SummaryPhenylephrine, a minuscule molecule drug, exhibits its alpha-1 adrenergic receptor agonist activity, thereby aiding in the dilation of the pupil during ophthalmic exams and procedures. By virtue of its ability to bind with the alpha-1 adrenergic receptors located in the iris dilator muscle, this drug incites constriction of the muscle, thereby instigating the dilation of the pupil. In ophthalmology, this medication is prevalently employed for diagnostic purposes, including examining the retina or measuring intraocular pressure. Phenylephrine Hydrochloride is topically administered in the form of eye drops and exhibits its effect within the window of 10 to 20 minutes, with the dilation persisting for several hours post-administration. |
Drug Type Small molecule drug |
Synonyms (-)-m-hydroxy-α-(methylaminomethyl)benzyl alcohol, fenilefrine, l-(3-Hydroxyphenyl)-N-methylethanolamine + [21] |
Target |
Action agonists |
Mechanism ADRA1 agonists(Adrenergic receptor alpha-1 agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (11 Oct 1954), |
RegulationOrphan Drug (European Union) |
Molecular FormulaC9H14ClNO2 |
InChIKeyOCYSGIYOVXAGKQ-FVGYRXGTSA-N |
CAS Registry61-76-7 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Anesthesia | United States | 21 Oct 2019 | |
Mydriasis | United States | 21 Mar 2013 | |
Hypotension | Japan | 11 Oct 1954 | |
Shock | Japan | 11 Oct 1954 | |
Tachycardia | Japan | 11 Oct 1954 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Fecal Incontinence | Phase 3 | United Kingdom | 01 Feb 2007 | |
Syncope, Vasovagal | Phase 2 | United States | 20 Jul 2021 | |
Hematologic Neoplasms | Phase 2 | United States | 14 May 2015 | |
radiation oral mucositis | Phase 2 | United States | 14 May 2015 | |
Urinary Incontinence | Phase 2 | Israel | 01 Sep 2009 | |
Sexual Dysfunction, Physiological | Phase 1 | United States | 09 Jul 2018 | |
Sexual Dysfunctions, Psychological | Phase 1 | United States | 09 Jul 2018 | |
Mucositis | Phase 1 | United States | 01 Mar 2010 | |
Stomatitis | Phase 1 | United States | 01 Mar 2010 |
Not Applicable | - | - | (Intermittent pneumatic compression (IPC)) | emwsbkgvko(urqebrmspx) = qkkhkichfq bbivhqbepx (nkpgnfnaqj ) | Positive | 01 Nov 2024 | |
(Control (no IPC)) | emwsbkgvko(urqebrmspx) = cgytczirqf bbivhqbepx (nkpgnfnaqj ) | ||||||
EURETINA2024 Manual | Not Applicable | - | 53 | ibkbtcmyzl(zlfgrmffoo) = aavhhjreqt rlvqlnnrol (zamdyezuze ) View more | Positive | 19 Sep 2024 | |
Phase 4 | - | Phenylephrine infusion | klgznkkjxp(xjuorbuyoj) = hrkjhddhdn mcbpyewwai (jsirnvrznz, 3.6 - 5.4) View more | - | 01 Aug 2023 | ||
Phase 1 | - | 36 | lredijtehf(phhzzuwubm) = bhcnmitfds rgevtpksbs (nngejklfaq ) View more | - | 08 Dec 2022 | ||
Phase 4 | Anesthesia Maintenance | 124 | orfuyrypty(ujtikeniob): ARD = -2.4 (95% CI, -4.4 to -0.5) View more | Positive | 24 Oct 2022 | ||
Not Applicable | - | Epinephrine alone | puqbfmkajt(ibroilvenn) = ftbtrdrteo vaefoepmdc (ibwhotwxly ) View more | - | 29 Sep 2022 | ||
Omidria (intracameral phenylephrine and ketorolac) | puqbfmkajt(ibroilvenn) = deggrwqddd vaefoepmdc (ibwhotwxly ) View more | ||||||
Phase 4 | 15 | (Phenylephrine) | ggvnjcsyzx(soikaqqitp) = rzzmjwodva mfsgjvjlmb (mqefeszusf, 0.7) View more | - | 05 Aug 2022 | ||
(Arginine Vasopressin) | ggvnjcsyzx(soikaqqitp) = alkpeocdqi mfsgjvjlmb (mqefeszusf, 0.41) View more | ||||||
Not Applicable | 110 | (Phenylephrine) | uzovkfoptc(txekdkqenp) = hjkdslodqv bgmcdkxqft (mbchmaouhr, .07) View more | - | 02 Jun 2022 | ||
(Ephedrine) | uzovkfoptc(txekdkqenp) = udmtmxavlb bgmcdkxqft (mbchmaouhr, .1) View more | ||||||
Not Applicable | - | Norepinephrine with Phenylephrine | afjtgeqrnb(vrotkkymoa) = tyhcgirvwh qagqxotljs (jfbwpfdhau, 2.6 - 16.2) View more | - | 15 May 2022 | ||
Norepinephrine with Vasopressin | afjtgeqrnb(vrotkkymoa) = yspzzfxzop qagqxotljs (jfbwpfdhau, 1.3 - 12.1) View more | ||||||
Not Applicable | - | Vasoactive Medications (After Protocol Implementation) | gasqpriged(rqhsluejyv) = hnqaabburc deaixujehd (cydhkzymgu ) | - | 15 May 2022 |