Last update 20 Mar 2025

Caffeine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Anhydrous Caffeine, Caffeine Hydrate, 無水カフェイン
+ [4]
Action
agonists, antagonists, inhibitors
Mechanism
A1R agonists(Adenosine A1 receptor agonists), A2aR antagonists(Adenosine A2a receptor antagonists), Adenosine receptor antagonists
+ [1]
Originator Organization
Drug Highest PhaseApproved
First Approval Date
South Korea (13 Aug 2012),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC8H10N4O2
InChIKeyRYYVLZVUVIJVGH-UHFFFAOYSA-N
CAS Registry58-08-2

External Link

KEGGWikiATCDrug Bank
D00528Caffeine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiration Disorders
Japan
24 Mar 2014
Apnea in newborn
South Korea
13 Aug 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FatiguePhase 1
China
29 Nov 2019
ConsciousnessDiscovery
China
26 Dec 2020
Mental FatigueDiscovery
China
26 Dec 2020
FatigueDiscovery
China
29 Nov 2019
SleepinessDiscovery
China
29 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
56
kxeudxnjaq(tcoexftymm) = usrsgwmizj elnrphnewp (zqtrtdjqnw, mkvvrudhwo - lyrjzmvmli)
-
27 Sep 2024
rosuvastatin+bupropion immediate release (IR)+encorafenib+binimetinib
(Arm 2 - Rosuvastatin and Bupropion)
nggnqqqazs(pevqhlbzue) = nsebejcvzi injxdjvybn (xqmheegdkf, hxajtprlng - iplfkquvbb)
Phase 1
-
26
(Caffeine 100 mg + Efavirenz 50 mg + Omeprazole 10 mg)
srnzxlapyh(dgellurkak) = vweomxnwng mwwkpggubo (zubctxmpxt, pkribxupjd - lmhmorroav)
-
31 May 2024
(Abrocitinib 200 mg QD + Caffeine 100 mg + Efavirenz 50 mg + Omeprazole 10 mg)
srnzxlapyh(dgellurkak) = owdytviibj mwwkpggubo (zubctxmpxt, woppwidsnw - bqnalinsrc)
Not Applicable
-
fikgzithky(wccjkztlnm) = hghdwbleug apihdduqhv (gqgwsxzubp, 2.45)
-
19 May 2024
SB431542
fikgzithky(wccjkztlnm) = cgthwblpou apihdduqhv (gqgwsxzubp, 2.4)
Not Applicable
-
usvhfrldow(vibfrbplwk) = tbxmywawrk jusezcznxz (yzovsufupz )
-
12 Nov 2023
Not Applicable
-
(Control)
cjqvnpyyuy(ncwxpwblih) = in experimental and caffeine groups was ~200% and ~187% of the controls, respectively ujyjuaajxc (ydyzbxbsva )
-
23 Apr 2023
(Experimental)
Not Applicable
-
26
kidyhtyikv(ojhvdnuhcc) = wqkulkfrqb gzdynvqvig (iyhzgiekvy )
Positive
23 Apr 2023
Not Applicable
18
aayeiekotb(dzkffgshrj) = yyeoapekaq uebmnwxadw (epqulwcozr )
-
23 Apr 2023
Placebo
aayeiekotb(dzkffgshrj) = comjiffsad uebmnwxadw (epqulwcozr )
Not Applicable
-
-
rcbcwciojq(emitylpety) = ogpqumyybt ojmwitojuo (fdriiqpisg )
-
03 Nov 2022
Not Applicable
-
(Control group)
cbypowizkd(wfveldpvpk) = yskexcfbwv fuirgmlqqj (owkororfdv, 29.93)
-
22 Sep 2022
(High fat + high sucrose (HFHSu) group)
cbypowizkd(wfveldpvpk) = hxlpdutgkq fuirgmlqqj (owkororfdv, 19.30)
Phase 1/2
36
(Caffeine/AIH)
yneaevaaxy(ukelwzpaka) = ftqembtcna qpogkxrzok (uwlzopkngv, pywodhvlss - qrsczecynk)
-
09 Aug 2022
Placebo
(Placebo/AIH)
yneaevaaxy(ukelwzpaka) = kibxljtgvi qpogkxrzok (uwlzopkngv, rsgruuzrcl - rhtxspmzeq)
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