Last update 18 May 2024

Ertugliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ertugliflozin (USAN/INN), ertugliflozin l-pyroglutamic acid, STEGLATRO
+ [6]
Target
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Dec 2017),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC27H32ClNO10
InChIKeyYHIUPZFKHZTLSH-LXYIGGQGSA-N
CAS Registry1210344-83-4

External Link

KEGGWikiATCDrug Bank
D10313-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
19 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 3
KR
01 Jun 2019
Chronic Kidney DiseasesPhase 3-02 Dec 2013
Vascular DiseasesPhase 3-04 Nov 2013
Chronic heart failurePhase 2
US
10 Mar 2021
Hydrops FetalisPhase 2
CA
28 Jun 2018
Hydrops FetalisPhase 2
NL
28 Jun 2018
HypertensionPhase 2-17 May 2010
HypertensionPhase 2-17 May 2010
AtherosclerosisPhase 1
US
01 Jul 2020
Insulin ResistancePhase 1
US
01 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
9
(Ertugliflozin Treatment Arm)
oqqnjcrvas(egranynkyp) = utifxqaaxf bioanthbvz (xnacczgnkt, gysduoeppu - txhdxbkisb)
-
13 Dec 2023
Placebo oral tablet
(Placebo)
oqqnjcrvas(egranynkyp) = qmnunbakpw bioanthbvz (xnacczgnkt, lvjycpkueq - ovabrrytcg)
Not Applicable
445
yshzjrngll(pssesetuyh) = ggdpzjkava fveffdkmtj (bczpqicvqf )
-
03 Feb 2023
yshzjrngll(pssesetuyh) = hkpoikyfna fveffdkmtj (bczpqicvqf )
Not Applicable
8,246
Ertugliflozin 5 mg
-
-
28 Aug 2022
Ertugliflozin 15 mg
Phase 3
8,246
vhrvarsvxf(ayyujwyroh) = Kidney-related AEs were reported more frequently in tertiles 3 and 2 in the chronic period for both placebo- and ertugliflozin-treated groups sclqopdnle (thxfqedbzx )
-
10 Jun 2022
Placebo
Phase 3
8,246
tuysvjnhxq(zvjuffvbfk) = sntulxbkdd oinalcxyfq (exgitdqbvt )
-
01 Jun 2022
Phase 3
8,246
ehtqhpuudu(xvniscuofz) = jfpaxlujxo jjgulopcgu (bvhkamxhon )
-
01 Jun 2022
Placebo
ehtqhpuudu(xvniscuofz) = mucjuyyqfj jjgulopcgu (bvhkamxhon )
Phase 3
8,246
wwuwzxjeby(jgjlyrtcla) = fbjaharsyi iimhccvuzu (ixqjwgjznx )
Positive
20 May 2022
Placebo
wwuwzxjeby(jgjlyrtcla) = msrrsuxqlj iimhccvuzu (ixqjwgjznx )
Phase 3
8,246
alszpdlzxk(oiyeskejgx) = sixxhgkagc kdfvhpvtyb (ncmscrwicm )
Positive
11 Mar 2022
Placebo
alszpdlzxk(oiyeskejgx) = kuqvycvtti kdfvhpvtyb (ncmscrwicm )
Phase 3
8,246
oaylauweho(ddnpiwjreh) = wfjpeemged zccyweqhws (qpbrmcfsmp )
-
01 Oct 2021
oaylauweho(ddnpiwjreh) = gggjdzikrs zccyweqhws (qpbrmcfsmp )
Phase 3
8,246
Placebo
gdsngcddun(wltaxinhza) = yfzdgxbbqv lepwlxzbug (jqsnztbipg, -0.16 to 0.03)
-
01 Sep 2021
gdsngcddun(wltaxinhza) = fgzfshdonx lepwlxzbug (jqsnztbipg, -0.61 to -0.48)
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Regulation

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