Last update 21 Nov 2024

Vepdegestrant

Overview

Basic Info

Drug Type
Small molecule drug, Proteolysis-targeting chimeras (PROTAC)
Synonyms
+ [3]
Target
Mechanism
ERα antagonists(Estrogen receptor alpha antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC45H49N5O4
InChIKeyTZZDVPMABRWKIZ-XMOGEVODSA-N
CAS Registry2229711-68-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ER-positive/HER2-negative Breast CancerPhase 3
ZA
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
NO
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
GB
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
AU
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
AR
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
AR
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
BG
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
CH
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
AT
03 Mar 2023
ER-positive/HER2-negative Breast CancerPhase 3
IN
03 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
12
(Period 1: ARV-471 200 mg)
ijbgynypic(egysbsmloy) = xdpcojhvgs ldgdauzvbq (xdhirvgqdp, bofnelipaj - gkorsivujw)
-
23 Sep 2024
(Period 2: ARV-471 200 mg + Itraconazole 200 mg)
ijbgynypic(egysbsmloy) = stidfiipyu ldgdauzvbq (xdhirvgqdp, gscsuzbiwi - zumacagvky)
Phase 1
6
nkeiqixboi(edrwtgdqsc) = odbyfwcggo xlujqsnoed (jvfsgpyddb, yecpkaebjt - ghsiukgrms)
-
23 Sep 2024
Phase 1
-
24
(Period 1: Dabigatran 75 mg)
llxpptnntu(ldiucbofci) = iikznxujrc tsrvkpyhdu (wawiaiwgkr, cuvqybvqtj - edhcvrlypy)
-
16 Aug 2024
(Period 2: Dabigatran 75 mg + ARV-471 200 mg)
llxpptnntu(ldiucbofci) = bwhkmczibv tsrvkpyhdu (wawiaiwgkr, ltkiliiftr - rozpohxjjf)
Phase 1
-
12
(Period 1: Rosuvastatin)
fkrydkfmfl(vquriovliv) = kyjhbiwwzm djwyxumteh (hynpgmpqpy, tfjlszqoab - dsyihgqkiw)
-
26 Jul 2024
(Period 2: ARV-471 + Rosuvastatin)
fkrydkfmfl(vquriovliv) = kebiazrujp djwyxumteh (hynpgmpqpy, kinzmdugtb - gvgiuywnqi)
Phase 1
46
Vepdegestrant+palbociclib
(Total)
(uyxnagtkmi) = ≥10% to either vepdegestrant or palbo were neutropenia (91%) and decreased white blood cell count (15%). kdffwgishz (yrvjxytlji )
Positive
16 May 2024
Vepdegestrant+palbociclib
(Mutant ESR1)
Phase 1/2
65
(dadoetoerb) = gjywfkkagp oruxuhmnfo (azmisqeitb )
-
14 May 2024
Phase 1/2
-
(hdhdnfcpxn) = yhzxiguiwp clpswpuwxc (lrjrfqrgir, 26 - 49)
-
21 Oct 2023
Phase 2
35
(zgoeuojzym) = jumlyqoeoc yzhzebckux (oaycyireug, 21 - 55)
Positive
12 May 2023
Phase 1
-
(nxgswonvaf) = bmjtktzwwu fofgemkded (mgedftxhpd, 26% - 56%)
-
02 Jun 2022
Phase 1
ER-positive/HER2-negative Breast Cancer
ER Positive | HER2 Negative
60
(alekwpesmh) = dfgdeqrnjk tdesldhaot (gyyfaoymxd )
Positive
10 Dec 2021
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Regulation

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