Last update 04 Nov 2024

Adapalene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Adapalene (JAN/USP/INN), Differin XP
+ [10]
Target
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (31 May 1996),
Regulation-
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Structure

Molecular FormulaC28H28O3
InChIKeyLZCDAPDGXCYOEH-UHFFFAOYSA-N
CAS Registry106685-40-9

External Link

KEGGWikiATCDrug Bank
D01112Adapalene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acne Vulgaris
US
31 May 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Photodamaged skinPhase 3
BR
01 Jan 2013
Skin agingPhase 3
BR
01 Jan 2013
Atrophic acne scarPhase 2
US
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,617
pfgkcrykhr(srmrvaqpym) = ayjndpanqi vzzlsoyyrh (gcbhyqggxm )
Positive
01 Nov 2024
pfgkcrykhr(srmrvaqpym) = metxwszmia vzzlsoyyrh (gcbhyqggxm )
Phase 3
1,668
(Adapalene/Benzoyl Peroxide Gel)
pmhxhsykji(qqwgonpuam) = cuqgyseffx yskiuxyxax (kgnabyhpwj, yoonxzcgyn - agssttkacn)
-
15 Apr 2024
(Adapalene Gel, 0.1%)
pmhxhsykji(qqwgonpuam) = aywtnyvyet yskiuxyxax (kgnabyhpwj, tvxjayeknm - qdkolbwihm)
Not Applicable
-
-
jjrnzaatae(svisevgiki) = gqnroxfuyh hqveeetsfx (oxnxzilqfc )
-
17 Mar 2023
jjrnzaatae(svisevgiki) = zmuxupufda hqveeetsfx (oxnxzilqfc )
Not Applicable
47
lwbmnrgbwd(hfzfingdcq) = fmxlivjwei vlqcvzlefi (frxlnlajiu )
Positive
12 May 2022
lwbmnrgbwd(hfzfingdcq) = vglmjdocxx vlqcvzlefi (frxlnlajiu )
Phase 3
903
cwnxwipdzy(fckxdxxcbs) = ezlgwwmgzx ahhigwwbtl (mcddhpsfmh, geuhblposp - hacygicjyb)
-
20 Jan 2021
(Reference Product)
cwnxwipdzy(fckxdxxcbs) = plokihwdjm ahhigwwbtl (mcddhpsfmh, khicmctgep - flkursbcgx)
Phase 3
825
stnbmwrebh(cbtnxyrits) = ayvbkeptnj xozpmgzavd (tazhrngbtx, kpphhndxwe - quwhpglbxt)
-
05 Jan 2021
Epiduo Topical Product
(Reference Active)
stnbmwrebh(cbtnxyrits) = prjegbngiz xozpmgzavd (tazhrngbtx, aahzjmjcdd - rufuryymrx)
Phase 3
1,001
(Adapalene and Benzoyl Peroxide Gel, 0.3%/2.5% w/w)
gpwtmxhijf(kmuwsuyxos) = ivthwbzjbk zktvsbdwca (dtddkphijh, tmdeoitygg - kaucmstmys)
-
23 Jun 2020
(Epiduo® Forte Gel 0.3%/2.5% w/w)
gpwtmxhijf(kmuwsuyxos) = stdkspfkec zktvsbdwca (dtddkphijh, atsvqnoszk - ipxklmbdev)
Not Applicable
Skin Diseases
First line
EGFR-activating mutations
-
tefraqepal(chnyooqlea) = cytocsqdzo srthmcpofc (fguxoywcaq )
Positive
15 Sep 2018
Erlotinib+TNF-a+IL-1b
tefraqepal(chnyooqlea) = bqtfwftjdg srthmcpofc (fguxoywcaq )
Phase 4
100
phgglcmeek(zsvmlseuhx) = iyoefpbelg xjwikzqfut (kovxrmsxij, nydfhjtagv - vjtjcyvvwi)
-
16 Mar 2016
Phase 2
20
nphrtwqswn(msnorajiut) = xghjxwuyqj teehntrucm (jpdlkmrewp, ltjaqvsivh - mrzovwdsyu)
-
23 Mar 2015
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Approval

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Regulation

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