've achieved with the drug Lurasidone. "This research shows that when antipsychotic drugs are formulated with our new smart core-shell microparticles, drug absorption increases, mitigating the need for the medication to be consumed with food, while also boosting the diversity and abundance of the gut microbiome to overcome common side effects, such as weight gain. "Importantly, because we are not developing new drugs, rather reformulating them, the new therapies can be fast-tracked for clinical use, so we could expect them within the next few years rather than the 10-15 years needed for new drug molecules to be approved by regulatory bodies." Next steps are to test the efficacy of these re-formulated therapies within human patients, with longer term goals being to extend these technologies across all mental health therapies, including anti-depressants, to mitigate any adverse effects.

Microbial therapy

08 Apr 2024

·www.prnewswire.com

Premium Jane Introduces Innovative Keto Product Line to Enhance Ketogenic Diet Experience

SCOTTSDALE, Ariz., April 8, 2024 /PRNewswire/ -- Premium Jane, a household name in the health supplements industry for nearly a decade, has unveiled a line of new products that are designed to complement and accelerate the benefits of a ketogenic diet. The "keto" diet, known for its emphasis on low-carb/high-fat calorie intake, has surged in popularity recently for its ability to help rapidly shed pounds, increase energy levels, and sharpen mental focus and acuity. After years of researching how to optimize this diet, Premium Jane has developed a range of products that are engineered to speed up the results of keto, as well as maintain the effects of the ketogenic state. The cornerstone of Premium Jane's new Keto line is a once-a-day fiber supplement formulated with inulin and chicory root - two crucial (but often overlooked) components of the ketogenic diet. Inulin is a type of soluble plant fiber that bypasses much of the digestive system until it reaches the colon. There, it serves as a prebiotic fiber and nourishes beneficial bacteria (such as Bifidobacteria and Lactobacilli) in the gut. By stimulating the growth of beneficial bacteria, inulin helps maintain a healthy balance of gut microflora. This is essential for balanced digestion, immune function, mental sharpness, and a whole lot more. Another key function of the product is its potential to help slow down emptying of the stomach, thereby enhancing feelings of fullness and boosting weight loss efforts. "We are beyond thrilled to unveil our new Keto product line," says Premium Jane CEO Jeff Yauck. "The ketogenic state isn't just a trend; we, along with research experts across the world, believe it really is the future of health and weight loss." In addition to the inulin fiber supplement, Premium Jane has also released a line of dietary capsules containing 7-keto DHEA - a naturally occurring metabolite of dehydroepiandrosterone (DHEA). 7-keto DHEA has been studied for its potential to enhance metabolic rate and support fat loss, making it an ideal complement to a ketogenic lifestyle. Additionally, Premium Jane is offering Keto BHB gummies, which contain a unique blend of calcium, magnesium, and sodium beta-hydroxybutyrate (BHB). Research is showing BHB to have profound effects on mental clarity, sustained energy, and accelerated fat burning. To place an order or to learn more about the new Keto product range from Premium Jane, visit the company's official website at . Contact: Premium Jane [email protected] SOURCE Premium Jane

08 Mar 2024

·www.prnewswire.com

Burt's Bees® Showcases Clinical Efficacy of Aloe and Prebiotic Containing Products in Addressing Common Skin Concerns

Clinical studies presented at the 2024 American Academy of Dermatology Annual Meeting demonstrate how nature-based products support the microbiome in compromised skin, while improving barrier function and hydration DURHAM, N.C., March 8, 2024 /PRNewswire/ -- Burt's Bees, the #1 dermatologist recommended natural skin care brand* and a pioneer in naturally-derived lip and skin care solutions, announced its latest research findings on the benefits of nature-based products to maintain and protect skin health and hydration. The studies will be presented at the American Academy of Dermatology (AAD) Annual Meeting from March 8-12, 2024. The latest research findings from Burt's Bees highlight: The efficacy of an aloe-containing moisturizer in improving skin barrier function and hydration in sensitive skin populations The impact of a moisturizer containing aloe and rice milk in supporting the skin microbiome for those with atopic dermatitis and rosacea The tolerability of a topical formulation in populations with mild to moderate acne "Whether our aim is to improve barrier function, boost hydration or support the microbiome, we focus on bringing the best solutions nature has to offer to consumers as we have done for more than 40 years," said Hemali Gunt, Ph.D., head of clinical and scientific affairs at Burt's Bees. "Burt's Bees has a deep understanding of both facial and lip skin, which is at the foundation of our research and development efforts as we continue to pioneer the use of new ingredients and innovations in the natural skin care space." New Burt's Bees data that will be presented at AAD 2024 includes: The effectiveness of aloe vera and rice extract-containing moisturizing cream in improving and maintaining barrier function and hydration in xerotic skin; Gunt H., Levy S.; Online Poster About the Research: A nature-based moisturizing cream containing aloe and rice extract was studied in 32 female participants with moderately dry skin The study evaluated the effectiveness of the moisturizing cream in improving skin hydration and barrier function/transepidermal water loss When compared to baseline, results demonstrated a significant improvement in moisturization and skin barrier function in individuals with dry and sensitive skin A multi-functional moisturizer containing aloe vera and rice extract maintains a diverse and balanced facial skin microbiome in sensitive skin; Gunt H., Ahmad N. and Sivamani R.; Online Poster About the Research: A baseline-controlled study evaluating the effectiveness of a moisturizing cream containing aloe vera and rice extract was conducted in 42 female participants over six weeks Participants had either atopic dermatitis or rosacea with visible redness Results showed that the nature-based moisturizer significantly increased skin hydration while supporting the skin microbiome without disrupting the skin barrier Daily use of prebiotic-containing topical formulation balances and restores skin microbiome in subjects with mild to moderate acne; Gunt H., Levy S., and Sivamani R.; March 8, 2024, poster presentation from 2:20-2:25 p.m. PST in the Sails Pavilion, Poster Center 1 About the Research: A six-week baseline-controlled study evaluated the efficacy and tolerability of a topical formulation containing prebiotics in participants with mild to moderate acne Investigator and participant-assessed tolerability demonstrated that the product was well tolerated while changes in the appearance of acne and skin microbiome were consistent with improvement in overall skin condition of those with mild to moderate acne "The skin microbiome is fundamental to supporting a healthy skin barrier. Barrier dysfunction in individuals with acne-prone skin results in alterations and imbalances in the microbiome, leading to inflammation and breakouts," said Stanley Levy, M.D., a board-certified dermatologist in Chapel Hill, North Carolina and study consultant. "This research demonstrates that a topical nature-based gel cream containing inulin, an effective prebiotic, can assist in supporting a balanced microbiome in patients with mild to moderate acne and replenish moisture content without provoking breakouts." Burt's Bees will also highlight naturally-derived products containing aloe, shea and coconut on-site at AAD, booth location #3217, where attendees can learn more about the brand's nature-based product research and core product offerings, including forthcoming research in the lip health space. To learn more about the proven power of Burt' Bees nature-based products, visit for our clinical data and resources. About Burt's Bees | is the #1 dermatologist recommended natural skin care brand, born in the woods of Maine, and known for its original Beeswax Lip Balm. Burt's Bees products are consciously made with ingredients from nature to nourish skin from head to toe. From responsible sourcing to mindful packaging and landfill-free operations, Burt's Bees is made with care by nature, for nature, for all—since 1984. NYSE: CLX-B. *Based on a November 2023 NielsenIQ national survey of U.S. Dermatologists SOURCE Burt's Bees

Clinical Result

100 Deals associated with Inulin

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KEGG	Wiki	ATC	Drug Bank
D00171	Inulin	V04CH01	DB00638

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Indication	Country/Location	Organization	Date
Diagnostic agents	Japan	Fuji Yakuhin Co., Ltd.	11 Oct 2005

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04118010 (CTgov)	Phase 4	Cystic Fibrosis	40	Vitamin D3+inulin (Vitamin D3 and Inulin)	kxnxwinamc(wpgkfkczig) = yemdnfsmha ebiwqjucdk (dneddpxifj, bykpdlojqi - nuiyjjxwor) View more	-	07 Feb 2024
				Placebo Inulin+Vitamin D3 (Vitamin D3 and Placebo Inulin)	kxnxwinamc(wpgkfkczig) = dhprnvplls ebiwqjucdk (dneddpxifj, iudxeudisu - vqisgeibdx) View more
UEGW2023	Not Applicable	-	-	Inulin	gxskrjncdo(gjmozfexaj) = avkccyjiag eqteeaevss (ouihaqyugy ) View more	-	15 Oct 2023
				INULIN (Placebo)	gxskrjncdo(gjmozfexaj) = zlarlfkfqz eqteeaevss (ouihaqyugy ) View more
DDW2023	Not Applicable	-	-	inulin (LPS)	uabrjplvxy(kkfhjodmnp) = qvzclodfew ycyehdcngc (ykskdezssr )	-	07 May 2023
				Inulin	uabrjplvxy(kkfhjodmnp) = vrebbwedjk ycyehdcngc (ykskdezssr )
NCT02794766 (CTgov)	Phase 2	Tongue Diseases \| Stomatodysodia	45	Placebo	lsoccrwmbw(vvhljrjgzs) = grwwkddqew tefsyjakjq (gndvikepis, hcwfevtawd - feixtxqquc) View more	-	19 Aug 2020
ASN2015	Not Applicable	Hypomagnesemia Maintenance TRPM6 (rs3750425 and rs2274924)	133	Inulin supplementation	rsrxewwhst(bzsivpwnks) = qetydmxqoh lptraylwuf (elujsrxlhu ) View more	Positive	03 Nov 2015
				Inulin (Healthy non-PPI users)	rmusisjiqk(xzzoebjcvb) = nqyfmydden gabntezywu (gjjglshuwy )
UEGW2015	Not Applicable	Irritable bowel syndrome with constipation	-	Functional food jelly containing inulin, curcumin and pyridoxine	(edmieajisk) = vldtbalpcw qhtryuwydb (cfzoafgfco ) View more	-	01 Oct 2015
				functional food product containing inulin and curcumin (Standard diet)	(edmieajisk) = zgcgxfwvpk qhtryuwydb (cfzoafgfco ) View more
NCT00335504 (CTgov)	Phase 2	Rectal Cancer \| Colonic Cancer \| Precancerous Conditions	85	laboratory biomarker analysis+atorvastatin calcium (Arm I (Atorvastatin Calcium))	rolumrpuhj(filzqwkfkf) = cgyybponef mgzetjmnrh (rnjqeypmkl, mkhrnofoky - bsybnywjiq) View more	-	08 Feb 2013
				laboratory biomarker analysis+sulindac (Arm II (Sulindac))	rolumrpuhj(filzqwkfkf) = onefecqusn mgzetjmnrh (rnjqeypmkl, nvhnkmmyhi - hoolecdfvd) View more
NCT01483092 (Pubmed \| Am J Clin Nutr)	Not Applicable	Iron deficiency	32	Inulin	uudfnarxzk(rsduwhweai) = ogdkjaawne lqmcwmqkfh (eeescunjla, 8.0% - 28.9%)	-	01 Aug 2012
				Placebo	uudfnarxzk(rsduwhweai) = fphsqyftcb lqmcwmqkfh (eeescunjla, 8.1% - 24.3%)

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