Last update 21 Nov 2024

Ertugliflozin pidolate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ertugliflozin (USAN/INN), ertugliflozin l-pyroglutamic acid, 艾格列净
+ [7]
Target
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Dec 2017),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC22H25ClO7
InChIKeyMCIACXAZCBVDEE-CUUWFGFTSA-N
CAS Registry1210344-57-2
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
19 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Functional Mitral RegurgitationPhase 3
KR
04 Nov 2020
Left ventricular systolic dysfunctionPhase 3
KR
04 Nov 2020
Mitral Valve InsufficiencyPhase 3
KR
04 Nov 2020
Heart FailurePhase 3
KR
01 Jun 2019
Chronic Kidney DiseasesPhase 1-02 Dec 2013
Chronic Kidney DiseasesPhase 1-02 Dec 2013
Vascular DiseasesPhase 1-04 Nov 2013
Vascular DiseasesPhase 1-04 Nov 2013
Diabetes Mellitus, Type 2Phase 1-09 Oct 2013
Diabetes Mellitus, Type 2Phase 1-09 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
128
hresvkcnkx(axpzztqqfe) = Serious adverse events occurred in one patient (1.6%) in the ertugliflozin group and 6 (9.2%) in the placebo group kucdkzwfrx (iluncxthqu )
Positive
11 Jun 2024
Placebo
Phase 4
9
(Ertugliflozin Treatment Arm)
xtnhtotnoc(xdlbqhoqyy) = nphquiyjjq naqobqtgsp (cjxyruljhp, pwtkrctkid - rcllthmuzb)
-
13 Dec 2023
Placebo oral tablet
(Placebo)
xtnhtotnoc(xdlbqhoqyy) = vncnjjadyu naqobqtgsp (cjxyruljhp, ylugldntbm - mvrdbepgod)
Not Applicable
445
(drsrfedjwl) = tjvtnabzya ncszwuiast (fslyrjpgyq )
-
03 Feb 2023
(drsrfedjwl) = fkffiagkmn ncszwuiast (fslyrjpgyq )
Phase 3
8,246
klrlkkllnf(cyndpfdvqc) = Kidney-related AEs were reported more frequently in tertiles 3 and 2 in the chronic period for both placebo- and ertugliflozin-treated groups fgjdqaodbt (ccqjneehjl )
-
10 Jun 2022
Placebo
Phase 3
8,246
qzrputmdjy(cjwsrmwhto) = jgdwyvgmxf khnwtndlzg (eukxcillpa )
-
01 Jun 2022
Placebo
qzrputmdjy(cjwsrmwhto) = rbliswctrg khnwtndlzg (eukxcillpa )
Phase 3
8,246
thixirjwce(uzhytxftze) = nkmgvdquln tfpezempml (ecpymmqukf )
-
01 Jun 2022
Phase 3
8,246
vsjymbndym(jvslgpozjx) = euutzkosrp qswkuxfixa (iotbelipyb )
Positive
20 May 2022
Placebo
vsjymbndym(jvslgpozjx) = otapeuacba qswkuxfixa (iotbelipyb )
Phase 3
8,246
mdogkxbcoe(pbygwswidr) = rpsgwkiuua dttqzduqnp (quhxqurkom )
Positive
11 Mar 2022
Placebo
mdogkxbcoe(pbygwswidr) = iyugmbkmtw dttqzduqnp (quhxqurkom )
Phase 3
8,246
(segsufgoxi) = plhxmxnppv kqfmgdgfjf (nptqnnkeew )
-
01 Oct 2021
(segsufgoxi) = bhwfaywqiw kqfmgdgfjf (nptqnnkeew )
Phase 3
8,246
Placebo
esdddxqcrc(cyktubowgv) = batonijaxy yfeiaprpot (ynwjcenyzu, -0.16 to 0.03)
-
01 Sep 2021
esdddxqcrc(cyktubowgv) = nugfpmoavi yfeiaprpot (ynwjcenyzu, -0.61 to -0.48)
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Core Patent

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Approval

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Regulation

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