By conducting this study, we hope to assess if simethicone (also known as Gas Relief or GasX) has an effect on improving gas pain and bloating specifically in patients undergoing foregut procedures to include bariatric procedures (sleeve gastrectomy, Roux-en-Y gastric bypass), hiatal hernia, and gastric surgery.
The purpose of this research is to gather information on the safety and effectiveness of simethicone. Simethicone (more commonly known as Gas Relief or Gas-X) relieves pressure, bloating, and fullness commonly referred to as gas. It is FDA approved. The use of this medication in this research study is consistent with labeling indications.

Start Date01 Mar 2025

Sponsor / Collaborator

Madigan Army Medical Center

NCT06581783

/ CompletedNot ApplicableIIT

Impact of Timing of Premedication on Mucosal Visibility During Endoscopy

UGI endoscopy(esophagogastroduodenoscopy) is the main diagnostic modality for direct visualization ,real time assessment and interpretation of findings encountered. The evaluation of esophagogastroduodenoscopy (EGD) quality measures encompasses several categories, such as structure, procedure, result, and adverse events. The peri-EGD period procedures fall under the procedural area, which is primarily concerned with preventing and minimising missed diagnoses.
. More aid in the identification and characterisation of gastrointestinal mucosal lesions is provided by endoscopes equipped with improved imaging technologies, such as multiband or narrow-band imaging (NBI). Despite these advancements of technological aspects, the unclean mucosal surface of the stomach can make these high-end pieces of equipment virtually useless To visualize properly and diagnose accurately there should be clear visibility of mucus apart from operator experience. Since the stage at diagnosis of upper gastrointestinal cancer is a major factor in survival, early detection is essential in improving the prognosis of patients the main factors responsible for hinderance of mucosal visibility are mucus foam and bubbles, which requires additional care for the clearance to enhance the vision and also decrease endoscopy duration by alleviating the need of repeated flushing and suctioning during endoscopy. The froth and bubbles are made of mucous secretions mixed with gastric juice and bile. Simethicone (polydimethylsiloxane and silicon dioxide) has been proven to be a promising defoaming agent as an endoscopic premedication in removing bubbles . Simethicone works by reducing the surface tension of air bubbles, and releases the trapped air by causing small bubbles to coalesce and collapse . N-acetylcysteine (nac), a mucolytic agent, has also been used as premedication acts by removing the mucous overlying the gastrointestinal mucosa 4-point scale described by Basford et al
1. No adherent mucus and clear views of the mucosa.
2. A thin coating of mucus that did not obscure views of the mucosa.
3. Some mucus/bubbles partially obscuring views of the mucosa (i. E. A small mucosal lesion might be missed without flushing
4. Heavy mucus/bubbles obscuring views of the mucosa (i. E. Extensive flushing is needed to avoid missing small mucosal lesions)

Start Date01 Dec 2024

Sponsor / Collaborator

Asian Institute of Gastroenterology Pvt Ltd.

100 Clinical Results associated with Simethicone

100 Translational Medicine associated with Simethicone

100 Patents (Medical) associated with Simethicone

361

Literatures (Medical) associated with Simethicone

01 Apr 2025·AMERICAN JOURNAL OF GASTROENTEROLOGY

Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi-Society Task Force on Colorectal Cancer

Review

Author: Jacobson, Brian C. ; Burke, Carol A. ; Gross, Seth A. ; May, Folasade P. ; Robertson, Douglas J. ; Shaukat, Aasma ; Dominitz, Jason A. ; Patel, Swati G. ; Anderson, Joseph C.

This document is an update to the 2014 recommendations for optimizing the adequacy of bowel cleansing for colonoscopy from the US Multi-Society Task Force on Colorectal Cancer, which represents the American College of Gastroenterology, the American Gastroenterological Association, and the American Society for Gastrointestinal Endoscopy. The US Multi-Society Task Force developed consensus statements and key clinical concepts addressing important aspects of bowel preparation for colonoscopy. The majority of consensus statements focus on individuals at average risk for inadequate bowel preparation. However, statements addressing individuals at risk for inadequate bowel preparation quality are also provided. The quality of a bowel preparation is defined as adequate when standard screening or surveillance intervals can be assigned based on the findings of the colonoscopy. We recommend the use of a split-dose bowel preparation regimen and suggest that a 2 L regimen may be sufficient. A same-day regimen is recommended as an acceptable alternative for individuals undergoing afternoon colonoscopy, but we suggest that a same-day regimen is an inferior alternative for individuals undergoing morning colonoscopy. We recommend limiting dietary restrictions to the day before a colonoscopy, relying on either clear liquids or low-fiber/low-residue diets for the early and midday meals. We suggest the adjunctive use of oral simethicone for bowel preparation before colonoscopy. Routine tracking of the rate of adequate bowel preparations at the level of individual endoscopists and at the level of the endoscopy unit is also recommended, with a target of >90% for both rates.

01 Mar 2025·DIGESTIVE AND LIVER DISEASE

Comparative efficacy of different bowel preparations for colonoscopy: A network meta-analysis.

Review

Author: Fabbri, A ; Repici, A ; Amata, M ; Fuccio, L ; Marasco, G ; Maida, M ; Ramai, D ; Hassan, C ; Vassallo, R ; Facciorusso, A ; Vitello, A ; Mocciaro, F ; Di Mitri, R

BACKGROUND AND AIMS:

The quality of a colonoscopy is heavily reliant on the effectiveness of bowel cleansing. Various cleansing solutions are currently available, but their comparative efficacy remains uncertain. This systematic review and network meta-analysis aims to compare the performance of different bowel preparations for colonoscopy.

METHODS:

MEDLINE, Embase, Scopus, and the Cochrane Library were systematically searched for randomized controlled trials (RCTs) comparing the efficacy of different bowel preparations. The primary outcome was cleansing success (CS), and the secondary outcome was adenoma detection rate (ADR).

RESULTS:

On network meta-analysis for CS (22 RCTs, 7179 patients, 14 bowel preparations), 2 L PEG + simethicone (RR = 1.25 [95 %CI = 1.13-1.37]), 2 L PEG + lactulose (RR = 1.22 [95 %CI = 1.10-1.38]) and 1 L PEG + ascorbate (ASC) (RR = 1.03 [95 %CI = 1.01-1.06]) were significantly superior to 2 L PEG + ASC. Overall, 2 L PEG + lactulose resulted as the best product (SUCRA 0.94), followed by 2 L PEG + simethicone (SUCRA 0.93). On network meta-analysis for ADR (17 RCTs, 6639 patients, 11 bowel preparations), only 2 L PEG + simethicone (RR = 1.60 [95 %CI = 1.05-2.43]) resulted significantly superior to 2 L PEG + ASC.

CONCLUSIONS:

2 L PEG + simethicone, 2 L PEG + lactulose, and 1 L PEG + ASC seemed to provide high rates of CS, albeit only 2 L PEG + simethicone was associated with significantly higher ADR. Consequently, these products should be preferred for bowel preparation of colonoscopy. Further randomized studies with adequate sample sizes are needed for a more accurate comparison of these products on ADR.

01 Nov 2024·ADVANCES IN THERAPY

Evaluation of Aluminum and Magnesium Absorption Following the Oral Administration of an Antacid Suspension Containing Magaldrate in Healthy Women Under Fed Conditions

Article

Author: Burgos Castillo, Maria Juliana ; do Prado Assunção, Leandro ; Arbeláez Quintero, Isaac ; Iorgatchof Xavier, Kamila ; Cruz Palacios, Maria Juliana ; Calafatti Carandina, Silvana Aparecida

INTRODUCTION:

Antacids are commonly used during pregnancy, and they are approved for the relief of symptoms of gastroesophageal reflux disease (GERD) during pregnancy. However, there are no reports of the quantification of the absorption of aluminum and magnesium in the antacid magaldrate in women. The aim of this study was to quantify the rate and magnitude of absorption of aluminum and magnesium in magaldrate.

METHODS:

An open-label, controlled, randomized, one-treatment study with a two-group design was conducted in healthy women in a fed state. The volunteers had a standard breakfast, and 30 min later, they were given a single-medication sachet containing 500 mg of sodium alginate, 267 mg of sodium bicarbonate, 800 mg of magaldrate, and 120 mg of simethicone (group A, n = 8) or no medication (group B, n = 2). Blood samples were obtained 36 h before and up to 12 h after antacid administration. The method used for quantification was inductively coupled plasma-mass spectrometry.

RESULTS:

There was no absorption of aluminum in any of the blood samples from the healthy volunteers who received the drug or in those from the control group. Magnesium was detected at normal concentrations.

CONCLUSION:

These findings suggest that the use of this antacid is safe and without risk in healthy women, including pregnant women.

CLINICAL TRIAL REGISTRATION:

Clinicaltrials.gov registration: NCT06367452.

News (Medical) associated with Simethicone

06 Mar 2025

·www.drugs.com

Updates Issued for Optimizing Bowel Preparation Quality for Colonoscopy

THURSDAY, March 6, 2025 -- In updated consensus recommendations published online March 4 in the American Journal of Gastroenterology , additional guidance is presented for optimizing bowel preparation quality for colonoscopy . Brian C. Jacobson, M.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues developed consensus statements and key clinical concepts addressing aspects of bowel preparation for colonoscopy to update the 2014 recommendations for optimizing the adequacy of bowel cleansing. The authors noted that most of the consensus statements focus on individuals at average risk for inadequate bowel preparation; statements are also provided addressing individuals at risk for inadequate bowel preparation quality. Use of a split-dose bowel preparation regimen is recommended; and a 2-liter regimen is suggested as sufficient. For individuals undergoing afternoon colonoscopy, a same-day regimen is recommended as an acceptable alternative; however, for individuals undergoing morning colonoscopy, a same-day regimen is inferior. Dietary restrictions should be limited to the day before a colonoscopy; for early and midday meals, clear liquids or low-fiber/low-residue diets should be relied on. Adjunctive use of oral simethicone is suggested for bowel preparation before colonoscopy. There is also a recommendation for routine tracking of the rate of adequate bowel preparations at the level of individual endoscopists and the endoscopy unit, with a target >90 percent for both rates. "Bowel preparation is a vital part of colonoscopy. If the colon is not adequately cleaned, the person performing the colonoscopy may miss important findings such as small polyps," Jacobson said in a statement. "Many cases end up cancelled when the bowel preparation is inadequate, and that creates tremendous frustration for patients and inefficient use of resources." Several authors disclosed ties to the biopharmaceutical and medical device industries. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

08 Apr 2024

·www.prnewswire.com

Wonderbelly Expands its Suite of Digestive Health Medicines with Launch of Bloat + Gas Relief

AUSTIN, Texas, April 8, 2024 /PRNewswire/ -- Wonderbelly, known for its effective digestive medicine, clean* ingredients and tasty flavors, today announced the launch of its latest product: Wonderbelly Bloat + Gas Relief. The launch marks a considerable milestone in Wonderbelly's goal to become the go-to brand for all things digestive health as the company grows into a second category of digestive medicine. Wonderbelly Bloat + Gas Relief is now available to consumers at Target, on Target.com and Amazon.com. Continue Reading Wonderbelly Expands its Suite of Digestive Health Medicines with Launch of Bloat + Gas Relief Post this Wonderbelly launches Bloat + Gas Relief in two delicious flavors, Strawberry Shortcake and Mango Smoothie. Wonderbelly products offer the same highly effective relief as leading medicine brands with a focus on clean ingredients that are Non-GMO and Clean Label Project Certified. Wonderbelly Bloat + Gas Relief has been expertly formulated to effectively combat symptoms like bloating, gas discomfort, abdominal pressure, and associated fullness. Boasting extra strength with 125mg of Simethicone, the company's new medicine comes in two enticing flavors: Strawberry Shortcake and Mango Smoothie. "From the very beginning, we've been committed to reimagining the digestive health experience so that people can feel good about feeling good. After launching Wonderbelly Antacid last year, we're thrilled to expand into a new digestive category to offer consumers highly effective bloat and gas relief in two delicious flavors we know people will love," says Wonderbelly founder Lucas Kraft. "Ultimately, Bloat + Gas represents a natural progression for Wonderbelly and a direct response to consumer demand for medicine that reflects their modern values. We've worked hard with our retail partners to identify customer needs and are proud to deliver a solution that gives them exactly what they're looking for." Building upon the success of Wonderbelly Antacid, which has rapidly become a consumer favorite with over one thousand five-star reviews, Wonderbelly Bloat + Gas Relief further cements Wonderbelly's role as a trailblazer in the rapidly evolving segment of modern digestive health medicine. "It's great to see Wonderbelly really resonate with consumer demand in the medicine space, particularly with trends towards clean ingredients and more sustainable packaging," says brain-gut expert Emeran Mayer, MD (emeranmayer.com). "I'm excited to continue to support Wonderbelly as they expand their offerings to provide relief for a range of digestive health symptoms." Wonderbelly is committed to using recyclable packaging, with bottles made solely of metal to reduce the use of plastic. Produced by one of the leading OTC manufacturers in the United States, Wonderbelly's products and novel packaging undergo rigorous testing, adhering to the stringent standards set for major pharmaceutical products. Wonderbelly can be found in Target and at retail locations across the country, like Wegmans, Meijer, Kroger, Fred Meyer, Fresh Thyme, Giant Eagle*, Raley's*, Harris Teeter, Central Market, Erewhon, Earth Fare, MOM's Organic. *Wonderbelly defines clean medicine as formulated using pharmaceutical active ingredients with inactive ingredients that are Clean Label Project-Certified, vegan, Non-GMO, and free of artificial dyes, artificial sweeteners, talc, titanium dioxide, parabens, gluten, and dairy. For more information about Wonderbelly, please visit Wonderbelly.com For visual assets, please see Dropbox PR Contact: [email protected] About Wonderbelly Wonderbelly™ is a digestive health medicine company founded by brothers Lucas and Noah Kraft. Wonderbelly makes effective and tasty digestive health medicine free from dyes, artificial sweeteners, talc, titanium dioxide, and genetically modified ingredients. Wonderbelly offers two products, Wonderbelly Antacid™ and Wonderbelly Bloat + Gas Relief™, in an assortment of delicious flavors. The company is committed to using recyclable packaging, including metal bottles and compostable on-the-go pouches, to reduce the use of plastic. SOURCE Wonderbelly

11 May 2021

·www.globenewswire.com

Gastrointestinal Drugs Market Growth Sturdy at 4.9% CAGR to

Pune, India., May 10, 2021 (GLOBE NEWSWIRE) -- Gastrointestinal Drugs Market: Key InsightsAccording to our new research study on “Gastrointestinal Drugs Market to 2027 – Global Analysis and Forecast – by Drug Class, Route of Administration, Application, and Distribution Channel,” the Gastrointestinal Drugs Market Size was valued at US$ 49,043.38 million in 2019 and is projected to reach US$ 71,300.28 million by 2027; it is expected to grow at a CAGR of 4.9% during 2020–2027. The extensive rise in COVID-19 infection fuels growth of the market. However, low awareness associated with gastrointestinal disorders in low-income economies is restricting the market growth. Gastrointestinal Drugs Market: Competition Landscape and Key DevelopmentsSanofi; GlaxoSmithKline plc; Johnson and Johnson Services, Inc.; Bausch Health; AstraZeneca; Takeda Pharmaceutical Company Limited; AbbVie Inc.; Bayer AG; Celltrion Healthcare Co., Ltd.; and Lexicon Pharmaceuticals, Inc. are among the key companies operating in the gastrointestinal drugs market. Leading players are focusing on the expansion and diversification of their market presence and acquisition of new customer base, thereby tapping prevailing business opportunities. In January 2020, AstraZeneca recovered the global rights to brazikumab (formerly MEDI2070), a monoclonal antibody targeting IL23, from Allergan. Brazikumab is currently in a Phase IIb/III program in Crohn’s disease (CD) and a Phase IIb trial in ulcerative colitis (UC). AstraZeneca and Allergan will terminate their existing license agreement and all rights to brazikumab will revert to AstraZeneca. The transaction is expected to complete in the first quarter of 2020. Get Exclusive Sample Pages of Gastrointestinal Drugs Market - COVID-19 Impact and Global Analysis with Strategic Insights at In 2019, North America dominated the global gastrointestinal drugs market. The market growth in the region is attributed to increase in incidence of gastrointestinal diseases due to change in lifestyle, government support for prevention and treatment of gastrointestinal diseases, presence of well-developed healthcare infrastructure, growth of pharmaceutical industry, reimbursement coverage, and industry giants. Moreover, according to the National Health Interview Survey, in 2018, about 14.8 million people in the US were diagnosed with ulcers. Furthermore, the National Ambulatory Medical Care Survey: 2016 reported that around 22.4 million patients visited a physician’s office for digestive diseases, and about 8.3 million emergency department visits were for digestive diseases. Also, US Food and Drug Administration (FDA) approvals in the US are likely to favor the growth of the market. For instance, in May 2020, the US FDA approved Qinlock (ripretinib) tablets as a fourth-line treatment for advanced gastrointestinal stromal tumor (GIST). Furthermore, developments by the market players in this industry is likely to favor market growth. Based on drug class, the gastrointestinal drugs market is segmented into acid neutralizers, antidiarrheal and laxatives, anti-inflammatory drugs, antiemetic and antinauseants, biologics, and others. The acid neutralizers segment held the largest share of the market in 2019. Based on route of administration, the gastrointestinal drugs market is segmented into oral and parenteral. The oral segment held larger share of the market in 2019 and is estimated to register higher CAGR in the market during the forecast period. Based on application, the gastrointestinal drugs market is segmented into inflammatory ulcerative colitis, Crohn's disease, irritable bowel syndrome, gastroenteritis, celiac disease, and others. The inflammatory ulcerative colitis segment held the largest share of the market in 2019. Based on distribution channel, the gastrointestinal drugs market is segmented into hospital pharmacies, retail pharmacies, and online pharmacies. The retail pharmacies segment held the largest share of the market in 2019, and it is estimated to register the highest CAGR in the market during the forecast period. Download Sample PDF Brochure of Gastrointestinal Drugs Market Growth Research Report at The COVID-19 outbreak started in December 2019 in Wuhan (China), and it has spread to ~100 countries across the world, with the World Health Organization (WHO) stating it as a public health emergency. The global impacts of COVID-19 are being felt across several markets. Although the healthcare sector had witnessed SARS, H1N1, and other outbreaks in the last few years, the severity of the COVID-19 has made the situation more complicated due to its mode of transmission. North America has been witnessing a growing number of COVID-19 cases since its outbreak. For instance, according to Worldometer, the number of cases increased to 7,679,908 with 215,039 deaths reported in the US as of October 06, 2020. The cases are also increasing in Mexico and Canada. In Mexico, the cases have reached 761,665, with 79,088 deaths. Similarly, in Canada, there are about 168,960 COVID-19 cases, with 9,504 deaths reported so far. Several companies are cutting their clinical trial activities in response to the COVID-19 pandemic. For instance, slashing clinical trial activity will affect the timelines for Eli Lilly's late-phase trials of mirikizumab in gastrointestinal indications. According to their listings on ClinicalTrials.gov., the phase 3 trials for mirikizumab in Crohn’s disease and ulcerative colitis have primary completion dates ranging from September 2020 to late 2023, which can be a confirmed delay. However, in long run, the demand is expected to increase. For instance, according to the estimates reported by Ironwood Pharmaceutical, the demand for prescription drug product LINZESS—indicated for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation—is expected to increase by 11% from the demand in 2019. Therefore, the growing demand for the constipation treatment in North America in long-term period is likely to boost the growth of the gastrointestinal drugs market. Buy Copy of Gastrointestinal Drugs Market Research Study at Gastrointestinal Drugs Market: Segmental OverviewBased on drug class, the gastrointestinal drugs market is segmented into acid neutralizers, antidiarrheal and laxatives, anti-inflammatory drugs, antiemetic and antinauseants, biologics, and others. The acid neutralizers segment held the largest share of the market in 2019. Antacids are over-the-counter (OTC) medications that neutralize stomach acid and help in relieving heartburn, sour stomach, acid indigestion, and stomach upset. They are available as a liquid or chewable tablet. Some antacids also contain simethicone, an ingredient that helps body in relieving gas. Some antacids contain ingredients that can cause diarrhea, such as magnesium, or constipation, such as aluminum. Based on route of administration, the market is segmented into oral and parenteral. The oral segment held larger share of the market in 2019 and is estimated to register higher CAGR in the market during the forecast period. Based on application, the market is segmented into inflammatory ulcerative colitis, Crohn's disease, irritable bowel syndrome, gastroenteritis, celiac disease, and others. The inflammatory ulcerative colitis segment held the largest share of the market in 2019. Based on distribution channel, the market is segmented into hospital pharmacies, retail pharmacies, and online pharmacies. The retail pharmacies segment held the largest share of the market in 2019 and is estimated to register the highest CAGR in the market during the forecast period. About Us:The Insight Partners is a one stop industry research provider of actionable intelligence. We help our clients in getting solutions to their research requirements through our syndicated and consulting research services. We specialize in industries such as Semiconductor and Electronics, Aerospace and Defense, Automotive and Transportation, Biotechnology, Healthcare IT, Manufacturing and Construction, Medical Device, Technology, Media and Telecommunications, Chemicals and Materials. Contact Us:If you have any queries about this report or if you would like further information, please contact us: Contact Person: Sameer JoshiE-mail: sales@theinsightpartners.comPhone: +1-646-491-9876 Press Release -

AntibodyAcquisition

100 Deals associated with Simethicone

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Abdomen distended	United States	-	01 Jan 1952
Flatulence	United States	-	01 Jan 1952

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Abdominal Pain	Phase 3	Russia	Abbott Laboratories	27 Nov 2020
Irritable Bowel Syndrome	Phase 3	Russia	Abbott Laboratories	27 Nov 2020
Gastrointestinal Hemorrhage	Phase 1	United States	Mayo Clinic	30 Apr 2010

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05951712 (Pubmed \| Indian J Gastroenterol)	Not Applicable	-	800	simethicone (Water)	gabteibtzv(lhxidljxll) = mcpeuxqcwz plyejynkpm (dkopzhoqlo, 9 - 13)	Positive	01 Oct 2024
				Simethicone	gabteibtzv(lhxidljxll) = rcenwvbwzk plyejynkpm (dkopzhoqlo, 6 - 8)
NCT05175131 (CTgov)	Phase 3	Abdominal Pain \| Irritable Bowel Syndrome	465	Simethicone+Mebeverine (Mebeverine+Simethicone Combination)	pryikjuaek(yynctkujmx) = mvmsllrxnw ojpulheeiv (kkvljutlqo, 3.42) View more	-	03 Jan 2024
				Mebeverine (Mebeverine)	pryikjuaek(yynctkujmx) = wppmfzzpkp ojpulheeiv (kkvljutlqo, 3.48) View more
UEGW2023	Not Applicable	-	-	40mg simethicone 20-30 minutes prior to procedure	igqugqzjpz(mzslmfixni) = obbqbdlnhg gztnyopxtq (tfgfbfrids )	-	15 Oct 2023
				40mg simethicone 0-10 minutes prior to procedure	igqugqzjpz(mzslmfixni) = nbpbxbuvgg gztnyopxtq (tfgfbfrids )
PREMEDICATION WITH SIMETHICONE (UEGW2021)	Not Applicable	-	110	Simethicone 200mg	woczfcvsxe(pwdprvzfwq) = kjvcgmrqlj wckiodszvo (igzmwxnoqe ) View more	Positive	02 Oct 2021
				Placebo	woczfcvsxe(pwdprvzfwq) = stgpqtmjru wckiodszvo (igzmwxnoqe ) View more
NCT03119168 (Pubmed \| Gastrointest Endosc)	Phase 4	-	268	Polyethylene glycol plus SIM	acxvmznmvk(nfomsrcpnu) = mgzvsgeewr ubwvlmvtur (svklrsadwq ) View more	-	01 Jul 2019
				Polyethylene glycol	acxvmznmvk(nfomsrcpnu) = zynkqtaaeq ubwvlmvtur (svklrsadwq ) View more
NCT03119168 (CTgov)	Phase 4	Adenoma	268	Simethicone Solution (Simethicone Solution + Polyethylenglycol)	gzlhhsvugl = txmkvulgpc qdrmseydno (imnxsvbuxq, osmemvdzoj - lbylbjztju) View more	-	05 Jun 2019
				Polyethylenglycol (Polyethylenglycol)	gzlhhsvugl = kbckmcgbwt qdrmseydno (imnxsvbuxq, ydbmfzhrne - vczgoxzsnu) View more
NCT02217982 (IIT9, CTgov)	Phase 4	Multiple Sclerosis, Relapsing-Remitting	5	DMF (Control Group)	hzwuorbzzf(etibfeiklp) = gbxwbyssdi ndliefqrga (vzmgkpibjr, etnanancpl - avghwzpwvy) View more	-	06 Jan 2017
				Peanut Butter+Simethicone+Loperamide (Treatment Arm)	hzwuorbzzf(etibfeiklp) = sujsidsmub ndliefqrga (vzmgkpibjr, wzdprbohua - rltjcbecew) View more
NCT01312038 (CTgov)	Phase 2	Functional disorder \| Otitis Media	25	Placebo (Placebo)	lddqifxhxh(rabgnxyapi) = dvnkzsytxs alkjkdjaxw (bnpvyodhgb, 0.34) View more	-	27 Jun 2016
				Simethicone (Simethicone)	iubvzaaezh(hzkxyzwwpy) = gswotmgvlr xbukasbjkq (nkzqrrliao, ztrssvwxlg - eiqkryazzc) View more
NCT02555228 (CTgov)	Phase 2/3	Gastric adenoma	54	Simethicone (Simethicone Premedication)	viwgqdqfog(rnmkateoyh) = weroaspjqh uugfutsoaf (dxkuvwcrfh, 1.65) View more	-	15 Mar 2016
				Water (Placebo)	viwgqdqfog(rnmkateoyh) = rbmkjtvvwi uugfutsoaf (dxkuvwcrfh, 1.97) View more
UEGW2015	Not Applicable	-	-	PEG-Asc	fehrbrgcag(bqvtqlscvb) = PEG-Asc with simethicone caused fewer gastrointestinal symptoms (ex. abdominal fullness, colicky pain, general discomfort) than PEG-Asc gkdqyonjeb (mptxdukasx )	-	01 Oct 2015
				PEG-Asc with simethicone

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