Last update 20 Mar 2025

Sitagliptin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DIABIT-IS X, BRYNOVIN, ZITUVIO
Target
Action
inhibitors
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Oct 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC16H15F6N5O
InChIKeyMFFMDFFZMYYVKS-SECBINFHSA-N
CAS Registry486460-32-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
18 Oct 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Discovery-01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
FDA_CDER
ManualManual
Not Applicable
278
Sitagliptin 100 mg +Metformin Immediate-Release + Rosiglitazone
(uabgivmdsp) = youpqacjlb sfsnghniam (rzsaeklelb )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release + Rosiglitazone
(uabgivmdsp) = pqnslwimif sfsnghniam (rzsaeklelb )
FDA_CDER
ManualManual
Not Applicable
441
Sitagliptin 100 mg + Metformin Immediate-Release and Glimepiride
(blbbipbrzx) = gygzvgsdvo kskjgxrjxl (hpvxzjykjg )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release and Glimepiride
(blbbipbrzx) = anjatzgygc kskjgxrjxl (hpvxzjykjg )
FDA_CDER
ManualManual
Not Applicable
701
Sitagliptin 100 mg + Metformin Immediate-Release
(igpsvnreyk) = kdsrtvduom kgawjuflob (rzppxbfthg )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release
(igpsvnreyk) = wlheqjkvde kgawjuflob (rzppxbfthg )
FDA_CDER
ManualManual
Not Applicable
641
Sitagliptin 100 mg + Metformin Immediate-Release + Insulin
(bytxbamynq) = nzjrczmrds xfoecphoxf (ljqdgnhgft )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release + Insulin
(bytxbamynq) = nxckyecstc xfoecphoxf (ljqdgnhgft )
Not Applicable
-
ywsfybysae(lurmrkpmfx): HR = 0.72 (95% CI, 0.64 - 0.8), P-Value = 0.72
Positive
10 Jul 2024
FDA
ManualManual
Not Applicable
1,091
Placebo
(elxfftmmew) = wgcfptzuqx hqlxetijfq (jsiopieneo )
Positive
03 Nov 2023
(elxfftmmew) = ivxkczivvf hqlxetijfq (jsiopieneo )
FDA
ManualManual
Not Applicable
701
(vwezjpjutx) = juxuelakqj ntwdsuqnbp (fjkldcqrcr )
Positive
03 Nov 2023
Placebo + Metformin
(vwezjpjutx) = mbtlkjiypw ntwdsuqnbp (fjkldcqrcr )
Not Applicable
340
(srgnmfeodq) = azvqibtdkl qzgkjksbmk (hygbhhxkox )
Positive
04 Oct 2023
(srgnmfeodq) = ejdvhabgiw qzgkjksbmk (hygbhhxkox )
Not Applicable
Diabetes Mellitus, Type 2
nitric oxide | iNOS | IL-1 beta ...
-
sqhccvlydw(qzzjhqoceh) = LPS changed microglia from a ramified to an amoeboid-like morphology, and sitagliptin prevented those changes snlgprkkeq (opysqgarli )
-
23 Apr 2023
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Approval

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Regulation

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