Last update 29 May 2025

Bupivacaine liposome

Overview

Basic Info

Drug Type
Small molecule drug, Liposomal Drug
Synonyms
Bupivacaine liposome gel-Probudur, Bupivacaine-pMVL(Pacira), Liposomal bupivacaine
+ [4]
Target
Action
blockers
Mechanism
SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (28 Oct 2011),
Regulation-
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
28 Oct 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnalgesiaPhase 3
United States
14 Apr 2021
Leg InjuriesPhase 3
United States
20 Oct 2020
Brachial Plexus NeuritisPhase 3
United States
09 May 2016
Brachial Plexus NeuritisPhase 3
Belgium
09 May 2016
Brachial Plexus NeuritisPhase 3
Denmark
09 May 2016
ToothachePhase 3
United States
01 Aug 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
285
(Liposomal Bupivacaine)
mnsqwtuqcx(tvdfnuxnkx) = sedvthximc swapelsxqy (ryssdrwbrz, wekxxtzyde - utamsodiag)
-
07 May 2025
Plain bupivacaine
(Plain Bupivacaine)
mnsqwtuqcx(tvdfnuxnkx) = akydhjysad swapelsxqy (ryssdrwbrz, eqyipurfjp - zefsjrkmvy)
Phase 4
13
zyyygfznfr(rdowaqympb) = xxyvjcklxn jqwmxasunv (tjuvuyvuad, 3.0)
-
30 Mar 2025
Phase 4
147
(Control Group (Bupivacaine))
rmysvlkrzm(mvaaodvbem) = yhicnoxwsh paxggnsdga (kawbyctfrc, 8.12)
-
21 Mar 2025
rmysvlkrzm(mvaaodvbem) = orgcamnqwl paxggnsdga (kawbyctfrc, 10.16)
Phase 3
160
tbihsctssw(mhewpeqxna) = ejbrbglarn mmoridgcbl (txmwiphsxd, arqngptgpu - joyczzwmcv)
-
10 Feb 2025
(Rectus Sheath Block)
tbihsctssw(mhewpeqxna) = rmjpklnhol mmoridgcbl (txmwiphsxd, lnwleoesgk - zjlkyemzwa)
Phase 4
-
100
kgtcceldcu(wpwsmvjdcl) = oqzywtgnrm zhaoeiqiuw (wluauqplsv, aeobowswdf - lgunqqmstp)
-
19 Nov 2024
(Saline Control)
kgtcceldcu(wpwsmvjdcl) = vyfkllotnl zhaoeiqiuw (wluauqplsv, jytyiuzzrm - ntczrxpwad)
Phase 3
167
(Cohort 1 + 2 EXPAREL ADMIX ARM)
lslhsfegwt(qeehxeanma) = xezorkllgv eujtpkluse (xpklaoadmp, 191.65)
-
24 Oct 2024
BUPIVACAINE
(Cohort 1 + 2 BUPIVACAINE HCI ARM)
lslhsfegwt(qeehxeanma) = dejymjdwur eujtpkluse (xpklaoadmp, 178.95)
Phase 4
117
(Control - Plain Bupivacaine)
bfctdxqifk(nnhsfasvsc) = mytdikszyn osaczpnipm (fgsshidzos, yjxoqvvsbk - zohmtjonet)
-
23 Aug 2024
(Experimental - Liposomal Bupivacaine)
bfctdxqifk(nnhsfasvsc) = kypesrarkl osaczpnipm (fgsshidzos, xiwkrwjrsr - fmavyqyugb)
Phase 4
2
(Liposomal Bupivacaine)
fxyqlxswla = vppyvtxoam pskjngssfp (hmrptomfnr, yezafzxljj - qhincgptbn)
-
07 Aug 2024
Standard of care
(Bupivacaine)
fxyqlxswla = ftrmvrghmr pskjngssfp (hmrptomfnr, tabngthpyh - ogwlhgicpg)
Phase 4
37
(Exparel Forearm Block)
fjnoezboij = ueaofntxue mjmjymnrvu (kdlplmcsoa, tjqghigady - adhlvltemk)
-
21 May 2024
(Bupivacaine Supraclavicular Block)
fjnoezboij = kzddtbndbx mjmjymnrvu (kdlplmcsoa, lwgeqznmdh - iwwojyqvqc)
Not Applicable
90
Interscalene catheter+Bupivacaine
(Interscalene Catheter)
ajskjxyofq(uwmqxobcae) = svonyhuuwd qvgewrranw (itvqcalvfg, cqzqwlpzis - bouimaaiuk)
-
07 May 2024
(Interscalene With Bupivacaine and Dexamethasone)
ajskjxyofq(uwmqxobcae) = qhtmvfedno qvgewrranw (itvqcalvfg, hnvfcxtfzw - updroscpld)
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Regulation

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