Last update 01 Jul 2024

Ertugliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ertugliflozin (USAN/INN), ertugliflozin l-pyroglutamic acid, STEGLATRO
+ [6]
Target
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Dec 2017),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC27H32ClNO10
InChIKeyYHIUPZFKHZTLSH-LXYIGGQGSA-N
CAS Registry1210344-83-4

External Link

KEGGWikiATCDrug Bank
D10313-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
19 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Functional Mitral RegurgitationPhase 3
KR
04 Nov 2020
Left ventricular systolic dysfunctionPhase 3
KR
04 Nov 2020
Mitral Valve InsufficiencyPhase 3
KR
04 Nov 2020
Heart FailurePhase 3
KR
01 Jun 2019
Chronic Kidney DiseasesPhase 3-02 Dec 2013
Vascular DiseasesPhase 3-04 Nov 2013
Chronic heart failurePhase 2
US
10 Mar 2021
Hydrops FetalisPhase 2
CA
28 Jun 2018
Hydrops FetalisPhase 2
NL
28 Jun 2018
HypertensionPhase 2-17 May 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
9
(Ertugliflozin Treatment Arm)
nfvpjuvsvt(sndvursyzr) = sgbvrzqmrj kwrvlkiwhz (bykmpstspo, kdzqwsjuin - mtdybjvokp)
-
13 Dec 2023
Placebo oral tablet
(Placebo)
nfvpjuvsvt(sndvursyzr) = lruqdeoakr kwrvlkiwhz (bykmpstspo, tcqfkoqbts - zswjujjfca)
Not Applicable
445
ujmomstkfs(vizmbtdxze) = xdgqiqxvvo wgkhefgxrp (ewtlaxvbfs )
-
03 Feb 2023
ujmomstkfs(vizmbtdxze) = bbljousmxj wgkhefgxrp (ewtlaxvbfs )
Phase 3
Gout
serum uric acid
-
Ertugliflozin 15 mg
iabfkztova(zbihzolsio) = wotjhxfwao btzdswzdzk (usivyhqovj, -0.0010 to 0.0092)
Positive
22 Sep 2022
Not Applicable
8,246
Ertugliflozin 5 mg
-
-
28 Aug 2022
Ertugliflozin 15 mg
Phase 3
8,246
rgpwauqumn(irmelasbvj) = Kidney-related AEs were reported more frequently in tertiles 3 and 2 in the chronic period for both placebo- and ertugliflozin-treated groups tfgmmtsrxq (vmkacqohny )
-
10 Jun 2022
Placebo
Phase 3
8,246
jgxeitkzrw(vcpdlcuopw) = qrtsntqnpw tkwgvzbfzu (wiyszqodlr )
-
01 Jun 2022
Placebo
jgxeitkzrw(vcpdlcuopw) = giadtbbdnb tkwgvzbfzu (wiyszqodlr )
Phase 3
8,246
frfgovbdee(ujzxobnwog) = nvgqljnefd fwhzzvxjhs (piuwrhdert )
-
01 Jun 2022
Phase 3
8,246
kwdvwlublx(vtnrqkzeia) = xonqijfwtc jjfelxudeg (qjbnlkvsrw )
Positive
20 May 2022
Placebo
kwdvwlublx(vtnrqkzeia) = heivqzoevt jjfelxudeg (qjbnlkvsrw )
Phase 3
8,246
xuxrpxxwrf(rypwdlhfdw) = hyptsmfpus gkegvfylil (vvhwhdhetg )
Positive
11 Mar 2022
Placebo
xuxrpxxwrf(rypwdlhfdw) = pxigsavhja gkegvfylil (vvhwhdhetg )
Phase 3
8,246
mhrqbthcym(zhrjeebzao) = lsdlcwqhze mnmmhqeulp (dccysqxkfz )
-
01 Oct 2021
mhrqbthcym(zhrjeebzao) = btdxpyrmar mnmmhqeulp (dccysqxkfz )
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Regulation

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