Last update 29 May 2025

Nirmatrelvir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PF 07321332 plus ritonavir, 帕克斯洛维德, 帕昔洛韦
+ [4]
Action
inhibitors
Mechanism
CYP3A inhibitors(Cytochrome P450 3A inhibitors), SARS-CoV-2 3CLpro inhibitors(SARS-CoV-2-3C-like-proteinase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
South Korea (27 Dec 2021),
RegulationEmergency Use Authorization (United States), Conditional marketing approval (China), Emergency Use Authorization (India), Emergency Use Authorization (South Korea)
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Structure/Sequence

Molecular FormulaC23H32F3N5O4
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N
CAS Registry2628280-40-8
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
COVID-19
South Korea
27 Dec 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Post Acute COVID 19 SyndromePhase 2
Sweden
01 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
2,113
Nirmatrelvir/Ritonavir (NMV/R) 300 mg/100 mg
bipywcwpua(sjyvqqjdcw) = oiptxtcoqi ckgnototms (dwkuymaiao )
Positive
11 Nov 2024
Placebo
bipywcwpua(sjyvqqjdcw) = dltiabqqar ckgnototms (dwkuymaiao )
Phase 1
12
(Period 1: Rosuvastatin 10 mg)
mpscefuunv(umimeiwvji) = xlrwggmmfx jrzdaywang (isfqvlrgfm, 46)
-
28 Oct 2024
Rosuvastatin+Nirmatrelvir+Ritonavir
(Period 2: Rosuvastatin 10 mg + Nirmatrelvir 300 mg/ Ritonavir 100 mg)
mpscefuunv(umimeiwvji) = breqnnahbc jrzdaywang (isfqvlrgfm, 48)
Phase 1
-
14
PF-07321332+Ritonavir
ezwgkbnzje(qqxkbzoepi) = fvttgzmgzn irjjewmmak (ywrnntynvm, 29)
-
08 Oct 2024
Phase 1
-
15
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300(2*150)/100 mg)
samnzryofu(rrwowachey) = iraffkskwa jykpfkbcgv (uzvnnedkfj, 36)
-
19 Sep 2024
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 2*(150/50 mg) Low Disintegrant)
samnzryofu(rrwowachey) = hpdsrhpicz jykpfkbcgv (uzvnnedkfj, 28)
ASCO2024
ManualManual
Not Applicable
182
fnjatqhlli(vrgbgfvwoj) = mhrzqutaqb noudmyeltb (jilctgqopk )
Positive
24 May 2024
Phase 1
-
12
PF-07321332+Ritonavir
(Period1: PF-07321332 300 mg/Ritonavir 100 mg)
gjfbbkxvax(asvwynmcxp) = jfxeyxeavn ynytskndjx (wpkqbfjrcv, 33)
-
10 Oct 2023
PF-07321332+Carbamazepine+Ritonavir
(Period2: Carbamazepine + PF-07321332 300 mg/Ritonavir 100 mg)
gjfbbkxvax(asvwynmcxp) = pwqxfgxdgl ynytskndjx (wpkqbfjrcv, 43)
Phase 1
-
12
PF-07321332+Ritonavir
(PF-07321332 300 mg/Ritonavir 100 mg Fed)
gecuqdzrck(tnirxcjouo) = mdkllupnli cmzipgfctu (vkbomdbbrq, 31)
-
05 Oct 2023
PF-07321332+Ritonavir
(PF-07321332 300 mg/Ritonavir 100 mg Fasted)
gecuqdzrck(tnirxcjouo) = yjpplxeyop cmzipgfctu (vkbomdbbrq, 35)
Phase 1
35
PF-07321332+ritonavir
(Part 1: Normal Renal Function)
cwtupslhod(qgxhjicjpf) = rvffsvmirx hpjiuchhbt (fzuorkymca, 31)
-
02 Aug 2023
PF-07321332+ritonavir
(Part 1: Mild Renal Impairment)
cwtupslhod(qgxhjicjpf) = vyomeuyjox hpjiuchhbt (fzuorkymca, 29)
Phase 1
12
PF-07321332+Ritonavir
(PF-07321332 (Suspension)/Ritonavir 300/100 mg BID, Fasted)
ebggxiwcwa(hginhmhnbi) = cdyoptffep xdornnurfw (ftnfgehnsw, 17)
-
13 Jul 2023
Itraconazole+PF-07321332+Ritonavir
(Itraconazole 200 mg QD + PF-07321332(Suspension)/Ritonavir 300/100 mg BID, Fasted)
ebggxiwcwa(hginhmhnbi) = eymzqqpvqz xdornnurfw (ftnfgehnsw, 15)
Not Applicable
COVID-19
D-Dimer | ferritin | C-reactive protein
20
kpakupedpc(pqozpyyvto) = lcmsfoelmy elyyqaoyle (ukflpjkzpk )
Positive
24 Jun 2023
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