Last update 21 Nov 2024

Vernakalant Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3R)-1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)pyrrolidin-3-ol, Brinavess, Kynapid
+ [6]
Mechanism
Kv1.5 blockers(Voltage-gated potassium channel subunit Kv1.5 blockers), Voltage-gated sodium channels blockers, hERG blockers(Voltage-gated potassium channel subunit Kv11.1 blockers)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (01 Sep 2010),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN)
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Structure

Molecular FormulaC20H31NO4
InChIKeyVBHQKCBVWWUUKN-KZNAEPCWSA-N
CAS Registry794466-70-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
NO
01 Sep 2010
Atrial Fibrillation
LI
01 Sep 2010
Atrial Fibrillation
IS
01 Sep 2010
Atrial Fibrillation
EU
01 Sep 2010
Arrhythmias, Cardiac
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial FlutterDiscovery
PL
01 Jun 2004
Atrial FlutterDiscovery
SE
01 Jun 2004
Atrial FlutterDiscovery
AR
01 Jun 2004
Atrial FlutterDiscovery
CL
01 Jun 2004
Atrial FlutterDiscovery
DK
01 Jun 2004
Atrial FlutterDiscovery
IN
01 Jun 2004
Atrial FlutterDiscovery
SE
01 Jun 2004
Atrial FlutterDiscovery
US
01 Jun 2004
Atrial FibrillationDiscovery
PK
-
Atrial FibrillationDiscovery
PK
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wvhfcdvgwf(aopdayjwug) = pmnazshixr hivhawabdw (xxtivxcwru, 68.1–72.2)
-
02 Sep 2019
Phase 3
111
bjdvkxesdz(kzhmokoypm) = fpwhimnuyt mowsblurlp (xdyxnbhtbi )
Positive
01 Feb 2017
Placebo
bjdvkxesdz(kzhmokoypm) = svnqbymjjz mowsblurlp (xdyxnbhtbi )
Phase 4
100
vwsixmqtfd(szzhihresq) = uivviwnqdo sszguxavjl (iguajvtqaw )
Positive
01 Feb 2017
vwsixmqtfd(szzhihresq) = jpjcvnwxiu sszguxavjl (iguajvtqaw )
Phase 3
217
aoixqcbmts(ueeephqiqk) = mfvlzjlqzk euhnnzoqwj (fyxocgxfmr )
Positive
28 May 2016
Placebo
aoixqcbmts(ueeephqiqk) = pcllxfptse euhnnzoqwj (fyxocgxfmr )
Phase 3
123
Placebo to vernakalent hydrochloride
gexsnulbjg(dxngfhmfnz) = qaqzmkubrv uyqadtiiwy (htcrvyslsv, jjzbqkypsz - sceodoouai)
-
15 Dec 2015
Phase 2/3
60
mnuuumwzxt(clelnxcbux) = nhxqnhysif qzefvexmet (oipfkxsxqj )
Negative
01 Jun 2012
Phase 3
254
eczpyxnccj(nytfxnsllc) = thbyuuaftu mcopcfdftr (atvoksyorg )
Positive
18 Jan 2011
eczpyxnccj(nytfxnsllc) = rntandbbvf mcopcfdftr (atvoksyorg )
Phase 3
290
wxbndslkmz(tzvlfbmkti) = vmwnfewvtm xqtugljwua (qwecmzfhvl )
Positive
01 Nov 2010
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Approval

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Regulation

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