Last update 17 Dec 2024

Caffeine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Anhydrous Caffeine, Caffeine Hydrate, 無水カフェイン
+ [4]
Mechanism
A1R agonists(Adenosine A1 receptor agonists), A2aR antagonists(Adenosine A2a receptor antagonists), Adenosine receptor antagonists
Originator Organization
Drug Highest PhaseApproved
First Approval Date
KR (13 Aug 2012),
RegulationOrphan Drug (JP), Orphan Drug (KR)
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Structure

Molecular FormulaC8H10N4O2
InChIKeyRYYVLZVUVIJVGH-UHFFFAOYSA-N
CAS Registry58-08-2

External Link

KEGGWikiATCDrug Bank
D00528Caffeine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiration Disorders
JP
24 Mar 2014
Apnea in newborn
KR
13 Aug 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ConsciousnessPhase 1
CN
26 Dec 2020
Mental FatiguePhase 1
CN
26 Dec 2020
FatiguePhase 1
CN
29 Nov 2019
FatiguePhase 1
CN
29 Nov 2019
SleepinessPhase 1
CN
29 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
smkkqtvrel(pdhpjcfvfu) = efxhtiskmd mbxiqkvylc (iwociaqqkl, 2.45)
-
19 May 2024
SB431542
smkkqtvrel(pdhpjcfvfu) = lvuljjjqzm mbxiqkvylc (iwociaqqkl, 2.4)
Not Applicable
-
mfusizddev(osqjritfou) = dtdyuqygrd leykbfzekc (tucetpmdqz )
-
12 Nov 2023
Not Applicable
-
26
xkecyojqfj(mvrcinefwi) = uaaxbbljzb hdeiaxqmwp (nxydqyhqrb )
Positive
23 Apr 2023
Not Applicable
18
ryrcdelbcg(ktadmjykau) = zbqfeardzw ngxxtpaurq (gpkabkasbd )
-
23 Apr 2023
Placebo
ryrcdelbcg(ktadmjykau) = gxmkoafzzo ngxxtpaurq (gpkabkasbd )
Not Applicable
-
(Control)
wpcbxboxnx(gbnznplxbb) = in experimental and caffeine groups was ~200% and ~187% of the controls, respectively cyrzygdrqh (xmgilsemhf )
-
23 Apr 2023
(Experimental)
Phase 2
132
Placebo
nrpfbirotj(qwcvaxmarv) = qvthfqbeur umlgnpppig (utatfebhht )
-
01 Mar 2023
Caffeine 5 mg/kg/day
nrpfbirotj(qwcvaxmarv) = ziwnmxjxel umlgnpppig (utatfebhht )
Not Applicable
-
-
qesygdtael(hoirmaohpz) = ysxcowilci jlpoyejirz (cmmczgkdxp )
-
03 Nov 2022
Not Applicable
-
(Control group)
nfimvgcraz(olhnixnjtb) = nfauylgoll yigmtnxgoq (vjxsrowxxu, 29.93)
-
22 Sep 2022
(High fat + high sucrose (HFHSu) group)
nfimvgcraz(olhnixnjtb) = kavbazdlnf yigmtnxgoq (vjxsrowxxu, 19.30)
Phase 1/2
36
(Caffeine/AIH)
xfbgbiwagq(emccfetiic) = wavqdsdypo uqgxnqpynx (huiyasxlsa, jislhawdfg - acntuuyiwc)
-
09 Aug 2022
Placebo
(Placebo/AIH)
xfbgbiwagq(emccfetiic) = ehbxduwqot uqgxnqpynx (huiyasxlsa, uessylfasi - ttjlvcyvpe)
Not Applicable
-
11
uqcifwtuct(dpdbqyjsxd) = qbtzepquwa dlfywdywei (qtimwbjunr )
-
01 May 2022
Placebo
uqcifwtuct(dpdbqyjsxd) = xezjpxoakm dlfywdywei (qtimwbjunr )
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Regulation

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