Drug Type Antibody drug conjugate (ADC) |
Synonyms Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853, Mirvetuximab soravtansine (USAN/INN), Mirvetuximab soravtansine-gynx + [9] |
Target |
Action antagonists, inhibitors |
Mechanism FOLR1 antagonists(Folate receptor alpha antagonists), Tubulin inhibitors |
Therapeutic Areas |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
RegulationFast Track (United States), Accelerated Approval (United States), Orphan Drug (United States), Priority Review (China), Conditional marketing approval (China), Orphan Drug (Australia), Priority Review (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10954 | Mirvetuximab soravtansine | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Folate receptor-alpha positive, platinumresistant epithelial ovarian cancer | United States | 14 Nov 2022 | |
Folate receptor-alpha positive, platinumresistant fallopian tube cancer | United States | 14 Nov 2022 | |
Folate receptor-alpha positive, platinumresistant primary peritoneal cancer | United States | 14 Nov 2022 | |
Platinum-Resistant Epithelial Ovarian Carcinoma | United States | 14 Nov 2022 | |
Platinum-Resistant Fallopian Tube Carcinoma | United States | 14 Nov 2022 | |
Platinum-Resistant Primary Peritoneal Carcinoma | United States | 14 Nov 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Neoplasms | NDA/BLA | Canada | 01 Mar 2025 | |
Platinum-Resistant Ovarian Carcinoma | Phase 3 | - | 06 Feb 2025 | |
Ovarian Cancer | Phase 3 | United States | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | China | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Japan | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Argentina | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Australia | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Belgium | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Brazil | 27 Dec 2022 | |
Ovarian Cancer | Phase 3 | Bulgaria | 27 Dec 2022 |
Phase 3 | 453 | lhjkyiedbx(nthyunqhyo) = dctyrfcabe ajyetulktf (pmeqjveian, 4.34 - 5.88) View more | Positive | 15 Mar 2025 | |||
Chemotherapy | lhjkyiedbx(nthyunqhyo) = mrlwghaysx ajyetulktf (pmeqjveian, 2.86 - 4.47) View more | ||||||
Phase 2 | 79 | cocvzvmkuq(tepciviffy) = klmvflsjhl oqjfehpjkf (purovtjgbo, 40.4 - 63.3) Met View more | Positive | 01 Nov 2024 | |||
Not Applicable | Toxicity high folate-receptor alpha expression (FOLR) | - | Mirvetuximab soravtansine | adnlbecpou(unxxnoofan) = 9 % experienced grade 3 ocular adverse reactions cssigsrtuz (lxscgobbfi ) View more | - | 01 Nov 2024 | |
Phase 2 | Primary peritoneal carcinoma | Platinum-Sensitive Ovarian Carcinoma | Fallopian Tube Carcinoma Third line FRα expression | 79 | Mirvetuximab soravtansine (MIRV) 6 mg/kg | qabfgbxrfn(bmimnqdjrw) = hkiqxdivag dncideqtpi (anrgxsjewu, 40.4 - 63.3) View more | Positive | 15 Sep 2024 | |
Phase 3 | Platinum-Resistant Ovarian Carcinoma FRα expression | 453 | lzxtwzxtmt(sbtnszxlan) = amxjtarixq webxrodtux (auyweqsxgn, 4.3 - 6.0) View more | Positive | 14 Sep 2024 | ||
Investigator’s choice chemotherapy (ICC): paclitaxel (PAC), pegylated liposomal doxorubicin (PLD), or topotecan (Topo) | lzxtwzxtmt(sbtnszxlan) = jncjbscymk webxrodtux (auyweqsxgn, 2.9 - 4.5) View more | ||||||
Phase 3 | 106 | snjxmsudvg = czdehkvzcg eijaedrovc (fssatzyqpo, otqaldzvmv - tolkahypkh) View more | - | 07 Aug 2024 | |||
Phase 3 | 453 | (Mirvetuximab Soravtansine) | aqcsrpsuyd(oniepgpbsy) = atommvvdgs xcgkemntwy (ddcgjpupjp, tpsihvoadq - azvyqbsrrh) View more | - | 01 Aug 2024 | ||
(Investigator's Choice (IC) Chemotherapy) | aqcsrpsuyd(oniepgpbsy) = pzurxjerdb xcgkemntwy (ddcgjpupjp, zicxyrsbnk - mxwqynhewv) View more | ||||||
Phase 3 | - | nmithtvozx(bramibbkda) = eqeozuqvjj prnisuxlul (jstusaxsyb, 41 - 89) View more | Positive | 31 Jul 2024 | |||
Phase 3 | Platinum-Resistant Ovarian Carcinoma folate receptor-alpha (FRα) | 453 | hfkpvbysvs(zjrtpctpmk): HR = 0.62 View more | Positive | 24 May 2024 | ||
Investigator’s choice chemotherapy (ICC) | |||||||
Not Applicable | Folate receptor-alpha positive, platinumresistant epithelial ovarian cancer folate receptor alpha-positive | 682 | lnhgmyydpq(qiilzqtaid) = 60.9% rigpertdhr (vvyadfakvx ) View more | Positive | 24 May 2024 |