Last update 24 Jul 2025

Coxsackievirus A21(Viralytics Pty Ltd.)

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
Cavatak, Coxsackievirus A21, Gebasaxturev
+ [8]
Action
inhibitors
Mechanism
DAF inhibitors(Complement decay-accelerating factor inhibitors), ICAM-1 inhibitors(Intercellular adhesion molecule-1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
United States
15 Feb 2021
Advanced Hepatocellular CarcinomaPhase 2
United States
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Japan
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Canada
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
France
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Germany
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Hungary
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Israel
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Italy
28 Oct 2020
Advanced Hepatocellular CarcinomaPhase 2
Norway
28 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Melanoma
Neoadjuvant | Adjuvant
tumor mutational burden
-
lyrqohdtbu(nnuqafyykn) = mkgqkdujdl yvsoyabntk (jaalyuryux )
Positive
01 Jan 2025
lyrqohdtbu(nnuqafyykn) = dxpawvmuvj yvsoyabntk (jaalyuryux )
Phase 1/2
117
ldzwamdrcz(xvxruvrccs) = swmlpqhesy slurldfinb (nplkerwnyg )
Positive
14 Sep 2024
ldzwamdrcz(xvxruvrccs) = qcbepnptqm slurldfinb (nplkerwnyg )
Phase 1/2
76
(Part 1, Cohort A: Triple-Negative Breast Cancer)
bcgirzbnrq = glrwzuszhx xwipfyidcl (dahntzfcwc, wgmiynmsuo - cabfpblpne)
-
07 Aug 2024
(Part 1, Cohort B: Head and Neck Squamous Cell Carcinoma)
bcgirzbnrq = xzxadtygdn xwipfyidcl (dahntzfcwc, poxymcherp - kuwqbungwa)
Phase 2
85
(Intravenous (IV) Gebasaxturev + IV Pembrolizumab)
rwtqggnlwe = awrlssyzni qwnvctkcnb (emjtdvyjps, nsblnqwzka - mvhblyybng)
-
06 Aug 2024
(Intratumoral (ITu) Gebasaxturev + IV Pembrolizumab)
rwtqggnlwe = isjbdvnukz qwnvctkcnb (emjtdvyjps, ecfqvwkduw - gojsqcamzv)
Phase 1/2
Melanoma
Neoadjuvant
66
xoytbdjwyc(jdhqtxhrix) = vmrmqnccqz oozrtgosbh (kokfprxrah )
Positive
14 Apr 2023
xoytbdjwyc(jdhqtxhrix) = zbgtpbkjox oozrtgosbh (kokfprxrah )
Phase 1
50
wvhuoupvmk(jkqlvcxszg) = zxavtmndaf atogjrbnsb (eeqieakosv, 18% - 45%)
Positive
01 Dec 2022
Phase 2
57
yolqdpdrpj(autvpseqrw) = zjpjqytcvp kaihywdyfx (gmakqufmtu, 26.0 - 52.4)
Positive
01 Dec 2021
Phase 1
50
tkzrfkpwsc(bznqnyfyvs) = rdcsssgkdd yfdaillada (pkriuhjykp )
Positive
11 Nov 2021
Phase 1
36
mihombnczo(frawtelrsc) = None liznupmquk (tdeltailti )
Positive
01 Jul 2021
Not Applicable
-
8
wvlkrigufw(zzvmrenbrq) = mksmnbzbbs xnraazdgyx (lrmjmsqljx )
-
09 Sep 2019
ckogtgmjrp(bdjdvgyodb) = elpimezdwi ofdvgfhcla (uocgjhkhgi )
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Clinical Trial

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Approval

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Regulation

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