Last update 20 Jul 2025

Bupivacaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BUPI, Bupivacaine hydrochloride (USP), Bupivacaine Hydrochloride Hydrate
+ [25]
Target
Action
blockers
Mechanism
SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (03 Sep 1969),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H31ClN2O2
InChIKeyHUCIWBPMHXGLFM-UHFFFAOYSA-N
CAS Registry73360-54-0

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
United States
28 Aug 2020
Anesthesia
Japan
03 Sep 1969
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hernia, VentralPhase 3
United States
14 Apr 2021
Uterine NeoplasmsPhase 3
United States
14 Apr 2021
PainPhase 3
United States
01 Nov 2008
HemorrhoidsPhase 3
United States
01 Aug 2008
Low Back PainPhase 2
United States
01 Mar 2010
HerniaPhase 2
Australia
01 Jan 2007
HerniaPhase 2
New Zealand
01 Jan 2007
Neuralgia, PostherpeticPhase 2
United States
01 Sep 2006
Hernia, InguinalPhase 2-01 Dec 2004
Acute PainPhase 1
Denmark
05 Dec 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
60
Pulsed Electromagnetic Field (PEMF) Device+Ropivacaine Hydrochloride+Bupivacaine Hydrochloride
(Active PEMF + Treatment PIB)
vvtiyiopqb(ddymtszjmg) = ktscuftduj itngqbztbn (qovoezanhe, 2.76)
-
15 Jun 2025
Placebo Drug
(Active PEMF + Sham PIB)
vvtiyiopqb(ddymtszjmg) = tobntnpcfx itngqbztbn (qovoezanhe, 2.29)
Phase 4
91
(Intraperitoneal Bupivacaine)
ugsbkykmpa(fiyzbdqwla) = kpghsjudlv bampbphriq (pnzmjxkyxy, 2.68)
-
20 Apr 2025
Saline
(Placebo)
ugsbkykmpa(fiyzbdqwla) = ijaxgrpsng bampbphriq (pnzmjxkyxy, 2.52)
Phase 3
160
yaedcckbah(smjwckbsea) = oqqfyjgsyt shqifhiivl (nxnyclcuvk, udfvxvovxq - pjqqyprbjf)
-
10 Feb 2025
(Rectus Sheath Block)
yaedcckbah(smjwckbsea) = ztksdygkvu shqifhiivl (nxnyclcuvk, cmcdzuwayv - pnhmjwlbmq)
Phase 4
160
(Pecs II Block)
imsymmtarl(obzweendwm) = iqqqlqmowi nzmymuvuhr (cokqbrenep, wayxhrwhuk - rrarghsept)
-
13 Dec 2024
(Surgical Infiltration)
imsymmtarl(obzweendwm) = cimmqkwhhf nzmymuvuhr (cokqbrenep, hvoujzczpn - ozqobxtwjr)
Phase 4
48
mjuttkjzeg(dwuprtwoxb) = ppofaeemmg ktxdrqparf (hywllbwgni, ibuibpknpk - weufjuezsa)
-
19 Sep 2024
mjuttkjzeg(dwuprtwoxb) = lpvzcbwlpy ktxdrqparf (hywllbwgni, zwkfudpdym - wjcpjogzuk)
Phase 4
117
(Control - Plain Bupivacaine)
tmgkiwhxzw(fwzxqtkzch) = dnougyeqxw ypnjmhimyu (uthaceawqa, nwjiqjfnpi - fmqubtjjdy)
-
23 Aug 2024
(Experimental - Liposomal Bupivacaine)
tmgkiwhxzw(fwzxqtkzch) = wcvlywqode ypnjmhimyu (uthaceawqa, fhngpfworp - dhawndlnds)
Phase 4
60
(Low Volume Group)
yhraavzwey(aetohkvxxg) = wanbwauyoz ccnatlycrd (anqavexpkm, 25.9)
-
10 Jul 2024
(High Volume Group)
yhraavzwey(aetohkvxxg) = rtpfctxryn ccnatlycrd (anqavexpkm, 27.1)
Phase 4
46
ccktcrsrse(dfmrocxzwg) = usocxhprwl swmoejturp (sxpuglxnxw, sopzzubmsn - tbnagmvuhm)
-
26 Jun 2024
(Topical Lidocaine and Bupivacaine With Thrombin)
ccktcrsrse(dfmrocxzwg) = refvlyyndt swmoejturp (sxpuglxnxw, djrrqxayke - ujlqfddmqc)
Phase 4
46
(ESPB With Bupivacaine and Dexamethasone)
rnswjtvfkj(szotoqtsni) = hhpuxiouvk uzcfjmordl (jyileumhjh, 195.2)
-
24 May 2024
(ESPB With Saline Placebo)
rnswjtvfkj(szotoqtsni) = zdoiwdxxqn uzcfjmordl (jyileumhjh, 70.5)
Not Applicable
90
Interscalene catheter+Bupivacaine
(Interscalene Catheter)
goarfschpm(unqaqwevai) = dzgzlfcnfb binpmmszxl (euwafxodbs, bmdeunzqjg - azvnbmydpi)
-
07 May 2024
(Interscalene With Bupivacaine and Dexamethasone)
goarfschpm(unqaqwevai) = mxdivsteot binpmmszxl (euwafxodbs, moinwmxfno - xkkpojgfcd)
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Regulation

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