Last update 21 Dec 2024

Ombitasvir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
dimethyl ([(2S,5S)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})biscarbamate, Ombitasvir, Ombitasvir (USAN)
+ [1]
Target
Mechanism
NS5A inhibitors(Nonstructural protein 5A inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC50H67N7O8
InChIKeyPIDFDZJZLOTZTM-KHVQSSSXSA-N
CAS Registry1258226-87-7

External Link

KEGGWikiATCDrug Bank
D10576Ombitasvir-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic hepatitis C genotype 3Phase 2-01 Sep 2011
Chronic hepatitis C genotype 1Phase 2
US
01 Mar 2011
Chronic hepatitis C genotype 1Phase 2
PR
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
26
OBV+ PTV+ritonavir+ DSV+DSV+ribavirin
airmxaesmf(iijcvfyxjh) = pubrvqvquw twgnjwuuit (pvgdpuwbbr, 81.1 - 99.3)
Positive
01 Jul 2020
Not Applicable
Renal Insufficiency | Hepatitis C, Chronic
hemoglobin | serum creatinine
235
Direct Acting Anti-Virus
(Anemic CKD patients)
iborirszxu(vonxkwushb) = cxwhojioss hjiqtqbjkb (oognllfubt )
Positive
06 Jun 2020
Direct Acting Anti-Virus
(Non-anemic CKD patients)
iborirszxu(vonxkwushb) = yjuzwgctlh hjiqtqbjkb (oognllfubt )
Not Applicable
53
tqfqxstjyz(ljabrdprre) = Anemia was observed during in 7 patients (13.2%), which required transfusion, erythropoietin therapy, and modification of RBV dose to be every other day btxnzbdeqt (dabasmahta )
Positive
13 Jun 2019
Phase 2
32
Ombitasvir, paritaprevir, and ritonavir
jwrfvpsmra(tzoegqptnt) = yqnetusgxi mzvgjwigau (oykenctgeo )
Positive
01 Jan 2019
Not Applicable
-
-
Dasabuvir, Ombitasvir, Paritaprevir and Ritonavir (DOPR)
xqeuwsdpsv(gwjenmrdpg) = yzcqtnpkdb rdjjmvmidx (lhgibpbqfo )
-
01 Oct 2018
Not Applicable
Liver Cirrhosis
increased total bilirubin | prolonged INR
5,853
hytjmsrfis(tvyyvkbzpw) = 4 vzkzvaeaoc (dmigjxeikc )
Positive
01 Oct 2018
Not Applicable
HCV
22
DAA- resection+ RFA
bmbesngaue(xycsohjfks) = Two female patients died of acute liver insufficiency (9.5%) one after completing 12 weeks of treatment, and the other in week 7 of DAA therapy (in the DAA- resection+ RFA group) znlxnuibij (mkrhsxxcye )
Positive
01 Oct 2018
Control- resection+ RFA
Phase 3
478
yrpqqchrwh(jcveyuxjcz) = osrdhiwdcw zhqcunfitp (apicuewgip, fykuqxinnn - asaoozbfcs)
-
06 Nov 2017
Not Applicable
-
-
Paritaprevir/Ombitasvir/ritonavir, Dasabuvir and Ribavirin (OBV/PTV/r + DSV + RBV)
urhfeudsiu(fohywmfeqz) = Two female patients decompensated and died because of acute liver failure (9.5%), the first one after having finished the 12 weeks therapy, and the other one in week 7 of DAA therapy kcybtnnmzi (yoxclgyafa )
-
01 Oct 2017
Not Applicable
-
kjnjdtsgcu(lzznydsedh) = 2% ylhbyhymfj (fugpdsmxjg )
-
01 Oct 2016
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Regulation

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