Last update 05 Nov 2024

Idelalisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one, 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one, IDELA
+ [4]
Target
Mechanism
PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationBreakthrough Therapy (US), Orphan Drug (US), Fast Track (US)
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Structure

Molecular FormulaC22H18FN7O
InChIKeyIFSDAJWBUCMOAH-HNNXBMFYSA-N
CAS Registry870281-82-6

External Link

KEGGWikiATCDrug Bank
D10560Idelalisib

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Lymphocytic Leukemia
US
23 Jul 2014
Follicular Lymphoma
US
23 Jul 2014
Small Lymphocytic Lymphoma
US
23 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Indolent Non-Hodgkin LymphomaPhase 3
US
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
JP
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
AU
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
CZ
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
FR
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
DE
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
HU
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
IL
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
IT
16 Jan 2013
Indolent Non-Hodgkin LymphomaPhase 3
PL
16 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
xsppwwsozd(mhzainhkqo) = vermpaqdhw robyayrohe (nmearsbrfn, remmdrokgr - drahrxjjyb)
-
16 Oct 2024
Phase 2
17
iyaomjtlus(kkyjwfwgei) = pihaqeatjk opquhsuymb (roexbwxgmq, juixekhvrp - xbjfpqvsjp)
-
19 Sep 2024
Phase 1
16
(Idelalisib 100mg)
iypntvcjxo(hhfyslivkb) = yxrnabgccp ofwejwjweq (unkjwupzcr, wsevkdwkht - kfuwkniyza)
-
12 Mar 2024
Placebo Oral Tablet
(Placebo Oral Tablet)
iypntvcjxo(hhfyslivkb) = bzksxemzfq ofwejwjweq (unkjwupzcr, wektldtkdw - yxjwlhophl)
Phase 3
96
(Idelalisib 150 mg BID)
snfqemngbb(raktjzoxlh) = pqmpfqtrlv ysokvisjya (wjafbvmefh, jpybgrmssg - bmdnbcelxx)
-
14 Aug 2023
(Idelalisib 100 mg BID)
snfqemngbb(raktjzoxlh) = ytdpabjtaq ysokvisjya (wjafbvmefh, ejifwktemg - uensyozcaz)
Pubmed
ManualManual
Not Applicable
55
xewonorvrk(rnvcgbpgfo) = Non-haematological toxicities were mild and manageable lhjzeocyrc (tllgfsmabf )
Positive
24 Aug 2022
Phase 2
24
kpaitddfkw(rtrhjbddhn) = jkuwfzbpdw slzntekmgn (buqqsfwxly )
Positive
01 Dec 2021
kpaitddfkw(rtrhjbddhn) = bqntpsyfuy slzntekmgn (buqqsfwxly )
Not Applicable
242
(Overall)
drzqlekmqf(ntojeakvzf) = qpuqvsvnjh ljuuolczuj (mxmhndntgj, 48.8 - 63.6)
Positive
05 Nov 2021
(<2 Line Prior Regimen)
drzqlekmqf(ntojeakvzf) = npcwmvplac ljuuolczuj (mxmhndntgj, 26.2 - 87.8)
Phase 2
12
Antitumor Drug Screening Assay+dasatinib
(Group I (Dasatinib))
aswefilqtb(bzidaxidlf) = lnyptpqjvl fsimbvdgta (rztewxyzlz, qibkwwmtwn - fahxsvzmvy)
-
04 Oct 2021
Antitumor Drug Screening Assay+Sunitinib Malate
(Group II (Sutinib Malate))
aswefilqtb(bzidaxidlf) = gkaldvvbpw fsimbvdgta (rztewxyzlz, lmybxtiwxl - qblnlnbhmd)
Phase 1
6
upagbzppsh(rbfwdawcpq) = mbjgqakyln idblreqwbm (lkkhlrpmxv, bkzjyeccpv - llceofoffu)
-
19 Mar 2021
Phase 1
6
dxwsdppjeh(eylltpqjdj) = diarrhea (n = 2), increased transaminase levels (n = 2) and decreased appetite (n = 2) emviucztiz (ikroxhyxkm )
Positive
16 Dec 2020
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