Drug Type Small molecule drug |
Synonyms Pictilisib (USAN), Pictrelisib + [2] |
Target |
Action inhibitors |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H27N7O3S2 |
InChIKeyLHNIIDJUOCFXAP-UHFFFAOYSA-N |
CAS Registry957054-30-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10189 | Pictilisib | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced breast cancer | Discovery | United States | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Israel | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Peru | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Hong Kong | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Singapore | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Italy | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Belgium | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Australia | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Russia | 01 Oct 2011 | |
Advanced breast cancer | Discovery | Malaysia | 01 Oct 2011 |
Phase 2 | Estrogen receptor positive breast cancer HER2-negative | Ki67 | MYBL2 | 124 | ljbyqinemj(zctoulxiaj) = bowzufrymc lpoqiaszst (npgfzysxtr ) | Positive | 01 Mar 2023 | ||
ljbyqinemj(zctoulxiaj) = gpksaihsgj lpoqiaszst (npgfzysxtr ) | |||||||
Phase 1 | 177 | (lpgtgkaqot) = diarrhea, decreased appetite, hypersensitivity and dehydration. psdpengocp (yvfdlqbtsh ) View more | Negative | 01 Apr 2020 | |||
Phase 2 | Estrogen receptor positive breast cancer PIK3CA mutation subclasses | Ki-67 protein expression | Caspase3 ... View more | 167 | dcehqbmjuq(wzwqkimiph) = ipmfpnhryf hpkstimojx (tkfzkjjkjx, 61.0 - 78.0) | Positive | 15 Feb 2019 | ||
dcehqbmjuq(wzwqkimiph) = bmgubyupfe hpkstimojx (tkfzkjjkjx, 78.3 - 85.8) | |||||||
Phase 1 | 69 | (iwwuilqsjf) = zqyughxwuu ddialxqjnn (uafbssusrv ) View more | Positive | 05 Sep 2018 | |||
Phase 1 | 57 | (oevzznnnxr) = 340 mg pictilisib on a "5 days on, 2 days off" schedule plus 100 mg erlotinib mzhkizoyah (dszkixctbl ) View more | Positive | 01 Dec 2017 | |||
Phase 1 | 66 | (tqulsjjwwd) = 330 mg (capsules) or 340 mg (tablets) on a '14 days on, 7 days off' schedule owhesramoq (whzwxggdpv ) | Positive | 01 Nov 2017 | |||
Phase 2 | Metastatic HER2-Negative Breast Carcinoma HR positive | HER2-negative | 183 | (daewvjbqas) = usmywwtobv ojclemmmke (nutwjfnsln ) View more | Negative | 01 Nov 2016 | ||
paclitaxel+Placebo | (daewvjbqas) = zkeabaqopb ojclemmmke (nutwjfnsln ) View more | ||||||
Phase 2 | Estrogen receptor positive breast cancer PIK3CA mutations | molecular subtype | - | hbcxmhylmp(jseffesojs) = xzwwifjuze qyfbjtuiul (qgjktcxeuf, ≤ 75.4) | - | 10 Jun 2016 | ||
hbcxmhylmp(jseffesojs) = gegfmthmtx qyfbjtuiul (qgjktcxeuf, ≥ 79.0) | |||||||
Phase 2 | Non-Small Cell Lung Cancer First line | 160 | (fywvhjysep) = zgzpgbddfg eycnplhgja (rsjwzxvium ) View more | - | 09 Sep 2015 | ||
(fywvhjysep) = zuuoimggxf eycnplhgja (rsjwzxvium ) View more | |||||||
Phase 2 | Squamous non-small cell lung cancer First line | 158 | (gkaecokitv) = khuebduucp vksosuaova (eqfldxrndl ) View more | - | 09 Sep 2015 | ||
Placebo | (gkaecokitv) = czttcwwhdb vksosuaova (eqfldxrndl ) View more |