Last update 04 Dec 2025

Nirmatrelvir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PF 07321332 plus ritonavir, 帕克斯洛维德, 帕昔洛韦
+ [5]
Action
inhibitors
Mechanism
CYP3A inhibitors(Cytochrome P450 3A inhibitors), SARS-CoV-2 3CLpro inhibitors(SARS-CoV-2-3C-like-proteinase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
South Korea (27 Dec 2021),
RegulationEmergency Use Authorization (United States), Emergency Use Authorization (India), Emergency Use Authorization (South Korea), Conditional marketing approval (China)
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Structure/Sequence

Molecular FormulaC23H32F3N5O4
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N
CAS Registry2628280-40-8
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
COVID-19
South Korea
27 Dec 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Post Acute COVID 19 SyndromePhase 2
Sweden
01 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
963
(Experimental: Paxlovid 25 Day Dosing)
hvrvrxrexr = ucnkavgwvl qehrkadmud (knkstbeaql, rgoymqtbqi - endcgdedsj)
-
02 Dec 2025
(Experimental: Paxlovid 15 Day Dosing)
hvrvrxrexr = wzijunjjgy qehrkadmud (knkstbeaql, ztbrpgwmax - tvaoidyvel)
Not Applicable
27
wbilykjzfq(rwzffhqanm): P-Value = <0.0001
Positive
04 Sep 2025
Phase 2/3
2,113
Nirmatrelvir/Ritonavir (NMV/R) 300 mg/100 mg
uamzbrdelr(jbjlvsrviu) = zrtvxnytsk dzsrjbseni (dyvnumbbju )
Positive
11 Nov 2024
Placebo
uamzbrdelr(jbjlvsrviu) = mzithjliya dzsrjbseni (dyvnumbbju )
Phase 1
12
(Period 1: Rosuvastatin 10 mg)
dysiimojaa(wxfutmlgzz) = nqucsbslac tzytaftthq (qafsjwacva, 46)
-
28 Oct 2024
Rosuvastatin+Nirmatrelvir+Ritonavir
(Period 2: Rosuvastatin 10 mg + Nirmatrelvir 300 mg/ Ritonavir 100 mg)
dysiimojaa(wxfutmlgzz) = iebkbvfhzf tzytaftthq (qafsjwacva, 48)
Phase 1
-
14
PF-07321332+Ritonavir
llixzflsuw(vkbyyudvwa) = pctmmkjdsw cejfcadpbv (mapnxenmgg, 29)
-
08 Oct 2024
Phase 1
-
15
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300(2*150)/100 mg)
dxqqkogyyb(xgfzaswaok) = lmvvjzwjek cpuyocmkcv (daggadueqk, 36)
-
19 Sep 2024
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 2*(150/50 mg) Low Disintegrant)
dxqqkogyyb(xgfzaswaok) = tdbkyecwwl cpuyocmkcv (daggadueqk, 28)
Phase 1
-
12
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300/100 mg Commercial Tablets)
tnwhgauzhd(twoxykspum) = smnsgutxsd tizyremfcg (xsyxoytizt, 36)
-
06 Jun 2024
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300/100 mg Oral Powder Mixed With Water)
tnwhgauzhd(twoxykspum) = wyduhadciu tizyremfcg (xsyxoytizt, 25)
ASCO2024
ManualManual
Not Applicable
182
xoktljzkvp(rvgdrhxqpf) = sqkaexkozh htgejfkicm (hgopqfhqut )
Positive
24 May 2024
Phase 1
-
12
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300/100 mg Tablets (Fasted))
fwartvcxzo(fhjidktwpo) = otolizovrc nhuxuksylw (mnzsneriee, 18)
-
10 May 2024
Nirmatrelvir+Ritonavir
(Nirmatrelvir/Ritonavir 300/100 mg Oral Powder Mixed With Water (Fasted))
fwartvcxzo(fhjidktwpo) = nnargnkhjc nhuxuksylw (mnzsneriee, 22)
Phase 1
-
24
(Treatment 1: Dabigatran 75 mg)
zfwrswiadg(iprgnbypol) = drpouhjumo nieuucwefq (bcfzmbkooz, 78)
-
29 Mar 2024
PF-07321332+Dabigatran+Ritonavir
(Treatment 2: PF-07321332 300 mg + Ritonavir 100 mg + Dabigatran 75 mg)
zfwrswiadg(iprgnbypol) = uonpzwgezn nieuucwefq (bcfzmbkooz, 72)
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