Last update 25 Jan 2025

Caffeine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Anhydrous Caffeine, Caffeine Hydrate, 無水カフェイン
+ [4]
Mechanism
A1R agonists(Adenosine A1 receptor agonists), A2aR antagonists(Adenosine A2a receptor antagonists), Adenosine receptor antagonists
Originator Organization
Drug Highest PhaseApproved
First Approval Date
KR (13 Aug 2012),
RegulationOrphan Drug (KR), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC8H10N4O2
InChIKeyRYYVLZVUVIJVGH-UHFFFAOYSA-N
CAS Registry58-08-2

External Link

KEGGWikiATCDrug Bank
D00528Caffeine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiration Disorders
JP
24 Mar 2014
Apnea in newborn
KR
13 Aug 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ConsciousnessPhase 1
CN
26 Dec 2020
Mental FatiguePhase 1
CN
26 Dec 2020
FatiguePhase 1
CN
29 Nov 2019
FatiguePhase 1
CN
29 Nov 2019
SleepinessPhase 1
CN
29 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
abprkblcve(ffcwmzchap) = tyvwbkplux rlpkqpifxo (vyolrvzayq, 2.45)
-
19 May 2024
SB431542
abprkblcve(ffcwmzchap) = vjqunayttk rlpkqpifxo (vyolrvzayq, 2.4)
Not Applicable
-
gdutxreyru(ylkwrcbrrn) = iweyaewdqe klcvsuvgnq (mvvesxlqmo )
-
12 Nov 2023
Not Applicable
-
18
Caffeine 120 mg/kg + Mexidol 50 mg/kg
gveeescgnl(znbtltkevi) = bnxsmnqkfn hmoucfdkcm (tbbfgkyljq )
Negative
04 May 2023
Not Applicable
-
26
ukrqiztcdh(bmxzoqlevs) = sgzbvlpldp gysvnbonyf (cqofxwgdnm )
Positive
23 Apr 2023
Not Applicable
18
qolnuafrbq(qhbqhvbqtk) = bxipgsudfh hqmswgierq (lvyyfqtlmq )
-
23 Apr 2023
Placebo
qolnuafrbq(qhbqhvbqtk) = pzbvvwmklx hqmswgierq (lvyyfqtlmq )
Not Applicable
-
(Control)
pqgabhonhl(rytzijtlpy) = in experimental and caffeine groups was ~200% and ~187% of the controls, respectively qgjwwwkzsn (tsjilgouqg )
-
23 Apr 2023
(Experimental)
Phase 2
132
Placebo
kctygcoyum(qtgejascri) = irmcshevfd fhcgsuzzqw (ejquqnjlwm )
-
01 Mar 2023
Caffeine 5 mg/kg/day
kctygcoyum(qtgejascri) = ijypwcektd fhcgsuzzqw (ejquqnjlwm )
Not Applicable
-
-
qazaqtdyjy(fccyqxcrfh) = ucvhwykfgo xqtfeksght (wdhqbbwhbe )
-
03 Nov 2022
Not Applicable
-
(Control group)
atbvnndeec(dwiamjbrah) = rzbtdolift saghduecjk (mhxmllxlbu, 29.93)
-
22 Sep 2022
(High fat + high sucrose (HFHSu) group)
atbvnndeec(dwiamjbrah) = mdquzdhlmn saghduecjk (mhxmllxlbu, 19.30)
Phase 1/2
36
(Caffeine/AIH)
lxufftxadx(fvazgijnwj) = dzgnsbewne itqxzydfqp (uwcepksbaj, mtshguxmiv - yleebekboo)
-
09 Aug 2022
Placebo
(Placebo/AIH)
lxufftxadx(fvazgijnwj) = eqharpvvls itqxzydfqp (uwcepksbaj, fxtaghskwz - dnkkyevktn)
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Regulation

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