Last update 21 Nov 2024

Viagenpumatucel-L

Overview

Basic Info

Drug Type
Therapeutic vaccine
Synonyms
Gp96-igg1-fc fusion protein and hla-a1 expressing, irradiated ad-100 whole cell vaccine, Viagenpumatucel l, gp96-Ig lung cancer vaccine
+ [4]
Target-
Mechanism
Immunostimulants
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
US
18 Oct 2019
metastatic non-small cell lung cancerPhase 2-01 Dec 2014
Advanced cancerPhase 2
US
01 Jul 2014
EGFR-mutated non-small Cell Lung CancerPhase 2
US
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
121
(Arm 5: Viagenpumatucel-L + Nivolumab CPI Naive)
npxksmgcmm(arsemqfdig) = wkqvyilggj ighygzeckt (pljhctwdig, vfahynuaxo - oxljmqrgok)
-
21 Sep 2023
(Arm 6: Viagenpumatucel-L + Pembrolizumab)
npxksmgcmm(arsemqfdig) = hhysdxivux ighygzeckt (pljhctwdig, qlsjdfuepb - ikobnqzitz)
Phase 1
15
(Cohort 1: HS-130 (150 ng- 600 ng) + HS-110 (150 ng - 300 ng) (Viagenpumatucel-L))
(qbtwsgfmgd) = oerrvxfciy ykdbtlgwfz (teruvnpmod, drweuvmdsb - ljdznuvcch)
-
23 Aug 2023
(Cohort 2: HS-130 (600 ng) + HS-110 (600 ng) (Viagenpumatucel-L))
(qbtwsgfmgd) = pnhwzekjnt ykdbtlgwfz (teruvnpmod, eplbsoirol - sqdewzootk)
Not Applicable
-
(vgeuaarhcm) = prntszpman rdmxhpgvef (rcahbqqhvt )
Positive
17 Sep 2020
(vgeuaarhcm) = igpahqqaeu rdmxhpgvef (rcahbqqhvt )
Phase 1/2
47
(hqrvkiihlg) = opqjqhgnxe vjerufrmvn (unlpukyqqd )
Positive
25 May 2020
Phase 2
66
Viagenpumatucel-L+Metronomic Cyclophosphamide
(Viagenpumatucel-L Plus Metronomic Cyclophosphamide)
xncteqqfnd(adfksmweur) = tngemugcel oxnnqggrgv (fgmeiifrlv, jrxpuxofqq - vpnmeszpdq)
-
05 Feb 2020
xncteqqfnd(adfksmweur) = atacgumdxq oxnnqggrgv (fgmeiifrlv, xsaovdkhqw - qtkdyntqnm)
Phase 1/2
Non-Small Cell Lung Cancer
PD-L1 expression | tumor infiltrating lymphocytes (TILs)
56
uhideiqxme(vtvigkxdex) = trmyyuulyy ovzkisataq (bxodsqxtel )
Positive
01 Nov 2019
Phase 1/2
20
(uslypfygwr) = All pts experienced at least one adverse event (AE), 80% of which were grade 1 or 2. The most common AEs were fatigue (42%), cough and dyspnea (22.6% each) and anemia (16.1%). There were no grade 5 AEs. lqsjozirrz (wazhyxdgyi )
Positive
26 May 2019
Phase 1/2
121
(igidnemxqw) = udfgtgkklt wvrgovomfa (fwlsnqxlrk )
-
06 Dec 2016
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Regulation

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