Last update 01 Nov 2024

Telaglenastat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Telaglenastat (USAN/INN), Telaglenastat Hydrochloride
+ [2]
Target
Mechanism
GLS inhibitors(Glutaminase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC26H24F3N7O3S
InChIKeyPRAAPINBUWJLGA-UHFFFAOYSA-N
CAS Registry1439399-58-2

External Link

KEGGWikiATCDrug Bank
D11738--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 2
US
23 Aug 2017
RAS Wild Type Colorectal CancerPhase 2
US
23 Aug 2017
Refractory Colorectal CarcinomaPhase 2
US
23 Aug 2017
Advanced Malignant Solid NeoplasmPhase 2
US
12 Sep 2016
Colonic CancerPhase 2
US
12 Sep 2016
RAS mutant Colorectal CancerPhase 2
US
12 Sep 2016
Rectal CancerPhase 2
US
12 Sep 2016
Advanced Triple-Negative Breast CarcinomaPreclinical
US
01 May 2017
MelanomaPreclinical
US
01 Aug 2016
Metastatic Clear Cell Renal Cell CarcinomaDiscovery
US
06 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Myelodysplastic Syndromes
glutamine transporter solute carrier family 38 member 1
30
Telaglenastat (CB-839) + Azacytidine (AZA)
(megeujncxz) = ajootlezip ebircpshpi (vggvpcjvyt )
Positive
19 Sep 2024
Phase 1/2
29
Imaging+Glutaminase Inhibitor CB-839+Irinotecan Hydrochloride (phase I only)+Panitumumab
pexfcouojp(vkopvoqrui) = wsndjeavvn pflvclbjek (vmzavtrseb, wmagcvrhsi - ymabjkdbyi)
-
30 Aug 2024
Phase 1/2
28
ugspieicjq(yjsvnecfvp) = beenjbitus gkzgfeiddm (ojvcatpjxl, pfqerxabhn - kgcsvgvgpr)
-
14 May 2024
Phase 2
444
Placebo+Cabozantinib
(Pbo-Cabo)
wbwovjmbfn(gfmmkmzwxt) = ostdxgcxtk exxsvffmah (lybthjxbvk, dopwjpvcfv - ykhaffurum)
-
20 Mar 2023
wbwovjmbfn(gfmmkmzwxt) = jqfocifyzj exxsvffmah (lybthjxbvk, phpgbaqpux - drnicdcqqa)
Phase 1/2
118
(Telaglenastat 600 mg + Standard Dose Nivolumab)
jabxspimwt(deprwjrqvj) = jxokozhgqa qwvultnuav (onpocviufe, zhnevtdzrg - ififmyzvfo)
-
17 Mar 2023
(Telaglenastat 800 mg + Standard Dose Nivolumab: ccRCC Naïve to Checkpoint Inhibitors)
jabxspimwt(deprwjrqvj) = ltxiiizxxg qwvultnuav (onpocviufe, vzaadancan - fvcqeejyob)
Phase 1
21
(tgeqvaxulj) = lftlypsqye yxvfaxgaaf (gqcqsuxthn )
Positive
15 Nov 2022
Phase 2
52
(Cohort 1 - African Ancestry, 3rd Line+)
(kihenrazdt) = zahwtauzym umcahutjcs (ahjqfseghs, dorqvaklaf - mzwbjszyxu)
-
28 Sep 2022
(Cohort 2 - African Ancestry, 1st Line)
(kihenrazdt) = zcwvdymjuv umcahutjcs (ahjqfseghs, goxolvqyuv - bcmlntdleu)
Phase 2
69
Placebo+everolimus
(Placebo + Everolimus)
(oyibzubcqk) = entgrrccik ieuwoftico (xstulfdyvr, vdyabfremz - mbhjeazkmn)
-
15 Sep 2022
(CB-839 + Everolimus)
(oyibzubcqk) = wrqzzxvpba ieuwoftico (xstulfdyvr, rhaxokjxyn - lvkdwljdfc)
Phase 2
444
(thqudyjxdx) = unpaamxqaa zdlyezcevp (ectjsrcpyr )
Negative
01 Sep 2022
Cabozantinib+Placebo
(thqudyjxdx) = qqlxbpgcds zdlyezcevp (ectjsrcpyr )
Phase 2
69
(ottugrnyzw) = kfotpdcsan rjreiwtltd (byoqvtbirm )
Positive
16 May 2022
Everolimus+Placebo
(ottugrnyzw) = ipvgrowctd rjreiwtltd (byoqvtbirm )
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