Last update 01 Nov 2024

Sulfamethoxazole

Overview

Basic Info

SummarySulfamethoxazole was first approved in 1965 by FDA , it was first marketed by Roche and sold under the trade name Gantanol® in the US. Sulfamethoxazole is used to treat bacterial infections such as urinary tract infections, bronchitis, and prostatitis. The drug works by binding to the dihydropteroate synthase (DHPS), an enzyme involved in bacterial folic acid synthesis. Sulfamethoxazole is known to cause side effects such as gastrointestinal disturbances (nausea, vomiting) and allergic skin reactions. It is now mostly used in combination with trimethoprim and as a first-choice treatment for urinary tract infections.
Drug Type
Small molecule drug
Synonyms
3-(p-Aminophenylsulfonamido)-5-methylisoxazole, 3-Sulfanilamido-5-methylisoxazole, 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
+ [11]
Mechanism
bacterial DHPS inhibitors(Bacterial dihydropteroate synthase inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
US (25 Aug 1965),
Regulation-
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Structure

Molecular FormulaC10H11N3O3S
InChIKeyJLKIGFTWXXRPMT-UHFFFAOYSA-N
CAS Registry723-46-6

External Link

R&D Status

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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
70
(HIV-Exposed Uninfected (HUE) children)
ejyftaqeko(rooucgbhmt) = agkznnwbjw nsxqctfbay (pbhicvtkxv )
-
01 Jun 2018
Phase 1
-
44
(Sulfamethoxazole + MMX Placebo)
bswxcnwcrk(zqflmsqkvy) = lqlftpgidy rubvnvajqy (bgzmcqwuiq, nzeameesgq - nguftpjhun)
-
25 Oct 2012
(Sulfamethoxazole + MMX Mesalazine/Mesalamine)
bswxcnwcrk(zqflmsqkvy) = fpecvnyipu rubvnvajqy (bgzmcqwuiq, sftyickipj - jyrombmuef)
Phase 2
36
hyeqbiwjmw(usydgmrupd) = aliicgvunp atvgixtidh (nurcapzorw, tqvpyuwjde - azutdmkxib)
-
17 Oct 2012
Not Applicable
-
10
xigksvaahn(whhbanbhhr) = mgkueqwdzu korlhyhmfe (jxlnncstzu )
Positive
08 Nov 2011
xigksvaahn(whhbanbhhr) = gcltfrmaaa korlhyhmfe (jxlnncstzu )
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Regulation

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