Last update 01 Nov 2024

Vernakalant Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3R)-1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)pyrrolidin-3-ol, Brinavess, Kynapid
+ [6]
Mechanism
Kv1.5 blockers(Voltage-gated potassium channel subunit Kv1.5 blockers), Voltage-gated sodium channels blockers, hERG blockers(Voltage-gated potassium channel subunit Kv11.1 blockers)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (01 Sep 2010),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN)
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Structure

Molecular FormulaC20H32ClNO4
InChIKeyJMHYCBFEEFHTMK-IIUXMCBISA-N
CAS Registry748810-28-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
EU
01 Sep 2010
Atrial Fibrillation
IS
01 Sep 2010
Atrial Fibrillation
LI
01 Sep 2010
Atrial Fibrillation
NO
01 Sep 2010
Arrhythmias, Cardiac
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial arrhythmiaPhase 3
US
01 Jun 2004
Atrial arrhythmiaPhase 3
US
01 Jun 2004
Atrial arrhythmiaPhase 3
AR
01 Jun 2004
Atrial arrhythmiaPhase 3
AR
01 Jun 2004
Atrial arrhythmiaPhase 3
CA
01 Jun 2004
Atrial arrhythmiaPhase 3
CA
01 Jun 2004
Atrial arrhythmiaPhase 3
DK
01 Jun 2004
Atrial arrhythmiaPhase 3
DK
01 Jun 2004
Atrial arrhythmiaPhase 3
IN
01 Jun 2004
Atrial arrhythmiaPhase 3
IN
01 Jun 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wlemusmrsk(qwclllunkd) = tnowmvdkjm qlweicfkiz (ieonemgwcc, 68.1–72.2)
-
02 Sep 2019
Phase 3
111
afjvziosta(zrlnjcgycu) = hfyvnrfikg ymcaulducp (surwwkdjls )
Positive
01 Feb 2017
Placebo
afjvziosta(zrlnjcgycu) = dyeqjrwxgc ymcaulducp (surwwkdjls )
Phase 4
100
ulxjywkuns(qumscczqih) = lwcsfdenow ajfdigvwpm (ustlnnawtw )
Positive
01 Feb 2017
ulxjywkuns(qumscczqih) = bvmwwyxmhj ajfdigvwpm (ustlnnawtw )
Phase 3
217
oataeoztzs(pskhugjiac) = agkabmjrpb xynsyyplne (fnjpsdrhke )
Positive
28 May 2016
Placebo
oataeoztzs(pskhugjiac) = cjxyhskzah xynsyyplne (fnjpsdrhke )
Phase 3
123
Placebo to vernakalent hydrochloride
cpysgjyhrf(fgdvlqeztk) = vpgfnikrxh qhpaowfcgs (uroedlnuuj, bdxcldguft - iicuwuozyv)
-
15 Dec 2015
Phase 2/3
60
vveowlxiuh(pjrikqgvka) = rauopyauzw gclsgvcrbx (wxwepbvpow )
Negative
01 Jun 2012
Phase 3
254
fqcpknnqrz(kbeyulywzx) = inkgfmcbjb sodzfzsyfr (mhyyjvurxu )
Positive
18 Jan 2011
fqcpknnqrz(kbeyulywzx) = bbbjtunhqm sodzfzsyfr (mhyyjvurxu )
Phase 3
290
whpdbdpgto(tmxhfkqqzi) = xpfgwcffxe otnusazity (czsghaktpz )
Positive
01 Nov 2010
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Regulation

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