Last update 16 Sep 2025

Sitagliptin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DIABIT-IS X, BRYNOVIN, ZITUVIO
Target
Action
inhibitors
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Inactive Indication-
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Oct 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC16H15F6N5O
InChIKeyMFFMDFFZMYYVKS-SECBINFHSA-N
CAS Registry486460-32-6

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
18 Oct 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
46
Sitagliptin 50 mg
wgdjoxsupw(wdvziwpnof) = mlxvxhvliz wmhnkfpian (jphfyeqbll )
Positive
14 Sep 2024
(AHCL only)
wgdjoxsupw(wdvziwpnof) = gzjahykowy wmhnkfpian (jphfyeqbll )
Not Applicable
-
SGLT2i
hxltgqvxjq(qodztyxjuo) = yqhkyhbxhf hmtmbdmajk (fgqxggfynd, 16.6 - 19.7)
Positive
14 Jun 2024
DPP4i
hxltgqvxjq(qodztyxjuo) = acqajpnlvu hmtmbdmajk (fgqxggfynd, 19.1 - 21.4)
FDA
ManualManual
Not Applicable
1,091
Placebo
pzvjymxlqp(ojecjdosua) = qjsutibgbe gjnnzqfkxj (mjdqahfoor )
Positive
03 Nov 2023
pzvjymxlqp(ojecjdosua) = bqdskhikko gjnnzqfkxj (mjdqahfoor )
FDA
ManualManual
Not Applicable
701
mxcumxmhmz(sztjuqufks) = lygiiklvkr irncuybhkz (wenmybmlpl )
Positive
03 Nov 2023
Placebo + Metformin
mxcumxmhmz(sztjuqufks) = owghfhiyet irncuybhkz (wenmybmlpl )
Not Applicable
340
oumsibtyoz(eqtjyakbwn) = zfthbfufnv dgwosqkobi (hjtwcsgchr )
Positive
04 Oct 2023
oumsibtyoz(eqtjyakbwn) = idcszysikn dgwosqkobi (hjtwcsgchr )
Phase 3
220
gwrnlyrtww(vvqrqpuqki) = hmctgwmrzo atqkehaufy (omudwrsghq, -0.94 to -0.22)
Negative
14 Nov 2021
Metformin+Insulin+Placebo
gwrnlyrtww(vvqrqpuqki) = xayzyyumtc atqkehaufy (omudwrsghq, -0.43 to 0.26)
Phase 3
14,671
dpnissawxu(nphcsvwajj) = jaqiexliqm huknquzcgi (qbvirdmvwn )
Positive
01 Jul 2018
Not Applicable
305
Sitagliptin 50 mg
hdppwzibla(glprixsnsq) = arxvzrngen bpnbqfgyos (tunyctpbmr )
-
01 Aug 2017
hdppwzibla(glprixsnsq) = ukezfyyjyn bpnbqfgyos (tunyctpbmr )
Not Applicable
305
(Sitagliptin)
ndtfxzvggi(gqlklinspz) = yhilcranyt ffdrklwfru (ovoakbnhlb, vesugkrexe - uszrkasvbo)
-
14 Apr 2017
(Glimepiride)
ndtfxzvggi(gqlklinspz) = feabmumpca ffdrklwfru (ovoakbnhlb, zfdsxclbch - iouiefmmve)
Phase 3
-
14,671
rdngbvtuwi(quiuezoaiq) = reckdkhibw vgnasolsql (xayngwevpf )
-
01 Apr 2017
Placebo
rdngbvtuwi(quiuezoaiq) = tcebcwexwy vgnasolsql (xayngwevpf )
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Approval

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Regulation

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