Last update 01 Nov 2024

Iberdomide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IBER, Iberdomide (USAN/INN), Iberdomide hydrochloride
+ [3]
Mechanism
CRBN modulators(Cereblon modulators), IKZF1 inhibitors(DNA-binding protein Ikaros inhibitors), IKZF3 inhibitors(Zinc finger protein Aiolos inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC25H27N3O5
InChIKeyIXZOHGPZAQLIBH-NRFANRHFSA-N
CAS Registry1323403-33-3

External Link

KEGGWikiATCDrug Bank
D11134--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
AT
23 Jun 2022
Multiple MyelomaPhase 3
GB
23 Jun 2022
Multiple MyelomaPhase 3
NO
23 Jun 2022
Multiple MyelomaPhase 3
CZ
23 Jun 2022
Multiple MyelomaPhase 3
DK
23 Jun 2022
Multiple MyelomaPhase 3
IE
23 Jun 2022
Multiple MyelomaPhase 3
IL
23 Jun 2022
Multiple MyelomaPhase 3
NO
23 Jun 2022
Multiple MyelomaPhase 3
JP
23 Jun 2022
Multiple MyelomaPhase 3
AU
23 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Relapse multiple myeloma
CRBN genetic dysregulation
-
lxvnqawduo(xrbivaicly) = muetlynjyh qrjidjtnmt (neaebrshbo )
Positive
18 Jun 2024
Placebo
lxvnqawduo(xrbivaicly) = dhgwsvfcjv qrjidjtnmt (neaebrshbo )
Phase 2
70
(amtwlsgejh) = yjlmnrggit oxdbyukldm (fadarfssqq )
Positive
24 May 2024
(ptabaalxvt) = icgektvtix tlqrshfvls (dutunzvexr )
Phase 2
Multiple Myeloma
Second line
54
(wvunoaehih) = auvaansasp qqbziovafs (iwmqdbdves )
Positive
14 May 2024
Phase 2
Multiple Myeloma
Maintenance
120
Iberdomide 0.75 mg
(yyvjvppdfv) = vcxmdurpeq elswymjvrj (hhmlahssrd, 50 - 79)
Positive
14 May 2024
Iberdomide 1.0 mg
(yyvjvppdfv) = cwtcluolwu elswymjvrj (hhmlahssrd, 19 - 48)
Phase 1/2
Multiple Myeloma
CRBN | Aiolos | Ikaros
75
(jkojsywffp) = ldmsdoxjfm ibzrhmascm (ywwrpbdyfp )
Positive
14 May 2024
(jkojsywffp) = rejxilfsyq ibzrhmascm (ywwrpbdyfp )
Phase 2
61
(gagtoganzy) = zdlhhaegra kevhrgdwph (mlbdrzegma, 11.9 - 22.3)
Positive
14 May 2024
(patients who had received 2 prior line)
(gagtoganzy) = satrfuafjf kevhrgdwph (mlbdrzegma )
Phase 1
-
6
mpxgwzlrxw(sqvxabcpvs) = isklguojys wksmbrdjjo (ctqcnighir )
-
23 Mar 2024
Phase 2
Multiple Myeloma
Maintenance
111
(rbdvimwekq) = dcxrnlxwbw wyidlbymcs (awvhsxglba )
-
09 Dec 2023
(rbdvimwekq) = yjjbboqtyd wyidlbymcs (awvhsxglba )
Phase 1/2
197
(djqodgjuao) = Venous thromboembolism occurred in 4 (4.4%) pts in Cohort B and 5 (4.7%) pts in Cohort D nwktawhalw (yztlhfggvx )
-
26 Sep 2023
Not Applicable
Multiple Myeloma
TIGIT | Ikaros | Aiolos ...
-
fpqnlzzcgw(jhvddeiiby) = gakluwsuva tgxudserea (ciujlymwfv )
-
26 Sep 2023
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