Delving into the Latest Updates on Simethicone with Synapse

UGI endoscopy(esophagogastroduodenoscopy) is the main diagnostic modality for direct visualization ,real time assessment and interpretation of findings encountered. The evaluation of esophagogastroduodenoscopy (EGD) quality measures encompasses several categories, such as structure, procedure, result, and adverse events. The peri-EGD period procedures fall under the procedural area, which is primarily concerned with preventing and minimising missed diagnoses.
. More aid in the identification and characterisation of gastrointestinal mucosal lesions is provided by endoscopes equipped with improved imaging technologies, such as multiband or narrow-band imaging (NBI). Despite these advancements of technological aspects, the unclean mucosal surface of the stomach can make these high-end pieces of equipment virtually useless To visualize properly and diagnose accurately there should be clear visibility of mucus apart from operator experience. Since the stage at diagnosis of upper gastrointestinal cancer is a major factor in survival, early detection is essential in improving the prognosis of patients the main factors responsible for hinderance of mucosal visibility are mucus foam and bubbles, which requires additional care for the clearance to enhance the vision and also decrease endoscopy duration by alleviating the need of repeated flushing and suctioning during endoscopy. The froth and bubbles are made of mucous secretions mixed with gastric juice and bile. Simethicone (polydimethylsiloxane and silicon dioxide) has been proven to be a promising defoaming agent as an endoscopic premedication in removing bubbles . Simethicone works by reducing the surface tension of air bubbles, and releases the trapped air by causing small bubbles to coalesce and collapse . N-acetylcysteine (nac), a mucolytic agent, has also been used as premedication acts by removing the mucous overlying the gastrointestinal mucosa 4-point scale described by Basford et al
1. No adherent mucus and clear views of the mucosa.
2. A thin coating of mucus that did not obscure views of the mucosa.
3. Some mucus/bubbles partially obscuring views of the mucosa (i. E. A small mucosal lesion might be missed without flushing
4. Heavy mucus/bubbles obscuring views of the mucosa (i. E. Extensive flushing is needed to avoid missing small mucosal lesions)

Start Date01 Nov 2024

Sponsor / Collaborator

Asian Institute of Gastroenterology Pvt Ltd.

CTRI/2024/10/074635 / Not yet recruitingPhase 4IIT

Effectiveness of N acetyl cysteine and Simethicone to improve mucosal visibility during GI endoscopy-An interventional study - NA

Start Date09 Oct 2024

Sponsor / Collaborator-

CTRI/2024/06/068842 / Not yet recruitingPhase 3IIT

Efficacy of addition of oral simethicone on the quality of bowel preparation for colonoscopy– a Randomized Controlled Trial - NIL

Start Date30 Jul 2024

Sponsor / Collaborator-

100 Clinical Results associated with Simethicone

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100 Translational Medicine associated with Simethicone

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100 Patents (Medical) associated with Simethicone

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349

Literatures (Medical) associated with Simethicone

01 Nov 2024·ADVANCES IN THERAPY

Evaluation of Aluminum and Magnesium Absorption Following the Oral Administration of an Antacid Suspension Containing Magaldrate in Healthy Women Under Fed Conditions

Article

Author: Burgos Castillo, Maria Juliana ; do Prado Assunção, Leandro ; Arbeláez Quintero, Isaac ; Iorgatchof Xavier, Kamila ; Cruz Palacios, Maria Juliana ; Calafatti Carandina, Silvana Aparecida

INTRODUCTION:

Antacids are commonly used during pregnancy, and they are approved for the relief of symptoms of gastroesophageal reflux disease (GERD) during pregnancy. However, there are no reports of the quantification of the absorption of aluminum and magnesium in the antacid magaldrate in women. The aim of this study was to quantify the rate and magnitude of absorption of aluminum and magnesium in magaldrate.

METHODS:

An open-label, controlled, randomized, one-treatment study with a two-group design was conducted in healthy women in a fed state. The volunteers had a standard breakfast, and 30 min later, they were given a single-medication sachet containing 500 mg of sodium alginate, 267 mg of sodium bicarbonate, 800 mg of magaldrate, and 120 mg of simethicone (group A, n = 8) or no medication (group B, n = 2). Blood samples were obtained 36 h before and up to 12 h after antacid administration. The method used for quantification was inductively coupled plasma-mass spectrometry.

RESULTS:

There was no absorption of aluminum in any of the blood samples from the healthy volunteers who received the drug or in those from the control group. Magnesium was detected at normal concentrations.

CONCLUSION:

These findings suggest that the use of this antacid is safe and without risk in healthy women, including pregnant women.

CLINICAL TRIAL REGISTRATION:

Clinicaltrials.gov registration: NCT06367452.

04 Oct 2024·JOURNAL OF MEDICAL MICROBIOLOGY

Effect of simethicone on the bactericidal efficacy of a high-level disinfectant

Article

Author: Anderson, Gregory G. ; Haugen, Shanil P. ; Sanchez, Anastacia M. ; Weeks, Jon W. ; Pandey, Ruchi ; Segars, Katharine

Introduction. Simethicone is an over-the-counter product that is frequently used by clinicians during endoscopic procedures to reduce foaming and improve visualization. Published studies have found simethicone residue on endoscopes after cleaning and disinfecting the devices as per the manufacturer’s instructions. Some literature suggests that simethicone residue may reduce disinfection efficacy and increase the risk of patient infections.Gap Statement. However, there appears to be a lack of direct evidence in the literature to either disprove this or correlate simethicone presence with an increased microbial risk.Aim: Research was conducted to evaluate the in vitro impact of simethicone on disinfection efficacy.Methodology. Bacteria were grown in a microtitre plate assay in the presence of a range of simethicone concentrations and then treated with a disinfectant. Bacterial growth was assessed by spotting each microtitre well onto an agar plate.Results. The results demonstrated that, under the conditions tested, simethicone did not reduce the efficacy of Cidex ortho-phthalaldehyde disinfectant, which demonstrated at least a 6-log unit reduction in bacterial viability. Additional experiments showed that direct exposure to 66 mg ml−1 of simethicone reduced bacterial viability.Conclusion. These results indicate that simethicone may not reduce the bactericidal efficacy of disinfectant during reprocessing, under certain conditions.

01 Oct 2024·Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Simethicone and N-acetyl cysteine in improving mucosal visibility: Towards a “clearer view” during endoscopy

Letter

Author: Goenka, Mahesh K ; Roy, Akash

1

News (Medical) associated with Simethicone

08 Apr 2024

·www.prnewswire.com

Wonderbelly Expands its Suite of Digestive Health Medicines with Launch of Bloat + Gas Relief

AUSTIN, Texas, April 8, 2024 /PRNewswire/ -- Wonderbelly, known for its effective digestive medicine, clean* ingredients and tasty flavors, today announced the launch of its latest product: Wonderbelly Bloat + Gas Relief. The launch marks a considerable milestone in Wonderbelly's goal to become the go-to brand for all things digestive health as the company grows into a second category of digestive medicine. Wonderbelly Bloat + Gas Relief is now available to consumers at Target, on Target.com and Amazon.com. Continue Reading Wonderbelly Expands its Suite of Digestive Health Medicines with Launch of Bloat + Gas Relief Post this Wonderbelly launches Bloat + Gas Relief in two delicious flavors, Strawberry Shortcake and Mango Smoothie. Wonderbelly products offer the same highly effective relief as leading medicine brands with a focus on clean ingredients that are Non-GMO and Clean Label Project Certified. Wonderbelly Bloat + Gas Relief has been expertly formulated to effectively combat symptoms like bloating, gas discomfort, abdominal pressure, and associated fullness. Boasting extra strength with 125mg of Simethicone, the company's new medicine comes in two enticing flavors: Strawberry Shortcake and Mango Smoothie. "From the very beginning, we've been committed to reimagining the digestive health experience so that people can feel good about feeling good. After launching Wonderbelly Antacid last year, we're thrilled to expand into a new digestive category to offer consumers highly effective bloat and gas relief in two delicious flavors we know people will love," says Wonderbelly founder Lucas Kraft. "Ultimately, Bloat + Gas represents a natural progression for Wonderbelly and a direct response to consumer demand for medicine that reflects their modern values. We've worked hard with our retail partners to identify customer needs and are proud to deliver a solution that gives them exactly what they're looking for." Building upon the success of Wonderbelly Antacid, which has rapidly become a consumer favorite with over one thousand five-star reviews, Wonderbelly Bloat + Gas Relief further cements Wonderbelly's role as a trailblazer in the rapidly evolving segment of modern digestive health medicine. "It's great to see Wonderbelly really resonate with consumer demand in the medicine space, particularly with trends towards clean ingredients and more sustainable packaging," says brain-gut expert Emeran Mayer, MD (emeranmayer.com). "I'm excited to continue to support Wonderbelly as they expand their offerings to provide relief for a range of digestive health symptoms." Wonderbelly is committed to using recyclable packaging, with bottles made solely of metal to reduce the use of plastic. Produced by one of the leading OTC manufacturers in the United States, Wonderbelly's products and novel packaging undergo rigorous testing, adhering to the stringent standards set for major pharmaceutical products. Wonderbelly can be found in Target and at retail locations across the country, like Wegmans, Meijer, Kroger, Fred Meyer, Fresh Thyme, Giant Eagle*, Raley's*, Harris Teeter, Central Market, Erewhon, Earth Fare, MOM's Organic. *Wonderbelly defines clean medicine as formulated using pharmaceutical active ingredients with inactive ingredients that are Clean Label Project-Certified, vegan, Non-GMO, and free of artificial dyes, artificial sweeteners, talc, titanium dioxide, parabens, gluten, and dairy. For more information about Wonderbelly, please visit Wonderbelly.com For visual assets, please see Dropbox PR Contact: [email protected] About Wonderbelly Wonderbelly™ is a digestive health medicine company founded by brothers Lucas and Noah Kraft. Wonderbelly makes effective and tasty digestive health medicine free from dyes, artificial sweeteners, talc, titanium dioxide, and genetically modified ingredients. Wonderbelly offers two products, Wonderbelly Antacid™ and Wonderbelly Bloat + Gas Relief™, in an assortment of delicious flavors. The company is committed to using recyclable packaging, including metal bottles and compostable on-the-go pouches, to reduce the use of plastic. SOURCE Wonderbelly

100 Deals associated with Simethicone

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R&D Status

Approved

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Indication	Country/Location	Organization	Date
Abdomen distended	US	-	01 Jan 1952
Flatulence	US	-	01 Jan 1952

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Abdominal Pain	Phase 3	RU	Abbott Laboratories	27 Nov 2020
Irritable Bowel Syndrome	Phase 3	RU	Abbott Laboratories	27 Nov 2020
Gastrointestinal Hemorrhage	Phase 1	US	Mayo Clinic	30 Apr 2010

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Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05175131 (CTgov)	Phase 3	Abdominal Pain \| Irritable Bowel Syndrome	465	Simethicone+Mebeverine (Mebeverine+Simethicone Combination)	ksivfqzdch(gxqjsjubva) = nmxlmcrqgf znnjkwcevn (arsxnoquvk, vxlzkohkav - nksapblgop) View more	-	03 Jan 2024
				Mebeverine (Mebeverine)	ksivfqzdch(gxqjsjubva) = wwpemmwvdy znnjkwcevn (arsxnoquvk, npgubggdim - bteduumccq) View more
NCT05951712 (Pubmed \| Indian J Gastroenterol)	Not Applicable	-	800	simethicone (Water)	icvayqemnr(uwyfnrhlpi) = rwtjilkihx ehmpultxfu (fcieieqlda, 9 - 13)	Positive	18 Oct 2023
				Simethicone	icvayqemnr(uwyfnrhlpi) = fwueyszcwl ehmpultxfu (fcieieqlda, 6 - 8)
NCT03119168 (CTgov)	Phase 4	Adenoma	268	Simethicone Solution (Simethicone Solution + Polyethylenglycol)	zemwfxwlth(rpefsfgqfx) = qlfjenzihw mwbmogidzo (efwjtslffq, wuxrknnvvj - orspumkmid) View more	-	05 Jun 2019
				Polyethylenglycol (Polyethylenglycol)	zemwfxwlth(rpefsfgqfx) = nlxugqgksd mwbmogidzo (efwjtslffq, jebydhjruj - fqleqlvvku) View more
NCT02217982 (IIT9, CTgov)	Phase 4	Multiple Sclerosis, Relapsing-Remitting	5	Peanut Butter+Simethicone+Loperamide	klixyfvqil(mhwlrvzfjr) = wbprrbgfuy ikaugwqdyf (goaktoaqgp, bpgnsxvacx - unlrgahtbu) View more	-	06 Jan 2017
NCT01312038 (CTgov)	Phase 2	Functional disorder \| Otitis Media	25	Placebo (Placebo)	bhkazmlwum(koprqfzrmw) = sjqvgbixxg rpivgkundl (ckykwatjad, tlywslpkrt - qlbesqzqwm) View more	-	27 Jun 2016
				Simethicone (Simethicone)	pjkcrjfxxp(nyqcfildch) = ersczblfbn broqzacygt (zraohoyluj, laqssluvnd - phgfjpthot) View more
NCT02555228 (CTgov)	Phase 2/3	Gastric mucosal lesion	54	Simethicone (Simethicone Premedication)	ixdptqzdbw(twilolaivj) = fnzobgapcd qpjyaxyuou (vezgedltdc, nomekicstx - ynwefipqcs) View more	-	15 Mar 2016
				Water (Placebo)	ixdptqzdbw(twilolaivj) = kjitgtmlpp qpjyaxyuou (vezgedltdc, yvcesqsgte - ghqeohhtrh) View more
NCT01653171 (Pubmed \| World J Gastroenterol)	Phase 4	-	230	Sodium phosphate plus simethicone	kevahqbqom(veqlomgggy) = cqmadwdjnf cyegxvibfp (qkgjrctgxl ) View more	-	28 Jun 2009
				Sodium phosphate plus placebo	kevahqbqom(veqlomgggy) = eyygpironx cyegxvibfp (qkgjrctgxl ) View more
NCT01653171 (Pubmed \| J Zhejiang Univ Sci B)	Phase 4	Intestinal preparation	230	PEG solution	dxvjhkjgle(vsmpqyyspd) = zupzbficdl klmrosexum (ymsjivdiqe ) View more	-	01 Jan 2009
				PEG solution and simethicone	dxvjhkjgle(vsmpqyyspd) = zsuzsedaft klmrosexum (ymsjivdiqe ) View more