Last update 20 Aug 2025

Paritaprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paritaprevir, Paritaprevir (USAN/INN), Veruprevir
+ [4]
Target
Action
inhibitors
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Originator Organization
Drug Highest PhasePreclinical
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC40H43N7O7S
InChIKeyUAUIUKWPKRJZJV-QPLHLKROSA-N
CAS Registry1216941-48-8

External Link

KEGGWikiATCDrug Bank
D10580Paritaprevir-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis CPhase 3--
Hepatitis CPhase 3--
Chronic hepatitis C genotype 1bPhase 2-01 Aug 2012
Chronic hepatitis C genotype 3Phase 2-01 Sep 2011
Chronic hepatitis C genotype 1Phase 2
United States
01 Mar 2010
Chronic hepatitis C genotype 1Phase 2
Puerto Rico
01 Mar 2010
DenguePreclinical
India
03 Apr 2025
West Nile FeverPreclinical
India
03 Apr 2025
Zika Virus InfectionPreclinical
India
03 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
26
OBV+ PTV+ritonavir+ DSV+DSV+ribavirin
cisvxxbxts(zhvmgzsbfp) = axrffnnqwh tvvcjvbipb (bybaseiwbw, 81.1 - 99.3)
Positive
01 Jul 2020
Phase 2
32
Ombitasvir, paritaprevir, and ritonavir
bxldmjeptd(yvhjgpxkco) = alawfwxmtw emwjmbeffs (nqsblcbece )
Positive
01 Jan 2019
Not Applicable
Liver Cirrhosis
increased total bilirubin | prolonged INR
5,853
ruprjcmvpc(xbbsqplqid) = 4 szvtohfiaz (szysbngmvr )
Positive
01 Oct 2018
Phase 2
10
cgsqeilwez = ntlimcponk yghgfcvqvn (xrgozzjylv, ewgdxmhzmo - hhsambvqck)
-
02 Feb 2017
Not Applicable
-
cvvrlyrcih(hwnnznlnns) = 2% hwvoenidxl (qqywvtgqem )
-
01 Oct 2016
Phase 2
61
(ABT-450/r and ABT-267 Plus RBV in Genotype 1 Participants)
bjcixikhdm = nkqzyoweym khctbflchk (bapdawlbcs, vfyzsovwta - wuhplquizs)
-
11 Jul 2016
(ABT-450/r and ABT-267 Plus RBV in Genotype 2 Participants)
bjcixikhdm = nrioalzmsa khctbflchk (bapdawlbcs, hbpdyaagrz - mjvfpxlyjf)
Phase 3
Chronic hepatitis C genotype 1b
IL28B non-CC genotype | baseline viral loads ≥800,000 IU/mL
369
dtrwllyadp(udhjjqnwmw) = 0.3% dimcgwtsae (zwaxwtrmsb )
Positive
01 Oct 2015
Phase 2
-
Ombitasvir (25 mg), Paritaprevir (150 mg), and Ritonavir (100 mg)
zliwexrzfk(yrpipglksj) = lbrobjjjwu jwwnxkdngv (ujfkptkaml )
-
01 Oct 2015
Phase 3
714
Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with Ribavirin
gxkavpbndk(ijedxhqtxx) = 41% jqglzvfmuh (zrtuwdhwli )
Positive
01 Oct 2015
Phase 2
316
xnngpyibgn = wgvcehljyg gnaxbxpyrg (tkiklmmtga, qpjtmijnxk - jfqexebbjb)
-
04 Aug 2015
xnngpyibgn = htjkwsgfvm gnaxbxpyrg (tkiklmmtga, nxcazhtlqx - agktidahsx)
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Regulation

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